Lipid Management Connect
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Proprotein Convertase Subtilisin/Kexin Type 9: Functional Role in Lipid Metabolism and Its Therapeutic Inhibition
Peter P. Toth Part of the Contemporary Cardiology book series (CONCARD) Proprotein convertase/kexin type 9 (PCSK9) is produced and secreted by hepatocytes. Once in the extracellular milieu, PCSK9 can bind ..... see more
Source : https://link.springer.com/chapter/10.1007/978-3-030-56514-5_14
When is LDL Cholesterol Too Low?
Background: Familial hypobetalipoproteinemia (FHBL) is a rare genetic disorder that causes unusually low levels of LDL-C and apolipoprotein B (apoB). There are higher incidences of FHBL in pediatric patients with ..... see more
Source : https://unthsc-ir.tdl.org/handle/20.500.12503/30175
Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis
Background There is growing evidence that serum lipid concentrations may be associated with attempted suicide in patients with major depressive disorder (MDD), but these findings remain controversial. Thus, we performed ..... see more
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243847
Association Between the Level of Low-Density Lipoprotein Cholesterol and Coronary Atherosclerosis in Patients Who Have Undergone Coronary Computed Tomography Angiography | Inoue | Cardiology Research
Association Between the Level of Low-Density Lipoprotein Cholesterol and Coronary Atherosclerosis in Patients Who Have Undergone Coronary Computed Tomography Angiography Hiroko Inoue a, c, Yuhei Shiga b, c, Kohei Tashiro ..... see more
Source : https://www.cardiologyres.org/index.php/Cardiologyres/article/view/1180/1161
GOLIATH regulates LDLR availability and plasma LDL cholesterol levels
Increasing the availability of hepatic low-density lipoprotein receptors (LDLR) remains a major clinical target for reducing circulating plasma LDL cholesterol (LDL-C) levels. Here, we identify the molecular mechanism underlying genome-wide ..... see more
Source : https://www.biorxiv.org/content/10.1101/2020.12.09.415323v1
Effects of whey protein on glycemic control and serum lipoproteins in patients with metabolic syndrome and related conditions: a systematic review and meta-analysis of randomized controlled clinical trials
This systematic review and meta-analysis aimed to assess the effects of whey protein on serum lipoproteins and glycemic status in patients with metabolic syndrome (MetS) and related disorders. see more
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01384-7
Addressing Statin Intolerance In Practice: Moving Beyond the Controversy
Low-density lipoprotein cholesterol (LDL-C) has been shown to be atherogenic and likely have a causal relationship for the development of atherosclerotic cardiovascular disease (ASCVD). 1 Thus, reducing LDL-C levels is ..... see more
need for PCSK9 inhibitors and associated treatment costs according to the 2019 ESC dyslipidaemia guidelines vs. the risk-based allocation algorithm of the 2017 ESC consensus statement: a simulation study in a contemporary CAD cohort
The accumulation of low-density lipoprotein cholesterol (LDL-C) in the vascular wall initiates and maintains the atherosclerotic cascade. In particular for patients with prevalent atherosclerotic cardiovascular disease (ASCVD), the reduction of ..... see more
Source : https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwaa088/6017060
Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858
Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant rs1799858] and environmental [elevated serum low-density lipoprotein cholesterol (LDL-C) level] factors, ..... see more
Source : https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02639-8
The effect of calcium supplement intake on lipid profile: a systematic review and meta-analysis of randomized controlled clinical trials
Abstract Despite the potential role of dietary calcium in fat excretion, the favorable effects of calcium supplements on lipid profile remains inconclusive. The current study aimed to review the effect ..... see more
Assessment of Low LDL Cholesterol in Patients Treated by PCSK9 Inhibition: Comparison of Martin/Hopkins and Friedewald Estimations
Recent guidelines recommend further reduction of low-density lipoprotein cholesterol (LDL-C) in high-risk populations. The use of proprotein convertase subtilisin/kexin type-9 inhibitors (PCSK9i) enables many patients to achieve profound reduction in ..... see more
Source : https://link.springer.com/article/10.1007/s10557-020-07107-5
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects
Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease. Increasing evidence has shown that dyslipidemia-related cardiac damage is associated with lipid accumulation, oxidative stress, and inflammation. Thymoquinone (TQ) ..... see more
Source : https://doi.org/10.1155/2020/4878704
