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Personalized medicine in lipid-modifying therapy

The choice of lipid-modifying treatment is largely based on the absolute level of cardiovascular risk and baseline lipid profile. Statins are the first-line treatment for most patients requiring reduction of ..... see more

Source : https://doi.org/10.2217/pme-2020-0110

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Association of small dense LDL-cholesterol with disease severity, hypertension status and clinical outcome in patients with coronary artery disease - PubMed

1 State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. 2 Department of Cardiology, Xuanwu ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33186323/

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Novel Experimental Agents for the Treatment of Hypercholesterolemia | JEP

Ivan Pećin, 1, 2 Željko Reiner 1, 2 1Zagreb School of Medicine, University of Zagreb, Zagreb, Croatia; 2Division of Metabolic Diseases, Department of Internal Medicine, University Hospital Center, Zagreb, Croatia ..... see more

Source : https://doi.org/10.2147/JEP.S267376

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Sixty-One-Year-Old Male with Family History of Myocardial Disease

A 61-year-old male desired a thorough exam and preventative treatment given his familial history. When he was 50, the patient's father ..... see more

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  • from Doctor Unite 1 day 18 hours
    Would switch his simvastatin to rosuvastatin 40 mg daily with a goal LDL less than 70 and LDL-P less than 1000. Add zetia or PCSK9I if not at goal. Show More
  • from Doctor Unite 1 day 18 hours
    Would switch his simvastatin to rosuvastatin 40 mg daily with a goal LDL less than 70 and LDL-P less than 1000. Add zetia or PCSK9I if not at goal. Show More
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Lipid Level, Lipid Variability, and Risk of Multiple Myeloma: A Nationwide Population-Based Study of 3,527,776 Subjects - PubMed

(1) Background: There is evidence that abnormality in lipid metabolism promotes cancer development. This study investigated whether lipid level and its variability are associated with the development of MM at ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33572660/

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Usefulness of Novel Martin/Hopkins and Sampson Equations over Friedewald Equation in Cardiology Outpatients: A CVSCORE-TR Substudy.

Background and aims The Friedewald equation (LDL-Cf) is known to produce inaccurate estimations of low-density lipoprotein cholesterol (LDL-C) when triglycerides are high (>400 mg/dL) or LDL-C is low ( see more

Source : https://europepmc.org/article/med/33570835

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Improving Statin Adherence in Patients at Risk for Cardiovascular Disease

US Pharm. 2021;46(2):6-12. ABSTRACT: Lipid-lowering medications have been shown to be efficacious, but adherence can be challenging in patients who are at risk for cardiovascular disease. It is critical for ..... see more

Source : https://www.uspharmacist.com/article/improving-statin-adherence-in-patients-at-risk-for-cardiovascular-disease/preview/uspeditorial?utm_source=TrendMD&utm_medium=cpc&utm_campaign=US_Pharmacist_TrendMD_0

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67 year-old Hispanic female

Mrs. Sanders is a 67 year-old Hispanic female who is coming in for her yearly checkup. She is prediabetic, a non-smoker, drinks occasionally (for ..... see more

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The Effects of SGLT2 Inhibitors on Lipid Metabolism - PubMed

Sodium glucose co-transporter 2 (SGLT2) inhibitors are effective antihyperglycemic agents by inhibiting glucose reabsorption in the proximal tubule of the kidney. Besides improving glycemic control in patients with type 2 ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33535652/

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Ovarian cancer risk in relation to blood lipid levels and hyperlipidemia: a systematic review and meta-analysis of observational epidemiologic studies - PubMed

1 Department of Oncology, Georgetown University School of Medicine, Washington, DC. 2 Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32483012/

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Empagliflozin increases plasma levels of campesterol, a marker of cholesterol absorption, in patients with type 2 diabetes: Association with a slight increase in high-density lipoprotein cholesterol - PubMed

1 Department of Endocrinology and Metabolism, Dokkyo Medical University, Japan. Electronic address: jojima@dokkyomed.ac.jp. 2 Department of Endocrinology and Metabolism, Dokkyo Medical University, Japan. 3 Department of Infection Control and Clinical ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33556413/

