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Non-statin lipid-lowering therapy over time in very-high-risk patients: effectiveness of fixed-dose statin/ezetimibe compared to separate pill combination on LDL-C

Many patients at very-high atherosclerotic cardiovascular disease risk do not reach guideline-recommended targets for LDL-C. There is a lack of data on real-world use of non-statin lipid-lowering therapies (LLT) and ..... see more

Source : https://link.springer.com/article/10.1007/s00392-020-01740-8

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Novartis new analysis shows high consistency in lowering LDL-C in individual response with investigational inclisiran

EAST HANOVER, N.J., Aug. 30, 2020 /PRNewswire/ - Novartis today announced results from a post-hoc analysis of pooled data from the Phase III ORION-10 and -11 trials evaluating the individual ..... see more

Source : https://www.newsofthetrade.com/novartis-new-analysis-shows-high-consistency-in-lowering-ldl-c-in-individual-response-with-investigational-inclisiran/

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Polygenic Markers in Patients Diagnosed of Autosomal Dominant Hypercholesterolemia in Catalonia: Distribution of Weighted LDL-c-Raising SNP Scores and Refinement of Variant Selection - PubMed

Familial hypercholesterolemia (FH) is associated with mutations in the low-density lipoprotein (LDL) receptor ( LDLR ), apolipoprotein B ( APOB ), and proprotein convertase subtilisin/kexin 9 ( PCSK9 ) genes. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32942679/

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Effects of probiotic supplementation on cardiovascular risk factors in hypercholesterolemia: A systematic review and meta-analysis of randomized clinical trial - J. Funct. Foods - X-MOL

Effects of probiotic supplementation on cardiovascular risk factors in hypercholesterolemia: A systematic review and meta-analysis of randomized clinical trial Journal of Functional Foods ( IF 3.701 ) Pub Date : ..... see more

Source : https://www.x-mol.com/paper/1303160041971617792

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Weekly variation in markers of cardiometabolic health - the possible effect of weekend behavior - a cross-sectional study

Adolescents' health-related behavior varies from weekday to weekend. Only few studies, however, have examined to which degree such variation will affect markers of cardiometabolic health. Therefore, the primary aim of ..... see more

Source : https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01692-x

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The Role of Specific Components of a Plant-Based Diet in Management of Dyslipidemia and the Impact on Cardiovascular Risk - PubMed

Convincing evidence supports the intake of specific food components, food groups, or whole dietary patterns to positively influence dyslipidemia and to lower risk of cardiovascular diseases (CVD). Specific macro- and ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32883047/

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[Study on the relationship between sleep-related problems and dyslipidemia among adults in Beijing] - PubMed

Objective: To investigate the status quo of sleelated problems and relationship with dyslipidemia among adults in Beijing. Methods: From August to December 2017, 13 188 residents aged 18-79 years old ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32867431/

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Effects of disease activity on lipoprotein levels in patients with early arthritis: can oxidized LDL cholesterol explain the lipid paradox theory?

An increased risk of cardiovascular (CV) complications has been described in patients with rheumatoid arthritis (RA). It is the result of the combined effect of classic CV risk factors and ..... see more

Source : https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-02307-8

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Efficacy of Probiotics in Patients of Cardiovascular Disease Risk: a Systematic Review and Meta-analysis

This meta-analysis examined the effect of probiotics on outcomes associated with cardiovascular disease risk factors (high blood pressure, overweight BMI, high cholesterol and triglycerides, elevated HbA1c and serum glucose). All ..... see more

Source : https://link.springer.com/article/10.1007/s11906-020-01080-y

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Dietary treatment to lower cholesterol and triglyceride and ... : Current Opinion in Lipidology

mortality and age at death. In the PURE study, refined carbohydrate increased CVD risk whereas saturated fat did not despite increasing LDL-C levels; limitations are discussed. Reports on CVD risk ..... see more

