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Proprotein Convertase Subtilisin/Kexin Type 9: Functional Role in Lipid Metabolism and Its Therapeutic Inhibition

Peter P. Toth Part of the Contemporary Cardiology book series (CONCARD) Proprotein convertase/kexin type 9 (PCSK9) is produced and secreted by hepatocytes. Once in the extracellular milieu, PCSK9 can bind ..... see more

Source : https://link.springer.com/chapter/10.1007/978-3-030-56514-5_14

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When is LDL Cholesterol Too Low?

Background: Familial hypobetalipoproteinemia (FHBL) is a rare genetic disorder that causes unusually low levels of LDL-C and apolipoprotein B (apoB). There are higher incidences of FHBL in pediatric patients with ..... see more

Source : https://unthsc-ir.tdl.org/handle/20.500.12503/30175

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Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis

Background There is growing evidence that serum lipid concentrations may be associated with attempted suicide in patients with major depressive disorder (MDD), but these findings remain controversial. Thus, we performed ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243847

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Association Between the Level of Low-Density Lipoprotein Cholesterol and Coronary Atherosclerosis in Patients Who Have Undergone Coronary Computed Tomography Angiography | Inoue | Cardiology Research

Association Between the Level of Low-Density Lipoprotein Cholesterol and Coronary Atherosclerosis in Patients Who Have Undergone Coronary Computed Tomography Angiography Hiroko Inoue a, c, Yuhei Shiga b, c, Kohei Tashiro ..... see more

Source : https://www.cardiologyres.org/index.php/Cardiologyres/article/view/1180/1161

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GOLIATH regulates LDLR availability and plasma LDL cholesterol levels

Increasing the availability of hepatic low-density lipoprotein receptors (LDLR) remains a major clinical target for reducing circulating plasma LDL cholesterol (LDL-C) levels. Here, we identify the molecular mechanism underlying genome-wide ..... see more

Source : https://www.biorxiv.org/content/10.1101/2020.12.09.415323v1

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Effects of whey protein on glycemic control and serum lipoproteins in patients with metabolic syndrome and related conditions: a systematic review and meta-analysis of randomized controlled clinical trials

This systematic review and meta-analysis aimed to assess the effects of whey protein on serum lipoproteins and glycemic status in patients with metabolic syndrome (MetS) and related disorders. see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01384-7

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Addressing Statin Intolerance In Practice: Moving Beyond the Controversy

Low-density lipoprotein cholesterol (LDL-C) has been shown to be atherogenic and likely have a causal relationship for the development of atherosclerotic cardiovascular disease (ASCVD). 1 Thus, reducing LDL-C levels is ..... see more

Source : https://www.cardiometabolichealth.org/addressing-statin-intolerance-in-practice-moving-beyond-the-controversy.html

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need for PCSK9 inhibitors and associated treatment costs according to the 2019 ESC dyslipidaemia guidelines vs. the risk-based allocation algorithm of the 2017 ESC consensus statement: a simulation study in a contemporary CAD cohort

The accumulation of low-density lipoprotein cholesterol (LDL-C) in the vascular wall initiates and maintains the atherosclerotic cascade. In particular for patients with prevalent atherosclerotic cardiovascular disease (ASCVD), the reduction of ..... see more

Source : https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwaa088/6017060

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Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858

Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant rs1799858] and environmental [elevated serum low-density lipoprotein cholesterol (LDL-C) level] factors, ..... see more

Source : https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02639-8

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The effect of calcium supplement intake on lipid profile: a systematic review and meta-analysis of randomized controlled clinical trials

Abstract Despite the potential role of dietary calcium in fat excretion, the favorable effects of calcium supplements on lipid profile remains inconclusive. The current study aimed to review the effect ..... see more

Source : https://doi.org/10.1080/10408398.2020.1850414

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Assessment of Low LDL Cholesterol in Patients Treated by PCSK9 Inhibition: Comparison of Martin/Hopkins and Friedewald Estimations

Recent guidelines recommend further reduction of low-density lipoprotein cholesterol (LDL-C) in high-risk populations. The use of proprotein convertase subtilisin/kexin type-9 inhibitors (PCSK9i) enables many patients to achieve profound reduction in ..... see more

Source : https://link.springer.com/article/10.1007/s10557-020-07107-5

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Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects

Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease. Increasing evidence has shown that dyslipidemia-related cardiac damage is associated with lipid accumulation, oxidative stress, and inflammation. Thymoquinone (TQ) ..... see more

