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History and Present Illness 

Patient is a 42-year-old female that presented for a physical after three years with no medical care. She is obese, and rationalizes a 45-pound weight gain, .....

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Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development

Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development

Source : https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvz253/5582659?searchresult=1

Atherosclerosis represents the most common cause of cardiovascular diseases. A prominent risk factor for atherosclerosis is hyperlipidaemia, i.e. high levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) in the .....

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Positive effects of low LDL-C and statins on bone mineral density: an integrated epidemiological observation analysis and Mendelian Randomization study

Positive effects of low LDL-C and statins on bone mineral density: an integrated epidemiological observation analysis and Mendelian Randomization study

Source : https://www.biorxiv.org/content/10.1101/531137v2.abstract

Background: Low-density lipoprotein cholesterol (LDL-C) is suggested to play a role in osteoporosis but its association with bone metabolism remains unclear. Effects of LDL-C-lowering drugs on bone are also controversial. .....

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Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial

Differences in lipid metabolism between anagliptin and sitagliptin in patients with type 2 diabetes on statin therapy: a secondary analysis of the REASON trial

Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-019-0965-3

Anagliptin, a dipeptidyl peptidase-4 inhibitor, is reported to reduce the level of low-density lipoprotein cholesterol (LDL-C). The underlying mechanism of this effect and effect on lipid metabolism however remains uncertain. .....

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High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.

Source : https://europepmc.org/article/med/31074720

OBJECTIVES:In this study, we used hypercholesterolaemic apolipoprotein E-deficient (Apoe-/-) mice to investigate LDL/oxLDL effect on synovial inflammation and cartilage destruction during antigen-induced arthritis (AIA). Further, as macrophage FcγRs are crucial .....

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Research reveals no link between statins and memory loss

Research reveals no link between statins and memory loss

Source : https://www.sciencedaily.com/releases/2019/11/191118190838.htm

Findings from more than 1,000 elderly individuals assessed over six years have revealed no links between statin medication and cognitive decline, such as memory loss, presenting new advice amidst some .....

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A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke

Source : https://www.nejm.org/doi/full/10.1056/NEJMoa1910355

Our apologies. An error occurred while setting your user cookie. Please set your browser to accept cookies to continue. NEJM.org uses cookies to improve performance by remembering your session ID .....

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Risk of Cardiovascular Events in Patients with Hypertriglyceridemia: A Review of Real‐World Evidence

Risk of Cardiovascular Events in Patients with Hypertriglyceridemia: A Review of Real‐World Evidence

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.13921

Statin‐treated patients have substantial residual cardiovascular disease risk despite control of low‐density lipoprotein cholesterol. Other modifiable atherogenic lipids and lipoproteins, such as triglycerides and triglyceride‐rich lipoproteins, are likely responsible for .....

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Variable Effects Of LDL Subclasses Of Cholesterol On Endothelial Nitri | IJN

Variable Effects Of LDL Subclasses Of Cholesterol On Endothelial Nitri | IJN

Source : https://www.dovepress.com/variable-effects-of-ldl-subclasses-of-cholesterol-on-endothelial-nitri-peer-reviewed-article-IJN

Variable Effects Of LDL Subclasses Of Cholesterol On Endothelial Nitric Oxide/Peroxynitrite Balance - The Risks And Clinical Implications For Cardiovascular Disease Jiangzhou Hua , Tadeusz Malinski Nanomedical Research Laboratory, Ohio .....

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History and Present Illness 
Patient is a 42-year-old female that presented for a physical after three years with no medical care. She is obese, and rationalizes a 45-pound weight gain, stating .....

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Bempedoic Acid, the Next LDL Cholesterol-Lowering Medication to Join the Arsenal? Insights From the CLEAR Wisdom Trial - American College of Cardiology

Bempedoic Acid, the Next LDL Cholesterol-Lowering Medication to Join the Arsenal? Insights From the CLEAR Wisdom Trial - American College of Cardiology

Source : https://www.acc.org/latest-in-cardiology/articles/2019/05/03/10/20/bempedoic-acid-the-next-ldl-cholesterol-lowering-medication-to-join-the-arsenal

Recent developments in low-density lipoprotein cholesterol (LDL-C) lowering could mean even more treatment options for our patients. The mainstay, statin therapy, acts on HMG-CoA reductase to reduce cholesterol synthesis, in .....

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Diagnosis of osteoporosis in statin-treated patients is dose-dependent

Diagnosis of osteoporosis in statin-treated patients is dose-dependent

Source : https://ard.bmj.com/content/78/12/1706

Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this study was set out to .....

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Initial serum cholesterol level as a potential marker for post cardiac arrest patient outcomes.

Initial serum cholesterol level as a potential marker for post cardiac arrest patient outcomes.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31711917

Resuscitation. 2019 Nov 8. pii: S0300-9572(19)30686-0. doi: 10.1016/j.resuscitation.2019.11.003. [Epub ahead of print]

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Research reveals no link between statins and memory loss

Research reveals no link between statins and memory loss

Source : https://newsroom.unsw.edu.au/news/science-tech/research-reveals-no-link-between-statins-and-memory-loss

Findings from more than 1,000 elderly individuals assessed over six years have revealed no links between statin medication and cognitive decline, such as memory loss, presenting new advice amidst some .....

