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69-year-old male presents with muscle aches

History of present illness: A 69-year-old patient presents for check-up and complains of aches in his limbs, like he has sore muscles from .....

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A Novel Variant in APOB Gene Causes Extremely Low LDL-C Without Known Adverse Effects

A Novel Variant in APOB Gene Causes Extremely Low LDL-C Without Known Adverse Effects

Source : https://casereports.onlinejacc.org/content/2/5/775

A novel frameshift variant was identified in APOB that segregates in a dominant manner with low levels of low-density lipoprotein cholesterol. Affected family members show no apparent clinical complications. There .....

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Measuring LDL-cholesterol: what is the best way to do it? : Current Opinion in Cardiology

Measuring LDL-cholesterol: what is the best way to do it? : Current Opinion in Cardiology

Source : https://journals.lww.com/co-cardiology/Abstract/9000/Measuring_LDL_cholesterol__what_is_the_best_way_to.98996.aspx

ion or measured with direct assays, these methods have limitations, particularly for patients with dyslipidaemias, low LDL-C, and hypertriglyceridemia. The focus of this review will be recent advances in the .....

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Association of LDL-C/HDL-C Ratio With Stroke Outcomes Within 1 Year After Onset: A Hospital-Based Follow-Up Study

Association of LDL-C/HDL-C Ratio With Stroke Outcomes Within 1 Year After Onset: A Hospital-Based Follow-Up Study

Source : https://www.frontiersin.org/articles/10.3389/fneur.2020.00408/full

Stroke remains a leading cause of death and disability. The low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C ratio) ratio has been confirmed to be a predictor of stroke. However, .....

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Progress in the seasonal variations of blood lipids: a mini-review

Progress in the seasonal variations of blood lipids: a mini-review

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01237-3

The seasonal variations of blood lipids have recently gained increasing interest in this field of lipid metabolism. Elucidating the seasonal patterns of blood lipids is particularly helpful for the prevention .....

A 32-year-old patient with type II diabetes came into the office complaining of some trouble breathing and staying energized throughout the day. Knowing that there is cardiovascular risk to patients .....

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Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3-5

Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3-5

Source : https://www.tandfonline.com/doi/full/10.1080/21623945.2020.1764799

ABSTRACT ABSTRACT Leptin potentially exerts atherogenic effects.This study evaluated the relationship between serum leptin levels and aortic stiffness in patients with stage 3-5 chronic kidney disease (CKD). Totally 205 participants .....

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Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients With Mixed Dyslipidemia: A Pilot Clinical Trial - PubMed

Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients With Mixed Dyslipidemia: A Pilot Clinical Trial - PubMed

Source : https://www.ncbi.nlm.nih.gov/pubmed/32397850

To evaluate the effect of berberine (BBR) plus bezafibrate administration on the lipid profile of patients with mixed dyslipidemia. A double-blind randomized pilot clinical trial with parallel groups was carried .....

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Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin

Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin

Source : https://heart.bmj.com/content/early/2020/05/12/heartjnl-2019-316165.long

Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ-mediated .....

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Association Between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels - PubMed

Association Between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels - PubMed

Source : https://www.ncbi.nlm.nih.gov/pubmed/32403373

in this cohort of postmenopausal women, VLDL-C was significantly associated to carotid IMT, independent of main cardiovascular risk factors. These findings pave the way for targeting circulating concentrations of VLDL-C .....

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The LDL-C/HDL-C ratio and 4-year risk of coronary artery disease: a retrospective study

Source : https://europepmc.org/article/ppr/ppr121976

Abstract BackgroundNumerous studies have demonstrated that the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio can reflect the positive correlation index LDL-C and the negative index HDL-C of coronary artery disease .....

Female Statin Patient With Muscle Cramping

A 62-year-old woman has a history of peripheral arterial disease and coronary artery disease had three stents placed over the past few years. .....

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Hyperlipidemia is a risk factor for bladder cancer in young adult men: a population-based cohort study

Source : https://europepmc.org/article/ppr/ppr152920

Hyperlipidemia is a risk factor for bladder cancer in young adult men: a population-based cohort study

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Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and impede hyperlipidemia

Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and impede hyperlipidemia

Source : https://onlinelibrary.wiley.com/doi/full/10.1002/ame2.12115

Md. Atiar Rahman Corresponding Author E-mail address: atiar@cu.ac.bd Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh Correspondence Md. Atiar Rahman, Department of Biochemistry and Molecular Biology, Faculty .....