Source : https://doi.org/10.1155/2020/4878704

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Maternal plasma folate concentration is positively associated with serum total cholesterol and low-density lipoprotein across the three trimesters of pregnancy

Increased first-trimester low-density lipoprotein (LDL-C) concentration has been associated with adverse pregnancy outcomes, such as gestational diabetes. The B vitamins folate, B-6, and total B-12 are key for the methyl ..... see more

Source : https://www.nature.com/articles/s41598-020-77231-7

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Serum aromatic and branched‐chain amino acids associated with NASH demonstrate divergent associations with serum lipids

Päivi Pajukanta Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA Institute for Precision Health, School of Medicine, UCLA, ..... see more

Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.14743

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Emerging insights into the relationship between hyperlipidemia and the risk of diabetic retinopathy

Hyperlipidemia is correlated with a series of health problems. Notably, aside from its established role in promoting cardiovascular morbidity and mortality, hyperlipidemia has also been considered for modulating the risk ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01415-3

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Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33171638/

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Cholesterol lowering therapies and achievement of targets for primary and secondary cardiovascular prevention in type 2 diabetes: unmet needs in a large population of outpatients at specialist clinics

The well-established benefit of Low-Dense-Lipoprotein-cholesterol (LDL-c) lowering treatments (LLTs) has led clinical guidelines to lower the cardiovascular prevention targets. Despite this, there is a surprising scarcity of real-world studies (RWS) ..... see more

Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-01164-8

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PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort

Background Therapeutic inhibition of PCSK9 protects against coronary artery disease (CAD) and ischemic stroke (IS). The impact on other diseases remains less well characterized. Methods We created a genetic risk ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239752

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GENetic characteristics and REsponse to lipid-lowering therapy in familial hypercholesterolemia: GENRE-FH study

Among the 146 patients enrolled in the Korean FH registry, 83 patients who had undergone appropriate LLT escalation and were followed-up for ≥ 6 months were analyzed for pathogenic variants (PVs). The ..... see more

Source : https://www.nature.com/articles/s41598-020-75901-0

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Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects

Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease. Increasing evidence has shown that dyslipidemia-related cardiac damage is associated with lipid accumulation, oxidative stress, and inflammation. Thymoquinone (TQ) ..... see more

Source : https://www.hindawi.com/journals/bmri/2020/4878704/

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Effect of polyphenol-rich extra-virgin olive oil on lipid profile and inflammatory biomarkers in patients undergoing coronary angiography: a randomised, controlled, clinical trial

Abstract The present study was conducted to compare the effects of high polyphenol extra-virgin olive oil (EVOO) with low polyphenol refined olive oil (ROO) on some cardiovascular risk factors in ..... see more

Source : https://doi.org/10.1080/09637486.2020.1841123

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High-Sensitive C-reactive Protein and Atherogenic Lipid Levels in a Group of University Students with Habitual Smoking

Introduction The use of tobacco is increasing and broadly spreading throughout the world. It is a bad human behavior and is practiced by people when addicted to nicotine, which causes ..... see more

Source : https://biomedpharmajournal.org/vol13no3/high-sensitive-c-reactive-protein-and-atherogenic-lipid-levels-in-a-group-of-university-students-with-habitual-smoking/

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Intensive treat-to-target statin therapy and severity of diabetic retinopathy complicated by hypercholesterolaemia

To compare the effects of intensive and standard statin therapy on severity of diabetic retinopathy (DR) complicated by hypercholesterolaemia in a prespecified substudy of the standard vs. intEnsive statin therapy ..... see more

Source : https://www.nature.com/articles/s41433-020-01202-5

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Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33103936/

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Muscle Pain and Energy-Rich Blood: Cholesterol Medicine Affects the Organs Differently

Contrary to expectation, treatment with statins has a different effect on blood cells than on muscle cells, a new study from the University of Copenhagen reveals. Today, statins are mainly ..... see more

Source : https://healthsciences.ku.dk/newsfaculty-news/2020/10/muscle-pain-and-energy-rich-blood-cholesterol-medicine-affects-the-organs-differently/

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Clinical implications of the log linear association between LDL-C lowering and cardiovascular risk reduction: Greatest benefits when LDL-C >100 mg/dl

Background The log linear association between on-treatment LDL-C levels and ASCVD events is amplified in higher risk patient subgroups of statin versus placebo trials. Objectives Update previous systematic review to ..... see more

Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240166

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Could Fecal Microbiota Be a Useful Indicator of Serum Cholesterol Levels among Men?

