Dyslipidemia and cardiovascular disease risk among the MASHAD study population
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01204-y
Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an .....
Lipoprotein profiling in early multiple sclerosis patients: effect of chronic inflammation?
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01221-x
Inflammatory cytokines contribute to proatherogenic changes in lipid metabolism by reduction of HDL-cholesterol (HDL-C) levels, impairment of its antiinflammatory and antioxidant functions. Therefore, the protective actions of HDL-C can be .....
Genes Associated With Inflammation May Serve as Biomarkers for the Diagnosis of Coronary Artery Disease and Ischaemic Stroke - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/32164735/
The CXCL8, TNF, SOCS3 and TNFAIP3 associated with inflammation may serve as biomarkers for the diagnosis of CAD or IS. The possible mechanisms may involve the Toll-like receptor, TNF, NF-kappa .....
Simultaneous determination of five essential amino acids in plasma of Hyperlipidemic subjects by UPLC-MS/MS
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01216-8
Millions of adults have been reported with hyperlipemia in the world. It is still unclear whether the plasma level of essential amino acids (AAs) will be influenced by the hyperlipemia. .....
Carbamylated Lipoproteins and Progression of Diabetic Kidney Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/32075807/
1 Department of Medicine, University of Hong Kong, Hong Kong, China and kcbtan@hku.hk. 2 Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China. 3 Department of Medicine, .....
Statins Starve Cancer Cells to Death
Source : https://www.hopkinsmedicine.org/news/newsroom/news-releases/statins-starve-cancer-cells-to-death
"There have been epidemiological indications that people who take statins long term have fewer and less aggressive cancers, and that statins can kill cancer cells in the laboratory, but our .....
Caspase-1 as a regulatory molecule of lipid metabolism
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01220-y
Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate .....
Association between lipids and apolipoproteins on type 2 diabetes risk; moderating effects of gender and polymorphisms; the ATTICA study
Background and Aims Type 2 diabetes mellitus (T2DM) is a condition defined by hyperglycaemia, but also often presents with dyslipidaemia and suppressed HDL cholesterol. Mendelian randomization studies have suggested a .....
Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice
Source : https://onlinelibrary.wiley.com/doi/abs/10.1002/ejlt.201900443
Hyperlipidemia is a common cardiovascular disease. At present, the influence of high fat diet (HFD) on this is being explored. Recently, vegetable oils rich in omega‐3 have been reported that .....
Statins may reduce disease recurrence in patients with ulcerated primary melanoma
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.19012
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between .....
Understanding Strengths and Limitations of Different Methods of LDL-C Estimation - American College of Cardiology
Low-density lipoprotein-cholesterol (LDL-C) remains a key contributor to plaque formation and atherosclerotic cardiovascular disease (ASCVD). Measuring LDL-C by gold standard ultracentrifugation is time-intensive and expensive. As such, the Friedewald equation, .....
Hyperlipidemia and Statins Use for the Risk of New Diagnosed Sarcopenia in Patients with Chronic Kidney: A Population-Based Study
Source : https://www.mdpi.com/1660-4601/17/5/1494
Background: Previous research found that statins, in addition to its efficiency in treating hyperlipidemia, may also incur adverse drug reactions, which mainly include myopathies and abnormalities in liver function. Aim: .....
European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity in: European Journal of Endocrinology Volume 182 Issue 1 (2020)
Source : https://eje.bioscientifica.com/view/journals/eje/182/1/EJE-19-0893.xml
Obesity is an emerging condition, with a prevalence of ~20%. Although the simple measurement of BMI is likely a simplistic approach to obesity, BMI is easily calculated, and there are .....
Impact of Baseline LDL-C and Lp(a) Elevation on Coronary Revascularization in Patients with Acute Coronary Syndrome One-Year after First Percutaneous Coronary Intervention
Source : https://www.scirp.org/journal/paperinformation.aspx?paperid=98403
Objective: The aim of this study was to investigate the effect of Lipoprotein-a [Lp(a)] on Coronary Revascularizaton (CR) on one year follow up in patients with Acute Coronary Syndrome (ACS) .....
Effect of alirocumab on individuals with type 2 diabetes, high triglycerides, and low high-density lipoprotein cholesterol
Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-0991-1
Mixed dyslipidemia [elevated non-high-density lipoprotein cholesterol (non-HDL-C) and triglycerides (TGs), and decreased HDL-C] is common in type 2 diabetes mellitus (T2DM) and is associated with increased cardiovascular risk. Non-HDL-C and .....
LDL-C plays a causal role on T2DM: a Mendelian randomization analysis.
Source : https://www.ncbi.nlm.nih.gov/pubmed/32040442
Aging (Albany NY). 2020 Feb 10;12(3):2584-2594. doi: 10.18632/aging.102763. Epub 2020 Feb 10.
Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease - PubMed
1 Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada. 2 Experimental Medicine Program, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. 3 .....
Plant-based relatives of cholesterol could help gene therapy for cystic fibrosis, other diseases
PORTLAND, Ore. - Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol, new research shows. That's because the shape and structure of the phytosterols .....
The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-1191-4
It is believed that deposition of amyloid beta (Aβ) in the brain is the central pathological changes of Alzheimer's disease (AD), which triggers a series of pathological processes. However, the .....
The sensibility of the new blood lipid indicator--atherogenic index of plasma (AIP) in menopausal women with coronary artery disease
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01208-8
Dyslipidemia is a key driver of coronary artery disease (CAD) development. This study aimed to determine whether the atherogenic index of plasma (AIP), a novel comprehensive lipid index, is an .....
Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8
Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....
Association Between Non-High-Density Lipoprotein Cholesterol and Haemorrhagic Transformation in Patients With Acute Ischaemic Stroke - PubMed
1 Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, China. 2 Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue .....