Source : https://journals.lww.com/co-lipidology/Abstract/2020/08000/Dietary_treatment_to_lower_cholesterol_and.8.aspx

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High-intensity statin therapy yields better outcomes in acute coronary syndrome patients: a meta-analysis involving 26,497 patients

Whether high-intensity statin treatment provides more clinical benefits compared with standard statin regimens in acute coronary syndrome (ACS) patients remains controversial. This meta-analysis aimed to comparatively assess high-intensity and standard ..... see more

Source : https://link.springer.com/article/10.1186/s12944-020-01369-6

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Statin Prescription Rates, Adherence, and Associated Clinical Outcomes Among Women with PAD and ICVD

This study sought to investigate gender-based disparities in statin prescription rates and adherence among patients with peripheral arterial disease (PAD) and ischemic cerebrovascular disease (ICVD). We identified patients with PAD ..... see more

Source : https://link.springer.com/article/10.1007/s10557-020-07057-y

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A Novel Predictive Marker for In-Hospital Mortality in Acute Cerebral Infarction: Low-Density Lipoprotein Cholesterol to Lymphocyte Ratio - PubMed

Objectives Neutrophil to eosinophil ratio, neutrophil to lymphocyte ratio, C-reactive protein to albumin ratio, and red blood cell distribution width (RDW) have been studied in patients with acute cerebral infarction ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32855897/

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Hepatitis C eradication with direct acting antivirals leads to significant increase in serum cholesterol levels

Guidelines for the Care and Treatment of Persons Diagnosed with Chronic Hepatitis C Virus Infection. World Health Organization 2018 - Doyle MA, Galanakis C, Mulvihill E, et al. Hepatitis C ..... see more

Source : https://www.ghrnet.org/index.php/joghr/article/view/2920

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Plasma irisin levels are associated with hemodynamic and clinical outcome in idiopathic pulmonary arterial hypertension patients

Irisin has been considered to reflect oxidative stress. This study aimed to show whether plasma irisin levels are correlated with hemodynamic dysfunction and predict the clinical outcome of patients with ..... see more

Source : https://link.springer.com/article/10.1007/s11739-020-02467-0

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High-intensity statin therapy yields better outcomes in acute coronary syndrome patients: a meta-analysis involving 26,497 patients

Whether high-intensity statin treatment provides more clinical benefits compared with standard statin regimens in acute coronary syndrome (ACS) patients remains controversial. This meta-analysis aimed to comparatively assess high-intensity and standard ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01369-6

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Prognostic impact of estimated remnant-like particle cholesterol in patients with differing glycometabolic status: an observational cohort study from China

It is uncertain whether estimated remnant-like particle cholesterol (RLP-C) could predict residual risk in patients with different glycometabolic status. This study aimed to evaluate the relationship between estimated RLP-C and ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01355-y

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Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile in T1DM individuals, and analysed differences with ..... see more

Source : https://link.springer.com/article/10.1186/s12933-020-01099-0

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Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome

Background: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290587/

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Glycoxidation of LDL Generates Cytotoxic Adducts and Elicits Humoral Response in Type 2 Diabetes Mellitus

Abstract. This study elucidates the immunological implications of methylglyoxal (MGO) modified LDL in diabetes type 2 patients (T2DM). Under in-vitro modificat see more

Source : https://academic.oup.com/glycob/advance-article-abstract/doi/10.1093/glycob/cwaa077/5889978

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Small interfering RNA to proprotein convertase... : Current Opinion in Lipidology

ll interfering RNA developed for this purpose is inclisiran. Here, we review its clinical trial data and potential impact on patient management. Recent findings Inclisiran achieves sustained, additional 50% LDL-C ..... see more

Source : https://journals.lww.com/co-lipidology/Abstract/2020/08000/Small_interfering_RNA_to_proprotein_convertase.4.aspx?context=FeaturedArticles&collectionId=4

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Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level: A Critical Discussion