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Association of preterm birth with lipid disorders in early adulthood: A Swedish cohort study

Association of preterm birth with lipid disorders in early adulthood: A Swedish cohort study

Source : https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002947

Author summary Why was this study done? Preterm birth has previously been linked with cardiovascular disease (CVD) in adulthood, but associations with lipid disorders (major risk factors for CVD) have .....

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Low-density lipoprotein cholesterol levels are positively associated with the risk of endobronchial biopsy-induced refractory hemorrhage in patients with lung cancer

Low-density lipoprotein cholesterol levels are positively associated with the risk of endobronchial biopsy-induced refractory hemorrhage in patients with lung cancer

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827240/

Lipoprotein concentrations have been associated with the major risk of bleeding events. However, whether plasma levels of LDL-C are associated with the risk of biopsy-related endobronchial hemorrhage remain elusive. Therefore, .....

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Trajectories of Lipids Profile and Incident Cardiovascular Disease Risk: A Longitudinal Cohort Study.

Trajectories of Lipids Profile and Incident Cardiovascular Disease Risk: A Longitudinal Cohort Study.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31630587

J Am Heart Assoc. 2019 Nov 5;8(21):e013479. doi: 10.1161/JAHA.119.013479. Epub 2019 Oct 19.

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Monocyte to high-density lipoprotein cholesterol ratio as long-term prognostic marker in patients with coronary artery disease undergoing percutaneous coronary intervention

Monocyte to high-density lipoprotein cholesterol ratio as long-term prognostic marker in patients with coronary artery disease undergoing percutaneous coronary intervention

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1116-2

The relation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) remains controversial. The present study aims to assess the prognostic .....

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Atorvastatin in combination with conventional antimicrobial treatment of Helicobacter pylori eradication: A randomized controlled clinical trial.

Atorvastatin in combination with conventional antimicrobial treatment of Helicobacter pylori eradication: A randomized controlled clinical trial.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31359499

BACKGROUND AND AIM: Helicobacter pylori is one of the main causes of digestive diseases, which is difficult to treat and requires the administration of several antimicrobial agents. Considering the anti-inflammatory .....

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Suboptimal treatment of dyslipidemia in patients with nonalcoholic fatty liver disease

Suboptimal treatment of dyslipidemia in patients with nonalcoholic fatty liver disease

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.14794

Corresponding Author https://orcid.org/0000-0002-9105-5837 Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Correspondence Dr Wah Kheong Chan, Gastroenterology and Hepatology Unit, Department of .....

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Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling

Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1136-y

Steatosis is an important clinical manifestation associated with chronic hepatitis C virus (HCV) infection. AMP-activated protein kinase (AMPK), a major mediator of lipid metabolism, regulates HCV-associated hepatic steatosis, but the .....

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Low-density lipoprotein cholesterol levels are positively associated with the risk of endobronchial biopsy-induced refractory hemorrhage in patients with lung cancer

Low-density lipoprotein cholesterol levels are positively associated with the risk of endobronchial biopsy-induced refractory hemorrhage in patients with lung cancer

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1140-2

Lipoprotein concentrations have been associated with the major risk of bleeding events. However, whether plasma levels of LDL-C are associated with the risk of biopsy-related endobronchial hemorrhage remain elusive. Therefore, .....

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History of Present Illness 
The patient is a 55-year-old obese female with Type 2 diabetes. She was referred to endocrinology by her primary care physician after the PCP obtained lab results .....

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Long-Term Efficacy and Safety of Evolocumab in Patients With Hypercholesterolemia

Long-Term Efficacy and Safety of Evolocumab in Patients With Hypercholesterolemia

Source : http://www.onlinejacc.org/content/74/17/2132

Background Evolocumab and other anti-PCSK9 antibodies reduced adverse cardiovascular outcomes in clinical trials of high-risk patients over

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Trajectories of Lipids Profile and Incident Cardiovascular Disease Risk: A Longitudinal Cohort Study

Trajectories of Lipids Profile and Incident Cardiovascular Disease Risk: A Longitudinal Cohort Study

Source : https://ahajournals.org/doi/10.1161/JAHA.119.013479

Clinical Perspective What Is New? Lipids can be jointly grouped into 3 distinct trajectory classes, and the trajectory group membership was associated with the risk of incident cardiovascular disease. Incremental .....

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Monocyte to high-density lipoprotein cholesterol ratio as long-term prognostic marker in patients with coronary artery disease undergoing percutaneous coronary intervention

Monocyte to high-density lipoprotein cholesterol ratio as long-term prognostic marker in patients with coronary artery disease undergoing percutaneous coronary intervention

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1116-2

The relation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) remains controversial. The present study aims to assess the prognostic .....

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Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database

Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database

Source : https://onlinelibrary.wiley.com/doi/full/10.1111/jgs.16227

Geert J. Lefeber MD Corresponding Author E-mail address: g.j.lefeber@umcutrecht.nl https://orcid.org/0000-0003-3045-5332 Department of Geriatrics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands Expertise Centre Pharmacotherapy in Old Persons, Utrecht, The .....