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Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

Source : https://pubs.rsc.org/en/content/articlelanding/2020/ay/d0ay00305k/unauth

To better understand the mechanism of hyperlipidemia and discover potential biomarkers, we have used targeted metabolomics to analyze eight amino acid profiles of control and hyperlipidemia rats by a liquid .....

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Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk - American College of Cardiology

Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk - American College of Cardiology

Source : https://www.acc.org/latest-in-cardiology/clinical-trials/2017/03/16/00/46/fourier

The FOURIER trial showed that evolocumab was superior to placebo at reducing adverse cardiovascular events. The goal of the trial was to evaluate the efficacy and safety of evolocumab, a .....

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No Association Between Migraine Frequency and White Matter Lesions and Silent Brain Infarctions: A Study in a Series of Chronic Migraine Women - PubMed

No Association Between Migraine Frequency and White Matter Lesions and Silent Brain Infarctions: A Study in a Series of Chronic Migraine Women - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32343863/

As compared with the expected prevalence at this age, this study confirms that the prevalence of WML, in most cases small, deep and frontal, is increased in CM and EM. .....

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divAbstract

Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

Source : https://pubs.rsc.org/en/content/articlelanding/2020/ay/d0ay00305k/unauth

To better understand the mechanism of hyperlipidemia and discover potential biomarkers, we have used targeted metabolomics to analyze eight amino acid profiles of control and hyperlipidemia rats by a liquid .....

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The Effect of Probiotics Supplementation on Blood Pressure: A Systemic Review and Meta-Analysis - PubMed

The Effect of Probiotics Supplementation on Blood Pressure: A Systemic Review and Meta-Analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32334580/

doi: 10.1186/s12944-020-01259-x. 1 Department of Cardiology, Beijing Chao-Yang Hospital, No. 8 Gongti South Road, Chaoyang District, Beijing, 100043, China. 2 Children's Hospital, Capital Medical University, Beijing, China. 3 Department of .....

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VARIANTS OF HYPERLIPIDEMIA IN CHILDREN WITH INSULIN RESISTANCE

Source : https://inter.knmu.edu.ua/article/view/331

Obesity in adults and children is characterized by epidemiological prevalence with a tendency to increase. Purpose of the study- to analyze the lipid profile in overweight children, depending on the .....

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Effect of Milk Thistle on Hyperlipidemia: A Systematic Review

Effect of Milk Thistle on Hyperlipidemia: A Systematic Review

Source : https://eprints.mums.ac.ir/18707/

Sadeghi, Gholamreza and Mohammadzadeh, Fatemeh and Mazloum, Seyedreza (2020) Effect of Milk Thistle on Hyperlipidemia: A Systematic Review. Navid No, 22 (72). pp. 64-73. Introduction: Heart disease is the most .....

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Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis - PubMed

Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32312223/

1 From the TIMI (Thrombolysis in Myocardial Infarction) Study Group, Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (R.P.G., E.A.B., S.A.M., M.S.S.). 2 Oslo Universitetssykehus HF, Endocrinology-Morbid Obesity and Preventive .....

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Advanced Fibrosis of Non-Alcoholic Steatohepatitis Affects the Significance of Lipoprotein(a) as a Cardiovascular Risk Factor - PubMed

Advanced Fibrosis of Non-Alcoholic Steatohepatitis Affects the Significance of Lipoprotein(a) as a Cardiovascular Risk Factor - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32203743/

doi: 10.1016/j.atherosclerosis.2020.02.026. 1 Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan. 2 Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, .....

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Circulating Oxidized LDL Increased in Patients With Acute Myocardial Infarction Is Accompanied by Heavily Modified HDL - PubMed

Circulating Oxidized LDL Increased in Patients With Acute Myocardial Infarction Is Accompanied by Heavily Modified HDL - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32291330/

Oxidized low-density lipoprotein (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was .....