Atherosclerotic cardiovascular diseases (ASCVDs) cause every fifth death worldwide. However, it is possible to prevent the progression of ASCVDs by reducing circulating concentrations of low-density lipoprotein cholesterol (LDL-C). Recent large ..... see more

Source : https://www.mdpi.com/2072-6643/12/8/2346

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Low-Density Lipoprotein Cholesterol Targets in Patients With Coronary Heart Disease in Extremadura (Spain): LYNX Registry | Gomez-Barrado | Cardiology Research

Background: Low-density lipoprotein cholesterol (LDL-C) contributes decisively to the development of cardiovascular disease (CVD). In the LYNX registry we determined the rate of achievement of the target value of LDL-C, ..... see more

Source : https://www.cardiologyres.org/index.php/Cardiologyres/article/view/1079/1117

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A novel and dominant factor that mediates oxidative stress-induced apoptotic signaling - autocrine/paracrine mechanism of the secreted form of eukaryotic translation initiation factor 5A

Jing Yu Oxidative stress plays a critical role in the pathogenesis of various disorders including cardiovascular diseases, such as ischemia/reperfusion (I/R) injury, atherosclerosis, dyslipidemia, chronic kidney disease (CKD), arrhythmia, and ..... see more

Source : https://vpjournal.net/article/view/3570

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Microarray analysis of long non-coding RNA expression profiles in low high-density lipoprotein cholesterol disease

Low high-density lipoprotein cholesterol (HDL-C) disease with unknown etiology has a high prevalence in the Xinjiang Kazak population. In this study, long noncoding RNAs (lncRNAs) that might play a role ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01348-x

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Prevalence and Predictors of Out-of-Target LDL Cholesterol 1 to 3 Years After Myocardial Infarction. A Subanalysis From the EYESHOT Post-MI Registry - J. Cardiovasc. Pharmacol. Ther. - X-MOL

Journal of Cardiovascular Pharmacology and Therapeutics--Prevalence and Predictors of Out-of-Target LDL Cholesterol 1 to 3 Years After Myocardial Infarction. A Subanalysis From the EYESHOT Post-MI Registry,Angelo Silverio; Rossella Maria Benvenga; ..... see more

Source : https://www.x-mol.com/paper/1291497429511315456

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Association between Low-Density Lipoprotein Cholesterol Levels and Proximal Single Subcortical Infarction in Comparison with Distal Single Subcortical Infarction - J. Stroke Cerebrovasc. Dis. - X-MOL

Single subcortical infarction (SSI) in the middle cerebral artery (MCA) territory can be classified into proximal SSI (pSSI) and distal SSI (dSSI) based on the heterogeneous pathogenesis. It is hypothesized ..... see more

Source : https://www.x-mol.com/paper/1290715047799693312?adv

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Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein

The biological pathways through which vitamin D is involved in the regulation of systemic inflammation remain largely unknown. The objective of this study was to evaluate the role of vitamin ..... see more

Source : https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00455-x

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Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality

The aim of this study was to investigate the effects of 6-months consumption of green-banana biomass on the LDL particle functionality in subjects with type 2 diabetes. Subjects (n = 39, mean ..... see more

Source : https://www.nature.com/articles/s41598-020-69288-1

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Proprotein Convertase Subtilisin/Kexin-Type 9 and Lipid Metabolism

Shoudong Guo Xiao-dan Xia Hong-mei Gu Da-wei Zhang Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1276) Plasma levels of cholesterol, especially low-density lipoprotein cholesterol ..... see more

Source : https://link.springer.com/chapter/10.1007/978-981-15-6082-8_9

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Association between carotid intima media thickness and small dense low-density lipoprotein cholesterol in acute ischaemic stroke

Intima-media thickness (IMT) and small dense low-density lipoprotein cholesterol (sdLDL-C) have been reported to be related to atherosclerosis and stroke. This study is trying to explore the association between IMT ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01353-0

