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Curbside Consult: 56-year-old patient on high dosage of metformin

A 56-year-old African-American woman came to the clinic. She has had type II diabetes since she turned 40 .....

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Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8

Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....

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Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8

Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....

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Statins may lower mortality in high-risk prostate cancer patients

Statins may lower mortality in high-risk prostate cancer patients

Source : https://www.eurekalert.org/pub_releases/2020-02/tju-sml021020.php

PHILADELPHIA - Among high-risk prostate cancer patients - those with high PSA and Gleason scores of 8 or more - many will develop a difficult-to-treat disease. Preliminary research suggests that .....

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Association Between Obstructive Sleep Apnea and Lipid Metabolism During REM and NREM Sleep - PubMed

Association Between Obstructive Sleep Apnea and Lipid Metabolism During REM and NREM Sleep - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32003732-association-between-obstructive-sleep-apnea-and-lipid-metabolism-during-rem-and-nrem-sleep/

1 Department of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China. 2 Otolaryngological Institute .....

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Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8

Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....

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Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes

Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744677/

The role of apolipoprotein E gene (APOE) in lipid metabolism has been well established, and APOE is associated with the risk of cardiovascular disease (CVD) and diabetes mellitus (DM). However, .....

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Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1710063

(2020). Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6. OncoImmunology: Vol. 9, No. 1, 1710063.

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A 32-year-old female, Amber, is a non-smoker with a history of familial hypercholesterolemia (FH). Her father underwent a coronary artery bypass grafting (CABG) at the age of 38 and has .....

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The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

Source : https://www.mdpi.com/1420-3049/25/2/271/htm

Curcumin is the main secondary metabolite of Curcuma longa and other Curcuma spp, and has been reported to have some potential in preventing and treating some physiological disorders. This study .....

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HDL-cholesterol and breast cancer risk

HDL-cholesterol and breast cancer risk

Source : http://news.vumc.org/2020/01/23/hdl-breast-cancer-risk/

Circulating lipids have been proposed to influence the risk of breast, colorectal and other common cancers, but results from conventional epidemiologic studies have been inconsistent. Alicia Beeghly-Fadiel, PhD, Nikhil Khankari, .....

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Improving cardiovascular health of the most vulnerable

Improving cardiovascular health of the most vulnerable

Source : https://medicalxpress.com/news/2020-01-cardiovascular-health-vulnerable.html

Starting in 2016, a two-year partnership between the North Carolina Chapter of the American College of Cardiology (NCACC) and the North Carolina Association of Free and Charitable Clinics (NCAFCC) provided .....

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A patient, 60 and male, came into the clinic today. We did an annual exam, looking at cholesterol and other factors. The patient's LDL levels were high, and HDL levels .....

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Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD

Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD

Source : https://cjasn.asnjournals.org/content/15/1/47

Background and objectives Triglyceride-rich lipoproteins may contribute to the high cardiovascular risk of patients with CKD. This study evaluated associations of apo-B and markers of triglyceride-rich lipoproteins with cardiovascular events .....

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The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

Source : https://www.mdpi.com/1420-3049/25/2/271/htm

Curcumin is the main secondary metabolite of Curcuma longa and other Curcuma spp, and has been reported to have some potential in preventing and treating some physiological disorders. This study .....

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Hyperlipidemia affects tight junctions and pump function in the corneal endothelium.

Hyperlipidemia affects tight junctions and pump function in the corneal endothelium.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31945314

Am J Pathol. 2020 Jan 13. pii: S0002-9440(20)30006-7. doi: 10.1016/j.ajpath.2019.11.008. [Epub ahead of print]

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Effects of intensive lipid-lowering therapy on mortality after coronary bypass surgery: A meta-analysis of 7 randomised trials.

Effects of intensive lipid-lowering therapy on mortality after coronary bypass surgery: A meta-analysis of 7 randomised trials.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31865057

BACKGROUND AND AIMS: The recent reported analysis from the ODYSSEY OUTCOMES trial showed that patients with previous coronary bypass graft surgery (CABG) had enhanced clinical benefits in response to intensive .....