Higher Bodily Adiposity, Fat Intake, and Cholesterol Serum Levels Are Associated With Higher Disease Activity in Psoriatic Arthritis Patients: Is There a Link Among Fat and Skin and Joint Involvement? - PubMed
1 Federal University of Sao Paulo (UNIFESP/ EPM). Rheumatology Division, 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, 04025-010, Brazil. leitebf@gmail.com. 2 Federal University of Sao Paulo (UNIFESP/ .....
Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8
Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....
IL-10 expression-inducing gut bacteria alleviate high-fat diet-induced obesity and hyperlipidemia in mice.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31986244
J Microbiol Biotechnol. 2020 Jan 9. doi: 10.4014/jmb.1912.12014. [Epub ahead of print]
Statins may lower mortality in high-risk prostate cancer patients
Source : https://www.eurekalert.org/pub_releases/2020-02/tju-sml021020.php
PHILADELPHIA - Among high-risk prostate cancer patients - those with high PSA and Gleason scores of 8 or more - many will develop a difficult-to-treat disease. Preliminary research suggests that .....
Association Between Obstructive Sleep Apnea and Lipid Metabolism During REM and NREM Sleep - PubMed
1 Department of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Road 600, 200233 Shanghai, China. 2 Otolaryngological Institute .....
Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1171-8
Hyperlipidemia is a common metabolic disorder and one of risk factors for cardiovascular disease. Clinical studies have shown that hyperlipidemia increases the risk of non-ischemic heart failure, while decreasing serum .....
Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744677/
The role of apolipoprotein E gene (APOE) in lipid metabolism has been well established, and APOE is associated with the risk of cardiovascular disease (CVD) and diabetes mellitus (DM). However, .....
Outcomes of Lipid Control in Secondary Prevention of Coronary Artery Disease in Finland: A 24-month Follow-Up After Acute Coronary Syndrome - PubMed
Two thirds of CAD patients with ACS and on statin therapy do not achieve LDL-C treatment target recommended by the guidelines. Since LDL-C levels fluctuate in the follow-up, a low .....
Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6
Source : https://www.tandfonline.com/doi/full/10.1080/2162402X.2019.1710063
(2020). Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6. OncoImmunology: Vol. 9, No. 1, 1710063.
The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment
Source : https://www.mdpi.com/1420-3049/25/2/271/htm
Curcumin is the main secondary metabolite of Curcuma longa and other Curcuma spp, and has been reported to have some potential in preventing and treating some physiological disorders. This study .....
HDL-cholesterol and breast cancer risk
Source : https://news.vumc.org/2020/01/23/hdl-breast-cancer-risk/
Circulating lipids have been proposed to influence the risk of breast, colorectal and other common cancers, but results from conventional epidemiologic studies have been inconsistent. Alicia Beeghly-Fadiel, PhD, Nikhil Khankari, .....
Improving cardiovascular health of the most vulnerable
Source : https://medicalxpress.com/news/2020-01-cardiovascular-health-vulnerable.html
Starting in 2016, a two-year partnership between the North Carolina Chapter of the American College of Cardiology (NCACC) and the North Carolina Association of Free and Charitable Clinics (NCAFCC) provided .....
"SULT2B1b inhibits reverse cholesterol transport and promotes cholesterol accumulation and inflammation in lymphocytes from AMI patients with low LDL-C levels. "
Source : https://www.ncbi.nlm.nih.gov/pubmed/31957803
Clin Sci (Lond). 2020 Jan 20. pii: CS20190459. doi: 10.1042/CS20190459. [Epub ahead of print]
Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD
Source : https://cjasn.asnjournals.org/content/15/1/47
Background and objectives Triglyceride-rich lipoproteins may contribute to the high cardiovascular risk of patients with CKD. This study evaluated associations of apo-B and markers of triglyceride-rich lipoproteins with cardiovascular events .....
The Underlying Mechanisms of Curcumin Inhibition of Hyperglycemia and Hyperlipidemia in Rats Fed a High-Fat Diet Combined With STZ Treatment
Source : https://www.mdpi.com/1420-3049/25/2/271/htm
Curcumin is the main secondary metabolite of Curcuma longa and other Curcuma spp, and has been reported to have some potential in preventing and treating some physiological disorders. This study .....
Hyperlipidemia affects tight junctions and pump function in the corneal endothelium.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31945314
Am J Pathol. 2020 Jan 13. pii: S0002-9440(20)30006-7. doi: 10.1016/j.ajpath.2019.11.008. [Epub ahead of print]
Effects of intensive lipid-lowering therapy on mortality after coronary bypass surgery: A meta-analysis of 7 randomised trials.
Source : https://www.ncbi.nlm.nih.gov/pubmed/31865057
BACKGROUND AND AIMS: The recent reported analysis from the ODYSSEY OUTCOMES trial showed that patients with previous coronary bypass graft surgery (CABG) had enhanced clinical benefits in response to intensive .....
Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/coa.13421
To define the impact of hyperlipidemia as a coexisting factor on the prognosis of Idiopathic Sudden Sensorineural Hearing Loss (ISSHL), we prospectively analysed the Lipid‐lowering therapy Group (LLTG) data compared .....
Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1183-4
Use of ezetimibe on top of statin therapy has been shown to be effective to reduce LDL cholesterol level in hypercholesterolemic patients. However, little is known regarding the individual variety .....
Oleic acid influences the adipogenesis of 3T3-L1 cells via DNA Methylation and may predispose to obesity and obesity-related disorders
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-019-1173-6
Adipogenesis is the process of adipocytes formation from unspecialized progenitor cells called mesenchymal stromal cells. Numerous mechanisms including epigenetic regulation modulate the correct progress of this process.