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A Meta-Analysis Assessing Additional LDL-C Reduction From Addition of a Bile Acid Sequestrant to Statin Therapy - PubMed

Background: Statins are the first line therapy for reducing low-density lipoprotein cholesterol (LDL-c). However, there are secondary prevention patients who are either intolerant to maximal statin therapy or do not ..... see more

Source : https://www.ncbi.nlm.nih.gov/pubmed/32416177

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Higher ANGPTL3, apoC-III, and apoB48 Dyslipidemia, and Lower Lipoprotein Lipase Concentrations Are Associated With Dysfunctional Visceral Fat in Adolescents With Obesity - PubMed

Adolescents with obesity show higher ANGPTL3 compounded with increased apoC-III associated with increased CR and lower LPL mass. This is associated with inflammation and visceral fat. The significance of these ..... see more

Source : https://www.ncbi.nlm.nih.gov/pubmed/32407781

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Prevalence of residual inflammatory risk and associated clinical variables in patients with type 2 diabetes mellitus

Cookies are disabled for this browser. Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information ..... see more

Source : https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/dom.14081

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Statin use and lung cancer risk in chronic obstructive pulmonary disease patients: a population-based cohort study

Patients living with chronic obstructive pulmonary disease (COPD) are at an increased risk of lung cancer. A common comorbidity of COPD is cardiovascular disease; as such, COPD patients often receive ..... see more

Source : https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01344-w?utm_source=other&utm_medium=other&utm_content=null&utm_campaign=BSCN_2_DD01_CN_bmcso_article_paid_XMOL

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A Novel Variant in APOB Gene Causes Extremely Low LDL-C Without Known Adverse Effects

A novel frameshift variant was identified in APOB that segregates in a dominant manner with low levels of low-density lipoprotein cholesterol. Affected family members show no apparent clinical complications. There ..... see more

Source : https://casereports.onlinejacc.org/content/2/5/775

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Measuring LDL-cholesterol: what is the best way to do it? : Current Opinion in Cardiology

ion or measured with direct assays, these methods have limitations, particularly for patients with dyslipidaemias, low LDL-C, and hypertriglyceridemia. The focus of this review will be recent advances in the ..... see more

Source : https://journals.lww.com/co-cardiology/Abstract/9000/Measuring_LDL_cholesterol__what_is_the_best_way_to.98996.aspx

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Association of LDL-C/HDL-C Ratio With Stroke Outcomes Within 1 Year After Onset: A Hospital-Based Follow-Up Study

Stroke remains a leading cause of death and disability. The low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C ratio) ratio has been confirmed to be a predictor of stroke. However, ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fneur.2020.00408/full

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Progress in the seasonal variations of blood lipids: a mini-review

The seasonal variations of blood lipids have recently gained increasing interest in this field of lipid metabolism. Elucidating the seasonal patterns of blood lipids is particularly helpful for the prevention ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01237-3

A 32-year-old patient with type II diabetes came into the office complaining of some trouble breathing and staying energized throughout the day. Knowing that there is cardiovascular risk to patients ..... see more

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Serum leptin levels are positively associated with aortic stiffness in patients with chronic kidney disease stage 3-5

ABSTRACT ABSTRACT Leptin potentially exerts atherogenic effects.This study evaluated the relationship between serum leptin levels and aortic stiffness in patients with stage 3-5 chronic kidney disease (CKD). Totally 205 participants ..... see more

Source : https://www.tandfonline.com/doi/full/10.1080/21623945.2020.1764799

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Effect of Berberine Plus Bezafibrate Administration on the Lipid Profile of Patients With Mixed Dyslipidemia: A Pilot Clinical Trial - PubMed

To evaluate the effect of berberine (BBR) plus bezafibrate administration on the lipid profile of patients with mixed dyslipidemia. A double-blind randomized pilot clinical trial with parallel groups was carried ..... see more

Source : https://www.ncbi.nlm.nih.gov/pubmed/32397850

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Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin

Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ-mediated ..... see more

Source : https://heart.bmj.com/content/early/2020/05/12/heartjnl-2019-316165.long

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Association Between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels - PubMed

in this cohort of postmenopausal women, VLDL-C was significantly associated to carotid IMT, independent of main cardiovascular risk factors. These findings pave the way for targeting circulating concentrations of VLDL-C ..... see more

Source : https://www.ncbi.nlm.nih.gov/pubmed/32403373

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The LDL-C/HDL-C ratio and 4-year risk of coronary artery disease: a retrospective study

Abstract BackgroundNumerous studies have demonstrated that the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio can reflect the positive correlation index LDL-C and the negative index HDL-C of coronary artery disease ..... see more

Source : https://europepmc.org/article/ppr/ppr121976

Female Statin Patient With Muscle Cramping

A 62-year-old woman has a history of peripheral arterial disease and coronary artery disease had three stents placed over the past few years. ..... see more