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Tomato seed oil attenuates hyperlipidemia and modulates gut microbiota in C57BL/6J mice

Tomato seed oil attenuates hyperlipidemia and modulates gut microbiota in C57BL/6J mice

Source : https://pubs.rsc.org/en/content/articlehtml/2020/fo/d0fo00133c

In this study we aimed to investigate the role of tomato seed oil (TSO) in the alleviation of hyperlipidemia and the regulation of gut microbiota in C57BL/6J mice.

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Two Phase 3 Trials of Inclisiran in Patients With Elevated LDL Cholesterol - PubMed

Two Phase 3 Trials of Inclisiran in Patients With Elevated LDL Cholesterol - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32187462/

Reductions in LDL cholesterol levels of approximately 50% were obtained with inclisiran, administered subcutaneously every 6 months. More injection-site adverse events occurred with inclisiran than with placebo. (Funded by the .....

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People with type 2 diabetes and heart disease may benefit from newer therapies

Source : https://www.sciencedaily.com/releases/2020/04/200413090751.htm

Coronary artery disease among people with type 2 diabetes may need to be treated more aggressively than in people with coronary artery disease who do not have diabetes. A new .....

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Migraine and Ischemic Stroke in Women. A Narrative Review - PubMed

Migraine and Ischemic Stroke in Women. A Narrative Review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32246455/

The commonality of factors associated with MWA and with MWA-associated stroke suggest that persons with secondary, ischemia-induced aura may be at elevated risk of stroke. Although further research is needed, .....

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The LDL-C/HDL-C ratio and 4-year risk of coronary artery disease: a retrospective study

Source : https://europepmc.org/article/ppr/ppr121976

BackgroundNumerous studies have demonstrated that the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio can reflect the positive correlation index LDL-C and the negative index HDL-C of coronary artery disease (CAD) .....

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Forty-Two-Year-Old Male With Family History of Coronary Heart Disease

A 42-year-old male whose father and both grandfathers all had a myocardial infarction in their late 40s presents to you .....

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The intake assessment of diverse dietary patterns on childhood hypertension: alleviating the blood pressure and lipidemic factors with low-sodium seafood rich in omega-3 fatty acids

The intake assessment of diverse dietary patterns on childhood hypertension: alleviating the blood pressure and lipidemic factors with low-sodium seafood rich in omega-3 fatty acids

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01245-3

Childhood hypertension (CH) is related to the dietary intake and diversity of children. The study aimed to assess the critical role of dietary diversity, and seafood long-chain n-3 polyunsaturated fatty .....

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The Effect of Synbiotics Supplementation on Anthropometric Indicators and Lipid Profiles in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial - PubMed

The Effect of Synbiotics Supplementation on Anthropometric Indicators and Lipid Profiles in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32248805/

doi: 10.1186/s12944-020-01244-4. 1 Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2 Research Development Center, Arash Women's .....

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Real-world data, theoretical application of guidelines, cost, and access: how do we optimize non-statin therapy for LDL-C/non-HDL-C/ApoB?

Real-world data, theoretical application of guidelines, cost, and access: how do we optimize non-statin therapy for LDL-C/non-HDL-C/ApoB?

Source : https://academic.oup.com/eurheartj/article-abstract/doi/10.1093/eurheartj/ehaa139/5817949?redirectedFrom=fulltext

You do not currently have access to this article. Subscription prices and ordering Real-world data, theoretical application of guidelines, cost, and access: how do we optimize non-statin therapy for LDL-C/non-HDL-C/ApoB? .....

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The beneficial effects of nutraceuticals and natural products on small dense LDL levels, LDL particle number and LDL particle size: a clinical review

The beneficial effects of nutraceuticals and natural products on small dense LDL levels, LDL particle number and LDL particle size: a clinical review

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01250-6

Cardiovascular diseases (CVDs) are globally the major causes of morbidity and mortality. Evidence shows that smaller and denser low-dense lipoprotein (sdLDL) particles are independent atherogenic risk factors for CVD due .....