Maternal plasma folate concentration is positively associated with serum total cholesterol and low-density lipoprotein across the three trimesters of pregnancy
Increased first-trimester low-density lipoprotein (LDL-C) concentration has been associated with adverse pregnancy outcomes, such as gestational diabetes. The B vitamins folate, B-6, and total B-12 are key for the methyl ..... see more
Serum aromatic and branched‐chain amino acids associated with NASH demonstrate divergent associations with serum lipids
Päivi Pajukanta Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA Institute for Precision Health, School of Medicine, UCLA, ..... see more
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.14743
Emerging insights into the relationship between hyperlipidemia and the risk of diabetic retinopathy
Hyperlipidemia is correlated with a series of health problems. Notably, aside from its established role in promoting cardiovascular morbidity and mortality, hyperlipidemia has also been considered for modulating the risk ..... see more
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01415-3
Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience
Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more
Cholesterol lowering therapies and achievement of targets for primary and secondary cardiovascular prevention in type 2 diabetes: unmet needs in a large population of outpatients at specialist clinics
The well-established benefit of Low-Dense-Lipoprotein-cholesterol (LDL-c) lowering treatments (LLTs) has led clinical guidelines to lower the cardiovascular prevention targets. Despite this, there is a surprising scarcity of real-world studies (RWS) ..... see more
Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-01164-8
PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort
Background Therapeutic inhibition of PCSK9 protects against coronary artery disease (CAD) and ischemic stroke (IS). The impact on other diseases remains less well characterized. Methods We created a genetic risk ..... see more
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239752
GENetic characteristics and REsponse to lipid-lowering therapy in familial hypercholesterolemia: GENRE-FH study
Among the 146 patients enrolled in the Korean FH registry, 83 patients who had undergone appropriate LLT escalation and were followed-up for ≥ 6 months were analyzed for pathogenic variants (PVs). The ..... see more
how do I get my honoraria?
Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R-/-) Mice via Its Anti-inflammatory and Antipyroptotic Effects
Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease. Increasing evidence has shown that dyslipidemia-related cardiac damage is associated with lipid accumulation, oxidative stress, and inflammation. Thymoquinone (TQ) ..... see more
Source : https://www.hindawi.com/journals/bmri/2020/4878704/
Effect of polyphenol-rich extra-virgin olive oil on lipid profile and inflammatory biomarkers in patients undergoing coronary angiography: a randomised, controlled, clinical trial
Abstract The present study was conducted to compare the effects of high polyphenol extra-virgin olive oil (EVOO) with low polyphenol refined olive oil (ROO) on some cardiovascular risk factors in ..... see more
High-Sensitive C-reactive Protein and Atherogenic Lipid Levels in a Group of University Students with Habitual Smoking
Introduction The use of tobacco is increasing and broadly spreading throughout the world. It is a bad human behavior and is practiced by people when addicted to nicotine, which causes ..... see more
Intensive treat-to-target statin therapy and severity of diabetic retinopathy complicated by hypercholesterolaemia
To compare the effects of intensive and standard statin therapy on severity of diabetic retinopathy (DR) complicated by hypercholesterolaemia in a prespecified substudy of the standard vs. intEnsive statin therapy ..... see more
Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans
Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more
What is the role of lipids in atherosclerosis and how low should we decrease lipid levels?
Your access to the latest cardiovascular news, science, tools and resources. see more
Muscle Pain and Energy-Rich Blood: Cholesterol Medicine Affects the Organs Differently
Contrary to expectation, treatment with statins has a different effect on blood cells than on muscle cells, a new study from the University of Copenhagen reveals. Today, statins are mainly ..... see more
Clinical implications of the log linear association between LDL-C lowering and cardiovascular risk reduction: Greatest benefits when LDL-C >100 mg/dl
Background The log linear association between on-treatment LDL-C levels and ASCVD events is amplified in higher risk patient subgroups of statin versus placebo trials. Objectives Update previous systematic review to ..... see more
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240166
Could Fecal Microbiota Be a Useful Indicator of Serum Cholesterol Levels among Men?