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Lipid Level, Lipid Variability, and Risk of Multiple Myeloma: A Nationwide Population-Based Study of 3,527,776 Subjects

Aldo M. Roccaro, Academic Editor There is preclinical evidence that abnormalities in lipid metabolism promote cancer development, and a few studies show the association between lipid levels and multiple myeloma ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866996/

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Effect of Lactobacillus rhamnosus Probiotic in Early Pregnancy on Plasma Conjugated Bile Acids in a Randomised Controlled Trial - PubMed

We have previously shown that probiotic supplementation with Lactobacillus rhamnosus HN001 (HN001) led to a reduced incidence of gestational diabetes mellitus (GDM). Here we investigate whether HN001 supplementation resulted in ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33450885/

Fifty-Five-Year-Old Male Presents With a Complicated History

The patient is a non-smoker, eats a diet that is low in fats and carbohydrates and exercises often. He weighs 193 pounds, stands ..... see more

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  • from Doctor Unite 1 week 4 days
    This patient is clearly at an elevated cardiovascular risk. He is still above an ideal BMI. He needs to continue to work with diet and exercise to reduce Show More
  • from Doctor Unite 2 weeks 2 days
    change diet and life style and repeat in 1 month
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Bempedoic Acid in the Treatment of Patients with Dyslipidemias and Statin Intolerance

An elevated plasma low-density lipoprotein cholesterol (LDL-C) level is a well-established atherosclerotic cardiovascular disease (ACSVD) risk factor. Randomized studies with statins (alone or in combination with other lipid-lowering drugs) have ..... see more

Source : https://link.springer.com/article/10.1007/s10557-020-07139-x

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Elevated Lipids are Associated with Reduced Regional Brain Structure in Youth with Bipolar Disorder.

Objective Abnormal blood lipid levels are common in bipolar disorder (BD) and correlate with mood symptoms and neurocognition. However, studies have not examined the lipid-brain structure association in BD or ..... see more

Source : https://europepmc.org/article/med/33492669

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Echolucency of carotid plaque is useful for selecting high-risk patients with chronic coronary artery disease who benefit from intensive lipid-lowering therapy - PubMed

1 Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan. 2 Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Yamanashi, Japan. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33500186/

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Performance of Methods to Estimate Low-Density Lipoprotein Cholesterol in Women with and without HIV infection.

Background Low-density lipoprotein cholesterol (LDL-C) is estimated from total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) using predefined equations which assume fixed or varying relationships between these parameters ..... see more

Source : https://europepmc.org/article/med/33470728

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Reaching LDL-C Targets in Patients with Moderate, High, and Very High Risk for Cardiovascular Disease After Bariatric Surgery According to Different Guidelines

Background Cardiovascular disease (CVD) is highly prevalent in obese patients and is the leading cause of death. High levels of plasma low-density lipoprotein cholesterol (LDL-C) are associated with higher coronary ..... see more

Source : https://link.springer.com/article/10.1007/s11695-021-05221-3

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Obesity and Prediabetes are Jointly Associated with Lipid Abnormalitie | DMSO

Mohammad Almari, 1, * Anwar Mohammad, 2, * Jehad Abubaker, 2 Ali H Ziyab 3 1Department of Health Policy and Management, Faculty of Public Health, Kuwait University, Safat, Kuwait; 2Department ..... see more

Source : https://www.dovepress.com/obesity-and-prediabetes-are-jointly-associated-with-lipid-abnormalitie-peer-reviewed-article-DMSO

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The correlation between lipoprotein(a) and coronary atherosclerotic lesion is stronger than LDL-C, when LDL-C is less than 104 mg/dL

Background Lp(a) and LDL-C are both risk factors of atherosclerotic cardiovascular disease (ASCVD). But there was a contradiction point in LDL-C and Lp(a) control. The appropriate level of LDL-C and ..... see more

Source : https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-021-01861-6


New Patient Visit Reveals Surprises

A 64-year-old male presents to your clinic for a new patient visit. Though he does not complain of myalgia, you check his creatine ..... see more

