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Dyslipidemia and cardiovascular disease risk among the MASHAD study population

Dyslipidemia and cardiovascular disease risk among the MASHAD study population

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01204-y

Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an .....

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Lipoprotein profiling in early multiple sclerosis patients: effect of chronic inflammation?

Lipoprotein profiling in early multiple sclerosis patients: effect of chronic inflammation?

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01221-x

Inflammatory cytokines contribute to proatherogenic changes in lipid metabolism by reduction of HDL-cholesterol (HDL-C) levels, impairment of its antiinflammatory and antioxidant functions. Therefore, the protective actions of HDL-C can be .....

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Genes Associated With Inflammation May Serve as Biomarkers for the Diagnosis of Coronary Artery Disease and Ischaemic Stroke - PubMed

Genes Associated With Inflammation May Serve as Biomarkers for the Diagnosis of Coronary Artery Disease and Ischaemic Stroke - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32164735/

The CXCL8, TNF, SOCS3 and TNFAIP3 associated with inflammation may serve as biomarkers for the diagnosis of CAD or IS. The possible mechanisms may involve the Toll-like receptor, TNF, NF-kappa .....

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Simultaneous determination of five essential amino acids in plasma of Hyperlipidemic subjects by UPLC-MS/MS

Simultaneous determination of five essential amino acids in plasma of Hyperlipidemic subjects by UPLC-MS/MS

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01216-8

Millions of adults have been reported with hyperlipemia in the world. It is still unclear whether the plasma level of essential amino acids (AAs) will be influenced by the hyperlipemia. .....

Case Study: 65-year-old obese man w/hx of diabetes presents w/high LDL and aversion to medication

History of present illness: A 65-year-old Caucasian man presents for routine annual check-up. He is .....

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Carbamylated Lipoproteins and Progression of Diabetic Kidney Disease - PubMed

Carbamylated Lipoproteins and Progression of Diabetic Kidney Disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32075807/

1 Department of Medicine, University of Hong Kong, Hong Kong, China and kcbtan@hku.hk. 2 Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China. 3 Department of Medicine, .....

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Statins Starve Cancer Cells to Death

Statins Starve Cancer Cells to Death

Source : https://www.hopkinsmedicine.org/news/newsroom/news-releases/statins-starve-cancer-cells-to-death

"There have been epidemiological indications that people who take statins long term have fewer and less aggressive cancers, and that statins can kill cancer cells in the laboratory, but our .....

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Caspase-1 as a regulatory molecule of lipid metabolism

Caspase-1 as a regulatory molecule of lipid metabolism

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01220-y

Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate .....

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Association between lipids and apolipoproteins on type 2 diabetes risk; moderating effects of gender and polymorphisms; the ATTICA study

Association between lipids and apolipoproteins on type 2 diabetes risk; moderating effects of gender and polymorphisms; the ATTICA study

Source : https://research.aston.ac.uk/en/publications/association-between-lipids-and-apolipoproteins-on-type-2-diabetes

Background and Aims Type 2 diabetes mellitus (T2DM) is a condition defined by hyperglycaemia, but also often presents with dyslipidaemia and suppressed HDL cholesterol. Mendelian randomization studies have suggested a .....

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Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Source : https://onlinelibrary.wiley.com/doi/abs/10.1002/ejlt.201900443

Hyperlipidemia is a common cardiovascular disease. At present, the influence of high fat diet (HFD) on this is being explored. Recently, vegetable oils rich in omega‐3 have been reported that .....

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Statins may reduce disease recurrence in patients with ulcerated primary melanoma

Statins may reduce disease recurrence in patients with ulcerated primary melanoma

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.19012

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between .....

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Understanding Strengths and Limitations of Different Methods of LDL-C Estimation - American College of Cardiology

Understanding Strengths and Limitations of Different Methods of LDL-C Estimation - American College of Cardiology

Source : https://www.acc.org/latest-in-cardiology/articles/2019/04/02/13/21/understanding-strengths-and-limitations-of-different-methods-of-ldl-c-estimation

Low-density lipoprotein-cholesterol (LDL-C) remains a key contributor to plaque formation and atherosclerotic cardiovascular disease (ASCVD). Measuring LDL-C by gold standard ultracentrifugation is time-intensive and expensive. As such, the Friedewald equation, .....