Trepidation with blood tests among men may result in fewer routine screening and examination of their cardiovascular risk factors. Associations between fecal microbiota and serum cholesterols have not been well-established. ..... see more

Source : https://www.mdpi.com/2075-4426/10/4/175

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Differential DNA methylation in familial hypercholesterolemia

Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33096472/

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Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease

Contribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate see more

Source : https://link.springer.com/article/10.1007/s10072-020-04791-x

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Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease

Contribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate < 60 mL/min/1.73 m2) affects the association has not been investigated. ..... see more

Source : https://link.springer.com/article/10.1007/s10072-020-04791-x

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Ceramides Improve Atherosclerotic Cardiovascular Disease Risk Assessment beyond Standard Risk Factors - Clin. Chim. Acta - X-MOL

Ceramides are bioactive lipids that act as secondary messengers for both intra- and inter-cellular signaling. Elevated plasma concentrations of ceramides are associated with multiple risk factors of atherosclerotic cardiovascular diseases ..... see more

Source : https://www.x-mol.com/paper/1315811450139414528

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Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial

Elevated baseline levels of lipoprotein(a), a genetically determined low-density lipoprotein particle, have been associated with increased risk of cardiovascular events in epidemiological studies and Mendelian randomization analyses., In keeping with ..... see more

Source : https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaa649/5922803

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Time-of-day and meal size effects on clinical lipid markers

AbstractContext. Dyslipidemia and cardiovascular disease are common in shift workers and eating at night may contribute to this pathophysiology.Objective. To see more

Source : https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaa739/5922806

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LDL-C/HDL-C is associated with ischaemic stroke in patients with non-valvular atrial fibrillation: a case-control study

This study explored the relationships between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in patients with non-valvular atrial fibrillation (NVAF) in Xinjiang. The ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01392-7

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Dynamic Changes of Blood Lipids in Breast Cancer Patients After (Neo)a | IJGM

Liuyue Xu, 1 Qian Dong, 2 Yaoying Long, 1 Xiaoqiong Tang, 1 Nan Zhang, 2 Kai Lu 2 1Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing ..... see more

Source : https://www.dovepress.com/dynamic-changes-of-blood-lipids-in-breast-cancer-patients-after-neoadj-peer-reviewed-article-IJGM

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Pre-diagnostic plasma lipid levels and the risk of amyotrophic lateral sclerosis

Abstract To assess whether pre-diagnostic lipid levels are associated with Amyotrophic lateral sclerosis (ALS) risk. Methods: We conducted a matched case-control study nested in five large prospective US cohorts (the ..... see more

Source : https://www.tandfonline.com/doi/abs/10.1080/21678421.2020.1822411

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Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation - Clin. Biochem. - X-MOL

Lipoprotein(a) [Lp(a)] is a pro-atherogenic and pro-thrombotic LDL-like particle recognized as an independent risk factor for cardiovascular disease (CVD). The cholesterol within Lp(a) (Lp(a)-C) contributes to the reported LDL-cholesterol (LDL-C) ..... see more

Source : https://www.x-mol.com/paper/1310730423192752128

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Long-term prognostic utility of low-density lipoprotein (LDL) triglyceride in real-world patients with coronary artery disease and diabetes or prediabetes

Recent guidelines highlighted the association between atherosclerosis and triglyceride-enriched lipoproteins in patients with impaired glucose metabolism. However, evidence from prospective studies for long-term prognostic utility of low-density lipoprotein triglyceride (LDL-TG) ..... see more

Source : https://link.springer.com/article/10.1186/s12933-020-01125-1

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YKL-40 as a novel biomarker in cardio-metabolic disorders and inflammatory diseases - PubMed

Dyslipidaemia is associated with numerous health problems that include the combination of insulin resistance, hypertension and obesity, ie, metabolic syndrome. Although the use of statins to decrease serum low density ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/33002471/

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The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders

Due to changes in lifestyle, diet structure, and aging worldwide, the incidence of metabolic syndromes such as hyperlipidemia, hypertension, diabetes, and obesity is increasing. Metabolic syndrome is considered to be ..... see more

Source : https://www.hindawi.com/journals/ije/2020/8601796/

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LDL Cholesterol and Dysglycemia: an Intriguing Physiological Relationship

It is an unexpected but pleasant surprise when new clinical relationships are identified, and one of the most interesting is the inverse association between LDL cholesterol (LDLc) and type 2 ..... see more

Source : https://diabetes.diabetesjournals.org/content/69/10/2058