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  • from Doctor Unite 3 weeks 3 days
    Nexletol which could help with his HbA1c.
  • 3 weeks 3 days
    I would not prescribe any statin until his current medication is clarified through old records or his pharmacy, as he may already be on a statin. Following that, I would Show More
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Effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Supplementation on Nutritional and Metabolic Parameters in the Early Postoperative Period after Roux-en-Y Gastric Bypass: a Randomized, Double-Blind, Placebo-Controlled Trial

Abstract Studies have suggested that Roux-en-Y gastric bypass (RYGB) causes changes in the intestinal microbiota composition and function due to anatomical and physiological modifications. The role of probiotic supplementation after ..... see more

Source : https://link.springer.com/article/10.1007/s11695-021-05222-2

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A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin - PubMed

doi: 10.1002/mgg3.1248. 1 Department of Life Sciences, Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London, United Kingdom. 2 Department of Medicine, Imperial College London, London, United Kingdom. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32307928/

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Improved lipid target level attainment in patients with peripheral artery disease - PubMed

It appears that there is more awareness and improvement of previously documented undertreatment of LDL-C levels in symptomatic PAD patients. Although statin treatment is initiated in the majority of patients, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33430734/

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Clinical Efficacy and Safety of Alirocumab after Acute Coronary Syndrome According to Achieved Level of Low-Density Lipoprotein Cholesterol: A Propensity Score-Matched Analysis of the ODYSSEY OUTCOMES Trial - PubMed

doi: 10.1161/CIRCULATIONAHA.120.049447. Online ahead of print. 1 Division of Cardiology, University of Colorado School of Medicine, Aurora, CO. 2 Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, INSERM U1148, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33438437/

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Association of lipid profile in migraine and non- migraine patients: an observational study

Anchal Bana Post Graduate Student, Department Of Ophthalmology, Muzaffarnagar Medical College, Muzaffarnagar, U.P, India Suman Bhartiya Professor and Head, Department Of Ophthalmology, Muzaffarnagar Medical College, Muzaffarnagar, U.P , India. Prachi ..... see more

Source : https://www.ijhcr.com/index.php/ijhcr/article/view/516

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The Association Between Statin Use and Outcomes in Patients Initiating Androgen Deprivation Therapy.

Studies have conflicting results regarding the association between statin use and biochemical recurrence for prostate cancer (PCa). A limited number of studies examining statins in advanced stages report positive results, ..... see more

Source : https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/127031-the-association-between-statin-use-and-outcomes-in-patients-initiating-androgen-deprivation-therapy.html

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Can Coronary Artery Calcium Scores Help to Personalize Risk Assessment and Tailor Treatment in Familial Hypercholesterolemia? - American College of Cardiology

Background Heterozygous familial hypercholesterolemia (HeFH) affects approximately one in 250 Americans, making it one of the most common genetic conditions associated with premature atherosclerotic cardiovascular disease (ASCVD). see more

Source : https://www.acc.org/latest-in-cardiology/articles/2020/11/30/12/48/can-coronary-artery-calcium-scores-help-to-personalize-risk-assessment

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Detection of Asymptomatic Carotid Artery Stenosis in High-Risk Individuals of Stroke Using a Machine-Learning Algorithm - PubMed

Objective Asymptomatic carotid stenosis (ACS) is closely associated to the incidence of severe cerebrovascular diseases. Early identifying the individuals with ACS and its associated risk factors could be beneficial for ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33413745/

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LDL-cholesterol change and goal attainment following statin intensity titration among Asians in primary care: a retrospective cohort study

Clinical trials have demonstrated that either initiating or up-titrating a statin dose substantially reduce Low-Density Lipoprotein-Cholesterol (LDL-C) levels. However, statin adherence in actual practice tends to be suboptimal, leading to ..... see more

Source : https://link.springer.com/article/10.1186/s12944-020-01427-z

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Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

Introduction: Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium is a trace element related to ..... see more

Source : https://europepmc.org/article/ppr/ppr262231

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Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells