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Hyperlipidemia and Statins Use for the Risk of New Diagnosed Sarcopenia in Patients with Chronic Kidney: A Population-Based Study

Hyperlipidemia and Statins Use for the Risk of New Diagnosed Sarcopenia in Patients with Chronic Kidney: A Population-Based Study

Source : https://www.mdpi.com/1660-4601/17/5/1494

Background: Previous research found that statins, in addition to its efficiency in treating hyperlipidemia, may also incur adverse drug reactions, which mainly include myopathies and abnormalities in liver function. Aim: .....

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European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity in: European Journal of Endocrinology Volume 182 Issue 1 (2020)

European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity in: European Journal of Endocrinology Volume 182 Issue 1 (2020)

Source : https://eje.bioscientifica.com/view/journals/eje/182/1/EJE-19-0893.xml

Obesity is an emerging condition, with a prevalence of ~20%. Although the simple measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and there are .....

Sixty-five-year-old Male With LDL of 168 mg/dL

A 65-year-old male patient of yours has a history of stroke, type 2 diabetes and elevated liver transaminases. He was most recently .....

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Impact of Baseline LDL-C and Lp(a) Elevation on Coronary Revascularization in Patients with Acute Coronary Syndrome One-Year after First Percutaneous Coronary Intervention

Source : https://www.scirp.org/journal/paperinformation.aspx?paperid=98403

Objective: The aim of this study was to investigate the effect of Lipoprotein-a [Lp(a)] on Coronary Revascularizaton (CR) on one year follow up in patients with Acute Coronary Syndrome (ACS) .....

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Effect of alirocumab on individuals with type 2 diabetes, high triglycerides, and low high-density lipoprotein cholesterol

Effect of alirocumab on individuals with type 2 diabetes, high triglycerides, and low high-density lipoprotein cholesterol

Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-0991-1

Mixed dyslipidemia [elevated non-high-density lipoprotein cholesterol (non-HDL-C) and triglycerides (TGs), and decreased HDL-C] is common in type 2 diabetes mellitus (T2DM) and is associated with increased cardiovascular risk. Non-HDL-C and .....

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LDL-C plays a causal role on T2DM: a Mendelian randomization analysis.

LDL-C plays a causal role on T2DM: a Mendelian randomization analysis.

Source : https://www.ncbi.nlm.nih.gov/pubmed/32040442

Aging (Albany NY). 2020 Feb 10;12(3):2584-2594. doi: 10.18632/aging.102763. Epub 2020 Feb 10.

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Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease - PubMed

Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32049305-association-of-monogenic-vs-polygenic-hypercholesterolemia-with-risk-of-atherosclerotic-cardiovascular-disease/

1 Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada. 2 Experimental Medicine Program, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. 3 .....

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Plant-based relatives of cholesterol could help gene therapy for cystic fibrosis, other diseases

Plant-based relatives of cholesterol could help gene therapy for cystic fibrosis, other diseases

Source : https://today.oregonstate.edu/news/plant-based-relatives-cholesterol-could-help-gene-therapy-cystic-fibrosis-other-diseases

PORTLAND, Ore. - Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol, new research shows. That's because the shape and structure of the phytosterols .....

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The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study

The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-1191-4

It is believed that deposition of amyloid beta (Aβ) in the brain is the central pathological changes of Alzheimer's disease (AD), which triggers a series of pathological processes. However, the .....

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The sensibility of the new blood lipid indicator--atherogenic index of plasma (AIP) in menopausal women with coronary artery disease

The sensibility of the new blood lipid indicator--atherogenic index of plasma (AIP) in menopausal women with coronary artery disease

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01208-8

Dyslipidemia is a key driver of coronary artery disease (CAD) development. This study aimed to determine whether the atherogenic index of plasma (AIP), a novel comprehensive lipid index, is an .....

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Curbside Consult: 56-year-old patient on high dosage of metformin

A 56-year-old African-American woman came to the clinic. She has had type II diabetes since she turned 40 .....

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Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8

Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....

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Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8

Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....

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Statins may lower mortality in high-risk prostate cancer patients

Statins may lower mortality in high-risk prostate cancer patients

Source : https://www.eurekalert.org/pub_releases/2020-02/tju-sml021020.php

PHILADELPHIA - Among high-risk prostate cancer patients - those with high PSA and Gleason scores of 8 or more - many will develop a difficult-to-treat disease. Preliminary research suggests that .....