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Hyperlipidemia is a risk factor for bladder cancer in young adult men: a population-based cohort study

Hyperlipidemia is a risk factor for bladder cancer in young adult men: a population-based cohort study see more

Source : https://europepmc.org/article/ppr/ppr152920

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Supplements of an aqueous combination of Justicia adhatoda and Ocimum tenuiflorum boost antioxidative effects and impede hyperlipidemia

Md. Atiar Rahman Corresponding Author E-mail address: atiar@cu.ac.bd Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong, Bangladesh Correspondence Md. Atiar Rahman, Department of Biochemistry and Molecular Biology, Faculty ..... see more

Source : https://onlinelibrary.wiley.com/doi/full/10.1002/ame2.12115

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divAbstract see more

Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

To better understand the mechanism of hyperlipidemia and discover potential biomarkers, we have used targeted metabolomics to analyze eight amino acid profiles of control and hyperlipidemia rats by a liquid ..... see more

Source : https://pubs.rsc.org/en/content/articlelanding/2020/ay/d0ay00305k/unauth

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Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk - American College of Cardiology

The FOURIER trial showed that evolocumab was superior to placebo at reducing adverse cardiovascular events. The goal of the trial was to evaluate the efficacy and safety of evolocumab, a ..... see more

Source : https://www.acc.org/latest-in-cardiology/clinical-trials/2017/03/16/00/46/fourier

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No Association Between Migraine Frequency and White Matter Lesions and Silent Brain Infarctions: A Study in a Series of Chronic Migraine Women - PubMed

As compared with the expected prevalence at this age, this study confirms that the prevalence of WML, in most cases small, deep and frontal, is increased in CM and EM. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32343863/

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divAbstract see more

Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

To better understand the mechanism of hyperlipidemia and discover potential biomarkers, we have used targeted metabolomics to analyze eight amino acid profiles of control and hyperlipidemia rats by a liquid ..... see more

Source : https://pubs.rsc.org/en/content/articlelanding/2020/ay/d0ay00305k/unauth

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The Effect of Probiotics Supplementation on Blood Pressure: A Systemic Review and Meta-Analysis - PubMed

doi: 10.1186/s12944-020-01259-x. 1 Department of Cardiology, Beijing Chao-Yang Hospital, No. 8 Gongti South Road, Chaoyang District, Beijing, 100043, China. 2 Children's Hospital, Capital Medical University, Beijing, China. 3 Department of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32334580/

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VARIANTS OF HYPERLIPIDEMIA IN CHILDREN WITH INSULIN RESISTANCE

Obesity in adults and children is characterized by epidemiological prevalence with a tendency to increase. Purpose of the study- to analyze the lipid profile in overweight children, depending on the ..... see more

Source : https://inter.knmu.edu.ua/article/view/331

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Effect of Milk Thistle on Hyperlipidemia: A Systematic Review

Sadeghi, Gholamreza and Mohammadzadeh, Fatemeh and Mazloum, Seyedreza (2020) Effect of Milk Thistle on Hyperlipidemia: A Systematic Review. Navid No, 22 (72). pp. 64-73. Introduction: Heart disease is the most ..... see more

Source : https://eprints.mums.ac.ir/18707/

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Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis - PubMed

1 From the TIMI (Thrombolysis in Myocardial Infarction) Study Group, Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (R.P.G., E.A.B., S.A.M., M.S.S.). 2 Oslo Universitetssykehus HF, Endocrinology-Morbid Obesity and Preventive ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32312223/

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Advanced Fibrosis of Non-Alcoholic Steatohepatitis Affects the Significance of Lipoprotein(a) as a Cardiovascular Risk Factor - PubMed

doi: 10.1016/j.atherosclerosis.2020.02.026. 1 Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan. 2 Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32203743/

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Circulating Oxidized LDL Increased in Patients With Acute Myocardial Infarction Is Accompanied by Heavily Modified HDL - PubMed

Oxidized low-density lipoprotein (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32291330/

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Tomato seed oil attenuates hyperlipidemia and modulates gut microbiota in C57BL/6J mice

In this study we aimed to investigate the role of tomato seed oil (TSO) in the alleviation of hyperlipidemia and the regulation of gut microbiota in C57BL/6J mice. see more

Source : https://pubs.rsc.org/en/content/articlehtml/2020/fo/d0fo00133c

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Two Phase 3 Trials of Inclisiran in Patients With Elevated LDL Cholesterol - PubMed

Reductions in LDL cholesterol levels of approximately 50% were obtained with inclisiran, administered subcutaneously every 6 months. More injection-site adverse events occurred with inclisiran than with placebo. (Funded by the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32187462/

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People with type 2 diabetes and heart disease may benefit from newer therapies

Coronary artery disease among people with type 2 diabetes may need to be treated more aggressively than in people with coronary artery disease who do not have diabetes. A new ..... see more

Source : https://www.sciencedaily.com/releases/2020/04/200413090751.htm

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Migraine and Ischemic Stroke in Women. A Narrative Review - PubMed