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Effect of Arterial Hypertension and Hyperlipidemia on the Remodeling of Articular Cartilage and the Development of Osteoarthritis (Experimental Study)

Effect of Arterial Hypertension and Hyperlipidemia on the Remodeling of Articular Cartilage and the Development of Osteoarthritis (Experimental Study)

Source : https://link.springer.com/article/10.1134/S2079057020010087

Osteoarthritis (OA) is a degenerative inflammatory disease of the synovial joints associated with age, cardiovascular comorbidity, and other factors. It is based on articular cartilage (AC) and subchondral bone (SCB) .....

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Lipidomic profile and candidate biomarkers in septic patients

Lipidomic profile and candidate biomarkers in septic patients

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01246-2

Sepsis is a severe disease with a high mortality rate. Identification and treatment in the initial hours of the disease improve outcomes. Some biomarkers like procalcitonin and C-reactive protein are .....

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Change in Glucose Intolerance Status and Risk of Incident Cardiovascular Disease: Tehran Lipid and Glucose Study - PubMed

Change in Glucose Intolerance Status and Risk of Incident Cardiovascular Disease: Tehran Lipid and Glucose Study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32228577/

Among participants with IFG, IGT or IFG/IGT at baseline, only those who developed diabetes had a higher risk of developing CVD/CHD. Persistent IFG/IGT was not associated with higher risk, compared .....

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A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01236-4

Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases. Particularly in ischemic stroke (IS), the abnormal expression of MALAT1 played important roles including promotion of angiogenesis, inhibition of .....

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Neutrophil to High-Density Lipoprotein Ratio Has a Superior Prognostic Value in Elderly Patients With Acute Myocardial Infarction: A Comparison Study - PubMed

Neutrophil to High-Density Lipoprotein Ratio Has a Superior Prognostic Value in Elderly Patients With Acute Myocardial Infarction: A Comparison Study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32247314/

1 Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2 Second Clinical School, Tongji Hospital, Tongji Medical College, Huazhong University of Science .....

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Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome: Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of a Randomized Clinical Trial - PubMed

Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome: Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of a Randomized Clinical Trial - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32223446/

1 Division of Cardiology, University of Colorado School of Medicine, Aurora, CO. 2 Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, and INSERM-1148, Paris, France. 3 State University .....

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Why Patients With Familial Hypercholesterolemia Are at High Cardiovascular Risk? Beyond LDL-C Levels - PubMed

Why Patients With Familial Hypercholesterolemia Are at High Cardiovascular Risk? Beyond LDL-C Levels - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32205033/

Familial hypercholesterolemia (FH) is a common genetic cause of elevated low-density lipoprotein cholesterol (LDL-C) due to defective clearance of circulating LDL particles. All FH patients are at high risk for .....

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Glucose challenge metabolomics implicates the change of organic acid profiles in hyperlipidemic subjects

Glucose challenge metabolomics implicates the change of organic acid profiles in hyperlipidemic subjects

Source : https://onlinelibrary.wiley.com/doi/abs/10.1002/bmc.4815?af=R

Hyperlipidemia (HLP) is a major risk factor of diabetes and cardiovascular disease. Here, we applied gas chromatography-mass spectrometry to study differences in postprandial organic acid profiles in...

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Evaluating the Relationship Between Circulating Lipoprotein Lipids and Apolipoproteins With Risk of Coronary Heart Disease: A Multivariable Mendelian Randomisation Analysis - PubMed

Evaluating the Relationship Between Circulating Lipoprotein Lipids and Apolipoproteins With Risk of Coronary Heart Disease: A Multivariable Mendelian Randomisation Analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32203549/

1 Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom. 2 Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol, United Kingdom. .....

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The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis

The predictive study of the relation between elevated low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality in peritoneal dialysis

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01240-8

The low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio constitutes a strong risk predictor of cardiovascular events. However, the association between this ratio and cardiovascular death in peritoneal dialysis .....

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Effects of evolocumab therapy and low LDL‐C levels on vitamin E and steroid hormones in Chinese and global patients with type 2 diabetes

Effects of evolocumab therapy and low LDL‐C levels on vitamin E and steroid hormones in Chinese and global patients with type 2 diabetes

Source : https://onlinelibrary.wiley.com/doi/pdf/10.1002/edm2.123

In this prespecified analysis of the BERSON study in Chinese and global patients with type 2 diabetes and dyslipidaemia, we assessed the change from baseline in vitamin E, steroid hormones, .....