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Association Between Obstructive Sleep Apnea and Lipid Metabolism During REM and NREM Sleep - PubMed

Association Between Obstructive Sleep Apnea and Lipid Metabolism During REM and NREM Sleep - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/32003732-association-between-obstructive-sleep-apnea-and-lipid-metabolism-during-rem-and-nrem-sleep/

1 Department of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China. 2 Otolaryngological Institute .....

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Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8

Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....

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Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes

Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744677/

The role of apolipoprotein E gene (APOE) in lipid metabolism has been well established, and APOE is associated with the risk of cardiovascular disease (CVD) and diabetes mellitus (DM). However, .....

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Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6

Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1710063

(2020). Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6. OncoImmunology: Vol. 9, No. 1, 1710063.

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A 32-year-old female, Amber, is a non-smoker with a history of familial hypercholesterolemia (FH). Her father underwent a coronary artery bypass grafting (CABG) at the age of 38 and has .....

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The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

Source : https://www.mdpi.com/1420-3049/25/2/271/htm

Curcumin is the main secondary metabolite of Curcuma longa and other Curcuma spp, and has been reported to have some potential in preventing and treating some physiological disorders. This study .....

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HDL-cholesterol and breast cancer risk

HDL-cholesterol and breast cancer risk

Source : https://news.vumc.org/2020/01/23/hdl-breast-cancer-risk/

Circulating lipids have been proposed to influence the risk of breast, colorectal and other common cancers, but results from conventional epidemiologic studies have been inconsistent. Alicia Beeghly-Fadiel, PhD, Nikhil Khankari, .....

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Improving cardiovascular health of the most vulnerable

Improving cardiovascular health of the most vulnerable

Source : https://medicalxpress.com/news/2020-01-cardiovascular-health-vulnerable.html

Starting in 2016, a two-year partnership between the North Carolina Chapter of the American College of Cardiology (NCACC) and the North Carolina Association of Free and Charitable Clinics (NCAFCC) provided .....

A patient, 60 and male, came into the clinic today. We did an annual exam, looking at cholesterol and other factors. The patient's LDL levels were high, and HDL levels .....

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Commented on a Post

Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD

Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD

Source : https://cjasn.asnjournals.org/content/15/1/47

Background and objectives Triglyceride-rich lipoproteins may contribute to the high cardiovascular risk of patients with CKD. This study evaluated associations of apo-B and markers of triglyceride-rich lipoproteins with cardiovascular events .....

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Commented on a Post

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment

Source : https://www.mdpi.com/1420-3049/25/2/271/htm

Curcumin is the main secondary metabolite of Curcuma longa and other Curcuma spp, and has been reported to have some potential in preventing and treating some physiological disorders. This study .....

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Commented on a Post

Hyperlipidemia affects tight junctions and pump function in the corneal endothelium.

Hyperlipidemia affects tight junctions and pump function in the corneal endothelium.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31945314

Am J Pathol. 2020 Jan 13. pii: S0002-9440(20)30006-7. doi: 10.1016/j.ajpath.2019.11.008. [Epub ahead of print]

Effects of intensive lipid-lowering therapy on mortality after coronary bypass surgery: A meta-analysis of 7 randomised trials.

Effects of intensive lipid-lowering therapy on mortality after coronary bypass surgery: A meta-analysis of 7 randomised trials.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31865057

BACKGROUND AND AIMS: The recent reported analysis from the ODYSSEY OUTCOMES trial showed that patients with previous coronary bypass graft surgery (CABG) had enhanced clinical benefits in response to intensive .....

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Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis

Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/coa.13421

To define the impact of hyperlipidemia as a coexisting factor on the prognosis of Idiopathic Sudden Sensorineural Hearing Loss (ISSHL), we prospectively analysed the Lipid‐lowering therapy Group (LLTG) data compared .....

Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene

Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1183-4

Use of ezetimibe on top of statin therapy has been shown to be effective to reduce LDL cholesterol level in hypercholesterolemic patients. However, little is known regarding the individual variety .....

Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders

Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1173-6

Adipogenesis is the process of adipocytes formation from unspecialized progenitor cells called mesenchymal stromal cells. Numerous mechanisms including epigenetic regulation modulate the correct progress of this process.