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Prestroke statins use reduces oxidized low density lipoprotein levels and improves clinical outcomes in patients with atrial fibrillation related acute ischemic stroke

Prestroke statins use reduces oxidized low density lipoprotein levels and improves clinical outcomes in patients with atrial fibrillation related acute ischemic stroke

Source : https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1463-7

Atrial fibrillation (AF) is a common cause of cerebral infarction, which could lead to endothelial dysfunction, increased reactive oxygen species (ROS) and oxidized low density lipoprotein (Ox-LDL).AF is associated with .....

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A 30-year-old female presented after developing angina while breastfeeding her child.  She was a non-smoker, but had a family history of hypercholesterolemia.  Her low-density lipoprotein cholesterol (LDL-C) was 419 mg/dL, and her .....

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Metformin, aspirin and statin and risk of cancer: A population-based study in Thailand.

Metformin, aspirin and statin and risk of cancer: A population-based study in Thailand.

Source : https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.e13095

e13095 Background: : There were the conflicted results of the association of ASA, metformin or statin and risk of cancer in the previous studies. This is a population-based study in .....

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Association of intracellular lipid accumulation in subcutaneous adipocyte precursors and plasma adipokines in bariatric surgery candidates

Association of intracellular lipid accumulation in subcutaneous adipocyte precursors and plasma adipokines in bariatric surgery candidates

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1081-9

The adipocyte expansion is a critical process with implications in the pathogenesis of obesity associated metabolic syndrome. Impaired adipogenesis leads to dysfunctional, hypertrophic adipocytes, local inflammation and peripheric insulin resistance.

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Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

Apolipoprotein A1 is associated with SYNTAX score in patients with a non-ST segment elevation myocardial infarction

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1101-9

The study was designed to investigate lipid profile and SYNTAX score in patients with non-ST segment elevation myocardial infarction (NSTEMI). 311 patients with NSTEMI were enrolled. The demographic, clinical data, .....

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Association of statin use with risk of Gleason score-specific prostate cancer: A hospital-based cohort study.

Association of statin use with risk of Gleason score-specific prostate cancer: A hospital-based cohort study.

Source : https://www.ncbi.nlm.nih.gov/pubmed/31595713

BACKGROUND: Conflicting evidence suggests that statins act chemopreventively against prostate cancer (PCa). Whether the association of statin use with PCa risk is Gleason score-dependent, time-, dose-respondent is not well studied. .....

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Is the coronary artery calcium score the first-line tool for investigating patients with severe hypercholesterolemia?

Is the coronary artery calcium score the first-line tool for investigating patients with severe hypercholesterolemia?

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1090-8

Coronary artery calcium (CAC) is known as a reliable tool for estimating risk of myocardial infarction, coronary death, all-cause mortality and is even used to evaluate suitable asymptomatic patients. We .....

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Elevated triglyceride-to-HDL cholesterol ratio is an indicator for insulin resistance in middle-aged and elderly Taiwanese population: a cross-sectional study

Elevated triglyceride-to-HDL cholesterol ratio is an indicator for insulin resistance in middle-aged and elderly Taiwanese population: a cross-sectional study

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1123-3

Previous studies have reported that the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio could be a simple clinical indicator of insulin resistance (IR), but the results indicated that there were .....

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Comparison of discrimination for cardio-metabolic risk by different cut-off values of the ratio of triglycerides to HDL cholesterol

Comparison of discrimination for cardio-metabolic risk by different cut-off values of the ratio of triglycerides to HDL cholesterol

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1098-0

The ratio of triglycerides to HDL cholesterol (TG/HDL-C ratio) is known as a good predictor for cardiovascular disease. The purpose of this study was to compare discrimination for cardiovascular risk .....

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Statins Linked to Higher Risk of Diabetes and Skin Infections

Statins Linked to Higher Risk of Diabetes and Skin Infections

Source : https://newsroom.wiley.com/press-release/british-journal-clinical-pharmacology/statins-linked-higher-risk-diabetes-and-skin-inf

Statins have been reported to be beneficial for infections such as pneumonia and Staphylococcus aureus bacteraemia. In the case of skin and soft tissue infections however, statin use is ironically .....

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Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy

Source : https://www.nejm.org/doi/full/10.1056/NEJMoa1815111

Our apologies. An error occurred while setting your user cookie. Please set your browser to accept cookies to continue. NEJM.org uses cookies to improve performance by remembering your session ID .....

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Statin Use in Primary Prevention of ASCVD According to 5 Guidelines - American College of Cardiology

Statin Use in Primary Prevention of ASCVD According to 5 Guidelines - American College of Cardiology

Source : https://www.acc.org/latest-in-cardiology/journal-scans/2019/10/08/11/49/statin-use-in-primary-prevention-of-atherosclerotic

Is there a difference in the sensitivity, specificity, and estimated number needed to treat (NNT 10) with a statin to prevent one atherosclerotic cardiovascular disease (ASCVD) event in 10 years .....