Trepidation with blood tests among men may result in fewer routine screening and examination of their cardiovascular risk factors. Associations between fecal microbiota and serum cholesterols have not been well-established. ..... see more
Differential DNA methylation in familial hypercholesterolemia
Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more
Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease
Contribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate see more
Source : https://link.springer.com/article/10.1007/s10072-020-04791-x
Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease
Contribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate < 60 mL/min/1.73 m2) affects the association has not been investigated. ..... see more
Source : https://link.springer.com/article/10.1007/s10072-020-04791-x
Ceramides Improve Atherosclerotic Cardiovascular Disease Risk Assessment beyond Standard Risk Factors - Clin. Chim. Acta - X-MOL
Ceramides are bioactive lipids that act as secondary messengers for both intra- and inter-cellular signaling. Elevated plasma concentrations of ceramides are associated with multiple risk factors of atherosclerotic cardiovascular diseases ..... see more
Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial
Elevated baseline levels of lipoprotein(a), a genetically determined low-density lipoprotein particle, have been associated with increased risk of cardiovascular events in epidemiological studies and Mendelian randomization analyses., In keeping with ..... see more
Source : https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaa649/5922803
Time-of-day and meal size effects on clinical lipid markers
AbstractContext. Dyslipidemia and cardiovascular disease are common in shift workers and eating at night may contribute to this pathophysiology.Objective. To see more
Source : https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaa739/5922806
LDL-C/HDL-C is associated with ischaemic stroke in patients with non-valvular atrial fibrillation: a case-control study
This study explored the relationships between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in patients with non-valvular atrial fibrillation (NVAF) in Xinjiang. The ..... see more
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01392-7
Dynamic Changes of Blood Lipids in Breast Cancer Patients After (Neo)a | IJGM
Liuyue Xu, 1 Qian Dong, 2 Yaoying Long, 1 Xiaoqiong Tang, 1 Nan Zhang, 2 Kai Lu 2 1Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing ..... see more
Pre-diagnostic plasma lipid levels and the risk of amyotrophic lateral sclerosis
Abstract To assess whether pre-diagnostic lipid levels are associated with Amyotrophic lateral sclerosis (ALS) risk. Methods: We conducted a matched case-control study nested in five large prospective US cohorts (the ..... see more
Source : https://www.tandfonline.com/doi/abs/10.1080/21678421.2020.1822411
Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysis Zhang XY, Huang SH, Gong HY, Wang XY, Huang KY, Lu XF, Liu FC - Cardiol Plus
META-ANALYSIS Year : 2020 | Volume : 5 | Issue : 3 | Page : 118-129 Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic ..... see more
Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation - Clin. Biochem. - X-MOL
Lipoprotein(a) [Lp(a)] is a pro-atherogenic and pro-thrombotic LDL-like particle recognized as an independent risk factor for cardiovascular disease (CVD). The cholesterol within Lp(a) (Lp(a)-C) contributes to the reported LDL-cholesterol (LDL-C) ..... see more
Long-term prognostic utility of low-density lipoprotein (LDL) triglyceride in real-world patients with coronary artery disease and diabetes or prediabetes
Recent guidelines highlighted the association between atherosclerosis and triglyceride-enriched lipoproteins in patients with impaired glucose metabolism. However, evidence from prospective studies for long-term prognostic utility of low-density lipoprotein triglyceride (LDL-TG) ..... see more
Source : https://link.springer.com/article/10.1186/s12933-020-01125-1
YKL-40 as a novel biomarker in cardio-metabolic disorders and inflammatory diseases - PubMed
Dyslipidaemia is associated with numerous health problems that include the combination of insulin resistance, hypertension and obesity, ie, metabolic syndrome. Although the use of statins to decrease serum low density ..... see more
The Potential Role of Gut Microbiota in the Prevention and Treatment of Lipid Metabolism Disorders
Due to changes in lifestyle, diet structure, and aging worldwide, the incidence of metabolic syndromes such as hyperlipidemia, hypertension, diabetes, and obesity is increasing. Metabolic syndrome is considered to be ..... see more
LDL Cholesterol and Dysglycemia: an Intriguing Physiological Relationship
It is an unexpected but pleasant surprise when new clinical relationships are identified, and one of the most interesting is the inverse association between LDL cholesterol (LDLc) and type 2 ..... see more
Source : https://diabetes.diabetesjournals.org/content/69/10/2058