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Correlations between Iron Metabolism Parameters, Inflammatory Markers and Lipid Profile Indicators in Patients with Type 1 and Type 2 Diabetes Mellitus

This study aims to establish relationships between inflammatory status, ferrokinetics and lipid metabolism in patients with diabetes mellitus. Subclinical inflammation was assessed by levels of high-sensitive C-reactive protein, tumor necrosis ..... see more

Source : https://www.mdpi.com/2075-4426/10/3/70

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Beneficial Effects of Apple Vinegar on Hyperglycemia and Hyperlipidemia in Hypercaloric-Fed Rats

The main objective of this study is to determine the effects of apple vinegar on the metabolic changes caused by hypercaloric diet in Wistar rats. Apple vinegar was first analyzed ..... see more

Source : https://www.hindawi.com/journals/jdr/2020/9284987/

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Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway

The effect and potential molecular mechanisms of berberine on gluconeogenesis in skeletal muscles and adipose tissues were investigated. After adaptive feeding for one week, 8 rats were randomly selected as ..... see more

Source : https://link.springer.com/article/10.1007/s11596-020-2210-4

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Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Cholesterol: A new game player accelerating vasculopathy caused by SARS-CoV-2?

Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions The pandemic of coronavirus disease (COVID-19) has become a global threat to public health. Functional impairments in multiple organs have been ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347957/

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Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: the LipoLab Study

Atherosclerosis is the underlying process in cardiovascular disease (CVD), the first cause of death in developed countries. We aimed to identify people with no known CVD and normal values of ..... see more

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/ijcp.13610

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Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis

Arrigo F. G. Cicero, Federica Fogacci, Adrian V. Hernandez, Maciej Banach, on behalf of the Lipid and Blood Pressure Meta-Analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP) ..... see more

Source : https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003121

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Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein

The biological pathways through which vitamin D is involved in the regulation of systemic inflammation remain largely unknown. The objective of this study was to evaluate the role of vitamin ..... see more

Source : https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00455-x

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Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein

The biological pathways through which vitamin D is involved in the regulation of systemic inflammation remain largely unknown. The objective of this study was to evaluate the role of vitamin ..... see more

Source : https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-020-00455-x

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"Apple does not fall far from the tree" - subclinical atherosclerosis in children with familial hypercholesterolemia

Familial hypercholesterolemia (FH) increases the risk of atherosclerosis in children and adults. Atherosclerotic cardiovascular disease in young patients FH is usually subclinical but recognition of children with more pronounced changes ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01335-2

Sixty-One-Year-Old Male with Family History of Myocardial Disease

A 61-year-old male desired a thorough exam and preventative treatment given his familial history. When he was 50, the patient's father ..... see more

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Aging | The impact of the cumulative burden of LDL-c and hs-CRP on cardiovascular risk: a prospective, population-based study - Full Text

Full Text - Background: This study aims to demonstrate the impact of the cumulative burden of low density lipoprotein-cholesterol (cumLDL-c) and high sensitivity C-reactive protein (cumhs-CRP) on cardiovascular risk.Results: During ..... see more

Source : https://www.aging-us.com/article/103365/text

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LDL-cholesterol to HDL-cholesterol ratio discordance with lipid parameters and carotid intima-media thickness: a cohort study in China - PubMed

A high LDL-C/HDL-C ratio could significantly increase elevated CIMT risk regardless of discordance/concordance with TC, TGs, LDL-C and HDL-C Even a low LDL-C/HDL-C ratio with discordantly high LDL-C and normal ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32552893/

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(PDF) The Alcohol-High-Density Lipoprotein Athero-Protective Axis

Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate alcohol consumption is associated with reduced atherosclerotic cardiovascular disease ..... see more

Source : https://www.researchgate.net/publication/342634841_The_Alcohol-High-Density_Lipoprotein_Athero-Protective_Axis