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Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis

Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/coa.13421

To define the impact of hyperlipidemia as a coexisting factor on the prognosis of Idiopathic Sudden Sensorineural Hearing Loss (ISSHL), we prospectively analysed the Lipid‐lowering therapy Group (LLTG) data compared .....

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Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene

Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1183-4

Use of ezetimibe on top of statin therapy has been shown to be effective to reduce LDL cholesterol level in hypercholesterolemic patients. However, little is known regarding the individual variety .....

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Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders

Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1173-6

Adipogenesis is the process of adipocytes formation from unspecialized progenitor cells called mesenchymal stromal cells. Numerous mechanisms including epigenetic regulation modulate the correct progress of this process.

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Potentially modifiable blood triglyceride levels by the control of conventional risk factors

Potentially modifiable blood triglyceride levels by the control of conventional risk factors

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911291/

Triglyceride (TG) is known to be regulated by multiple lifestyle factors rather than genetic factors. This cross-sectional and community-based study (Healthy Twin study in Korea) aimed to estimate the "modifiable .....

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A 32-year-old patient with type II diabetes came into the office complaining of some trouble breathing and staying energized throughout the day. Knowing that there is cardiovascular risk to patients .....

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Alirocumab therapy in individuals with type 2 diabetes mellitus and atherosclerotic cardiovascular disease: analysis of the ODYSSEY DM-DYSLIPIDEMIA and DM-INSULIN studies

Alirocumab therapy in individuals with type 2 diabetes mellitus and atherosclerotic cardiovascular disease: analysis of the ODYSSEY DM-DYSLIPIDEMIA and DM-INSULIN studies

Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-019-0951-9

Individuals with diabetes often have high levels of atherogenic lipoproteins and cholesterol reflected by elevated low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (ApoB), and LDL particle number .....

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Efficacy of combination therapy with ezetimibe and statins versus a double dose of statin monotherapy in participants with hypercholesterolemia: a meta-analysis of literature

Efficacy of combination therapy with ezetimibe and statins versus a double dose of statin monotherapy in participants with hypercholesterolemia: a meta-analysis of literature

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1182-5

The aim of this study was to compare and summarize the lipid-altering effects of combination therapy with ezetimibe and statins (E/S) and a double dose of statin (D/S) monotherapy on .....

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Interaction between adipocytes and high-density lipoprotein:new insights into the mechanism of obesity-induced dyslipidemia and atherosclerosis

Interaction between adipocytes and high-density lipoprotein:new insights into the mechanism of obesity-induced dyslipidemia and atherosclerosis

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1170-9

Obesity is the most common nutritional disorder worldwide and is associated with dyslipidemia and atherosclerotic cardiovascular disease. The hallmark of dyslipidemia in obesity is low high density lipoprotein (HDL) cholesterol .....

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Integrative genomic analysis identified common regulatory networks underlying the correlation between coronary artery disease and plasma lipid levels

Integrative genomic analysis identified common regulatory networks underlying the correlation between coronary artery disease and plasma lipid levels

Source : https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-01271-9

Coronary artery disease (CAD) and plasma lipid levels are highly correlated, indicating the presence of common pathways between them. Nevertheless, the molecular pathways underlying the pathogenic comorbidities for both traits .....

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Screening of Hyperlipidemia Among Patients With Rheumatoid Arthritis in the United States

Screening of Hyperlipidemia Among Patients With Rheumatoid Arthritis in the United States

Source : https://onlinelibrary.wiley.com/doi/epdf/10.1002/acr.23810?referrer_access_token=ac2NBA0P_RQXGtgd7qnT6U4keas67K9QMdWULTWMo8MQbCY0mXvabwzS-uT_RTmlAw14GmYqNV-SOfspUho9uObfD5mtAcZB4kJpeesuwg2Wd2zDiB8vJnbgcxq_mAXncjzua2LI8OSMo8PodPQ0HA==

Dr. Navarro‐Millán's work was supported by the NIH (grant K23‐AR‐068449 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases). Dr. Fraenkel's work was supported by the NIH (award .....