The commonality of factors associated with MWA and with MWA-associated stroke suggest that persons with secondary, ischemia-induced aura may be at elevated risk of stroke. Although further research is needed, ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32246455/

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The LDL-C/HDL-C ratio and 4-year risk of coronary artery disease: a retrospective study

BackgroundNumerous studies have demonstrated that the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio can reflect the positive correlation index LDL-C and the negative index HDL-C of coronary artery disease (CAD) ..... see more

Source : https://europepmc.org/article/ppr/ppr121976

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Increased risk of hyperlipidemia in patients with anxiety disorders: A population-based study

Increased risk of hyperlipidemia in patients with anxiety disorders: A population-based study see more

Source : https://europepmc.org/article/ppr/ppr130983

Forty-Two-Year-Old Male With Family History of Coronary Heart Disease

A 42-year-old male whose father and both grandfathers all had a myocardial infarction in their late 40s presents to you ..... see more

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Registration is now open!
COVID-19 Clinical Trials & Timelines
Thursday, 4/23 at 12:00 PM ET

COVID-19 Clinical Trials & Timelines

Join this live online lecture to hear experts discuss the increasing clinical trial activity in COVID-19 as industry ramps up research for treatments and vaccines. see more

Source : https://hopin.to/events/skipta-covid-trials?ref=85d9cda1b6d4

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The intake assessment of diverse dietary patterns on childhood hypertension: alleviating the blood pressure and lipidemic factors with low-sodium seafood rich in omega-3 fatty acids

Childhood hypertension (CH) is related to the dietary intake and diversity of children. The study aimed to assess the critical role of dietary diversity, and seafood long-chain n-3 polyunsaturated fatty ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01245-3

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The Effect of Synbiotics Supplementation on Anthropometric Indicators and Lipid Profiles in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial - PubMed

doi: 10.1186/s12944-020-01244-4. 1 Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2 Research Development Center, Arash Women's ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32248805/

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Real-world data, theoretical application of guidelines, cost, and access: how do we optimize non-statin therapy for LDL-C/non-HDL-C/ApoB?

You do not currently have access to this article. Subscription prices and ordering Real-world data, theoretical application of guidelines, cost, and access: how do we optimize non-statin therapy for LDL-C/non-HDL-C/ApoB? ..... see more

Source : https://academic.oup.com/eurheartj/article-abstract/doi/10.1093/eurheartj/ehaa139/5817949?redirectedFrom=fulltext

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The beneficial effects of nutraceuticals and natural products on small dense LDL levels, LDL particle number and LDL particle size: a clinical review

Cardiovascular diseases (CVDs) are globally the major causes of morbidity and mortality. Evidence shows that smaller and denser low-dense lipoprotein (sdLDL) particles are independent atherogenic risk factors for CVD due ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01250-6

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Effect of Arterial Hypertension and Hyperlipidemia on the Remodeling of Articular Cartilage and the Development of Osteoarthritis (Experimental Study)

Osteoarthritis (OA) is a degenerative inflammatory disease of the synovial joints associated with age, cardiovascular comorbidity, and other factors. It is based on articular cartilage (AC) and subchondral bone (SCB) ..... see more

Source : https://link.springer.com/article/10.1134/S2079057020010087

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Lipidomic profile and candidate biomarkers in septic patients

Sepsis is a severe disease with a high mortality rate. Identification and treatment in the initial hours of the disease improve outcomes. Some biomarkers like procalcitonin and C-reactive protein are ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01246-2

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Change in Glucose Intolerance Status and Risk of Incident Cardiovascular Disease: Tehran Lipid and Glucose Study - PubMed

Among participants with IFG, IGT or IFG/IGT at baseline, only those who developed diabetes had a higher risk of developing CVD/CHD. Persistent IFG/IGT was not associated with higher risk, compared ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32228577/

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A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases. Particularly in ischemic stroke (IS), the abnormal expression of MALAT1 played important roles including promotion of angiogenesis, inhibition of ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01236-4

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Neutrophil to High-Density Lipoprotein Ratio Has a Superior Prognostic Value in Elderly Patients With Acute Myocardial Infarction: A Comparison Study - PubMed

1 Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2 Second Clinical School, Tongji Hospital, Tongji Medical College, Huazhong University of Science ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32247314/

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Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome: Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of a Randomized Clinical Trial - PubMed

1 Division of Cardiology, University of Colorado School of Medicine, Aurora, CO. 2 Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, and INSERM-1148, Paris, France. 3 State University ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32223446/

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Why Patients With Familial Hypercholesterolemia Are at High Cardiovascular Risk? Beyond LDL-C Levels - PubMed

Familial hypercholesterolemia (FH) is a common genetic cause of elevated low-density lipoprotein cholesterol (LDL-C) due to defective clearance of circulating LDL particles. All FH patients are at high risk for ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/32205033/