The root of Platycodon grandiflorum (PG) has long been used as a traditional herbal medicine in Asian country. Platycondin D (PD), triterpenoid saponin that is a main constituent of PG, ..... see more

Source : https://www.nature.com/articles/s41598-020-76224-w

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Low-density lipoprotein cholesterol/apolipoprotein B ratio... : Coronary Artery Disease

n cholesterol (LDL-C) and apolipoprotein B (ApoB) ratio, ApoB, and CAC and compared the usefulness of the LDL-C/ApoB ratio and ApoB for diagnosing CAC. Methods A total of 10 357 subjects ..... see more

Source : https://journals.lww.com/coronary-artery/Abstract/9000/Low_density_lipoprotein_cholesterol_apolipoprotein.98738.aspx

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Association between SLC44A4 - NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

The current research was to assess the relationship of the solute carrier family 44 member 4 (SLC44A4) rs577272, notch receptor 4 (NOTCH4) rs3134931 SNPs and serum lipid levels in the ..... see more

Source : https://link.springer.com/article/10.1186/s12986-020-00533-0

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Nuclear magnetic resonance reveals postprandial low-density lipoprotein cholesterol determined by enzymatic method could be a misleading indicator - PubMed

Postprandial decline of LDL-C determined enzymatically was not confirmed by NMR-based methods. Indeed, there exists cholesterol redistribution in LDL subclasses following a meal. The decrease of postprandial PCSK9 may be ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33333042/

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LDL Cholesterol and Risk of MI and ASCVD in Adults ≥70 Years - American College of Cardiology

Elevated LDL cholesterol is associated with increased ASCVD risk among adults ≥70 years of age. The risk of elevated LDL and ASCVD was greatest among those ≥70 years of age. ..... see more

Source : https://www.acc.org/latest-in-cardiology/journal-scans/2020/12/03/20/50/elevated-ldl-cholesterol-and-increased

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Pathophysiology and Management of Dyslipidemias Associated with Insulin-Resistant States

Kevin C. Maki Lane Benes Mary R. Dicklin Part of the Contemporary Cardiology book series (CONCARD) Insulin resistance (IR), an impaired ability of circulating insulin to promote clearance of glucose ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-56514-5_16

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Proprotein Convertase Subtilisin/Kexin Type 9: Functional Role in Lipid Metabolism and Its Therapeutic Inhibition

Peter P. Toth Part of the Contemporary Cardiology book series (CONCARD) Proprotein convertase/kexin type 9 (PCSK9) is produced and secreted by hepatocytes. Once in the extracellular milieu, PCSK9 can bind ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-56514-5_14

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When is LDL Cholesterol Too Low?

Background: Familial hypobetalipoproteinemia (FHBL) is a rare genetic disorder that causes unusually low levels of LDL-C and apolipoprotein B (apoB). There are higher incidences of FHBL in pediatric patients with ..... see more

Source : https://unthsc-ir.tdl.org/handle/20.500.12503/30175

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Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis

Background There is growing evidence that serum lipid concentrations may be associated with attempted suicide in patients with major depressive disorder (MDD), but these findings remain controversial. Thus, we performed ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243847

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Association Between the Level of Low-Density Lipoprotein Cholesterol and Coronary Atherosclerosis in Patients Who Have Undergone Coronary Computed Tomography Angiography | Inoue | Cardiology Research

Association Between the Level of Low-Density Lipoprotein Cholesterol and Coronary Atherosclerosis in Patients Who Have Undergone Coronary Computed Tomography Angiography Hiroko Inoue a, c, Yuhei Shiga b, c, Kohei Tashiro ..... see more

Source : https://www.cardiologyres.org/index.php/Cardiologyres/article/view/1180/1161

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GOLIATH regulates LDLR availability and plasma LDL cholesterol levels

Increasing the availability of hepatic low-density lipoprotein receptors (LDLR) remains a major clinical target for reducing circulating plasma LDL cholesterol (LDL-C) levels. Here, we identify the molecular mechanism underlying genome-wide ..... see more

Source : https://www.biorxiv.org/content/10.1101/2020.12.09.415323v1