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A young, male patient, only 20, came into the clinic for a yearly general exam but complained of being more tired than usual lately. After performing a physical exam, taking .....

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Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis

Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1175-4

Endothelial lipase (EL) plays an important role in lipoprotein metabolism and atherosclerosis. To study the functional roles of EL, we recently generated transgenic (Tg) rabbits and reported that increased hepatic .....

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Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial

Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial

Source : https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-019-1132-8

Alternate-day fasting (ADF) is a novel diet therapy that may achieve reduction in body weight and improvement of dyslipidaemia, but the impact of this diet on patients with non-alcoholic fatty .....

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Self‐Albumin Camouflage of Carrier Protein Prevents Nontarget Antibody Production for Enhanced LDL‐C Immunotherapy

Self‐Albumin Camouflage of Carrier Protein Prevents Nontarget Antibody Production for Enhanced LDL‐C Immunotherapy

Source : https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201901203

Elevated low‐density lipoprotein cholesterol (LDL‐C) increases the risk of atherosclerotic cardiovascular disease. Peptide‐based PCSK9 vaccines have shown a promising prospect of reducing LDL‐C. In peptide vaccine (pVax) design, the peptide .....

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Impact of the Martin/Hopkins modified equation for estimating LDL-C on lipid target attainment in a high risk patient population.

Impact of the Martin/Hopkins modified equation for estimating LDL-C on lipid target attainment in a high risk patient population.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31843663

Clin Biochem. 2019 Dec 13. pii: S0009-9120(19)31076-8. doi: 10.1016/j.clinbiochem.2019.12.002. [Epub ahead of print]

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Leptin, resistin and visfatin as useful predictors of gestational diabetes mellitus

Leptin, resistin and visfatin as useful predictors of gestational diabetes mellitus

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1169-2

Lipids and adipokines including leptin, resistin and visfatin play various roles in the pathophysiology of Gestational Diabetes Mellitus (GDM). This study was aimed at determining whether serum leptin, resistin and .....

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First long-term estimates suggest link between cholesterol levels and risk of heart disease and stroke

Source : https://www.sciencedaily.com/releases/2019/12/191205130556.htm

The observational and modelling study which used individual-level data from almost 400,000 people extends existing research because it suggests that increasing levels of non-HDL cholesterol may predict long-term cardiovascular risk .....

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Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease

Emerging evidences for the opposite role of apolipoprotein C3 and apolipoprotein A5 in lipid metabolism and coronary artery disease

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1166-5

Apolipoprotein C3 (apoC3) and apolipoprotein A5 (apoA5), encoded by APOA1/C3/A4/A5 gene cluster, are two critical regulators of plasma triglyceride (TG) metabolism. Deficiency of apoC3 or apoA5 led to significant decreased .....

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Self‐Albumin Camouflage of Carrier Protein Prevents Nontarget Antibody Production for Enhanced LDL‐C Immunotherapy

Self‐Albumin Camouflage of Carrier Protein Prevents Nontarget Antibody Production for Enhanced LDL‐C Immunotherapy

Source : https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201901203

Elevated low‐density lipoprotein cholesterol (LDL‐C) increases the risk of atherosclerotic cardiovascular disease. Peptide‐based PCSK9 vaccines have shown a promising prospect of reducing LDL‐C. In peptide vaccine (pVax) design, the peptide .....

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HDL-C to hsCRP ratio is associated with left ventricular diastolic function in absence of significant coronary atherosclerosis

HDL-C to hsCRP ratio is associated with left ventricular diastolic function in absence of significant coronary atherosclerosis

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1157-6

High-density lipoprotein cholesterol (HDL-C) is considered as a protective marker of coronary atherosclerotic disease (CAD). It is still not clear if HDL-C is associated with left ventricular (LV) diastolic function .....

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Early cholesterol treatment lowers heart disease risk: study

Early cholesterol treatment lowers heart disease risk: study

Source : https://medicalxpress.com/news/2019-12-early-cholesterol-treatment-lowers-heart.html

Treating younger people with high cholesterol levels may help reduce their risk of heart attack or stroke in later life, a major study showed Wednesday. Described as the "most comprehensive" .....