Peter P. Toth Part of the Contemporary Cardiology book series (CONCARD) Proprotein convertase/kexin type 9 (PCSK9) is produced and secreted by hepatocytes. Once in the extracellular milieu, PCSK9 can bind ..... see more
Source : https://link.springer.com/chapter/10.1007/978-3-030-56514-5_14
Background: Familial hypobetalipoproteinemia (FHBL) is a rare genetic disorder that causes unusually low levels of LDL-C and apolipoprotein B (apoB). There are higher incidences of FHBL in pediatric patients with ..... see more
Source : https://unthsc-ir.tdl.org/handle/20.500.12503/30175
Background There is growing evidence that serum lipid concentrations may be associated with attempted suicide in patients with major depressive disorder (MDD), but these findings remain controversial. Thus, we performed ..... see more
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243847
Association Between the Level of Low-Density Lipoprotein Cholesterol and Coronary Atherosclerosis in Patients Who Have Undergone Coronary Computed Tomography Angiography Hiroko Inoue a, c, Yuhei Shiga b, c, Kohei Tashiro ..... see more
Source : https://www.cardiologyres.org/index.php/Cardiologyres/article/view/1180/1161
Increasing the availability of hepatic low-density lipoprotein receptors (LDLR) remains a major clinical target for reducing circulating plasma LDL cholesterol (LDL-C) levels. Here, we identify the molecular mechanism underlying genome-wide ..... see more
Source : https://www.biorxiv.org/content/10.1101/2020.12.09.415323v1
This systematic review and meta-analysis aimed to assess the effects of whey protein on serum lipoproteins and glycemic status in patients with metabolic syndrome (MetS) and related disorders. see more
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01384-7
Low-density lipoprotein cholesterol (LDL-C) has been shown to be atherogenic and likely have a causal relationship for the development of atherosclerotic cardiovascular disease (ASCVD). 1 Thus, reducing LDL-C levels is ..... see more
The accumulation of low-density lipoprotein cholesterol (LDL-C) in the vascular wall initiates and maintains the atherosclerotic cascade. In particular for patients with prevalent atherosclerotic cardiovascular disease (ASCVD), the reduction of ..... see more
Source : https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwaa088/6017060
Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant rs1799858] and environmental [elevated serum low-density lipoprotein cholesterol (LDL-C) level] factors, ..... see more
Source : https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02639-8
Abstract Despite the potential role of dietary calcium in fat excretion, the favorable effects of calcium supplements on lipid profile remains inconclusive. The current study aimed to review the effect ..... see more
Recent guidelines recommend further reduction of low-density lipoprotein cholesterol (LDL-C) in high-risk populations. The use of proprotein convertase subtilisin/kexin type-9 inhibitors (PCSK9i) enables many patients to achieve profound reduction in ..... see more
Source : https://link.springer.com/article/10.1007/s10557-020-07107-5
Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease. Increasing evidence has shown that dyslipidemia-related cardiac damage is associated with lipid accumulation, oxidative stress, and inflammation. Thymoquinone (TQ) ..... see more
Source : https://doi.org/10.1155/2020/4878704
Increased first-trimester low-density lipoprotein (LDL-C) concentration has been associated with adverse pregnancy outcomes, such as gestational diabetes. The B vitamins folate, B-6, and total B-12 are key for the methyl ..... see more
Päivi Pajukanta Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA Institute for Precision Health, School of Medicine, UCLA, ..... see more
Source : https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.14743
Hyperlipidemia is correlated with a series of health problems. Notably, aside from its established role in promoting cardiovascular morbidity and mortality, hyperlipidemia has also been considered for modulating the risk ..... see more
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01415-3
Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more
The well-established benefit of Low-Dense-Lipoprotein-cholesterol (LDL-c) lowering treatments (LLTs) has led clinical guidelines to lower the cardiovascular prevention targets. Despite this, there is a surprising scarcity of real-world studies (RWS) ..... see more
Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-01164-8
Background Therapeutic inhibition of PCSK9 protects against coronary artery disease (CAD) and ischemic stroke (IS). The impact on other diseases remains less well characterized. Methods We created a genetic risk ..... see more
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239752
Among the 146 patients enrolled in the Korean FH registry, 83 patients who had undergone appropriate LLT escalation and were followed-up for ≥ 6 months were analyzed for pathogenic variants (PVs). The ..... see more
Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease. Increasing evidence has shown that dyslipidemia-related cardiac damage is associated with lipid accumulation, oxidative stress, and inflammation. Thymoquinone (TQ) ..... see more
Source : https://www.hindawi.com/journals/bmri/2020/4878704/
Abstract The present study was conducted to compare the effects of high polyphenol extra-virgin olive oil (EVOO) with low polyphenol refined olive oil (ROO) on some cardiovascular risk factors in ..... see more
Introduction The use of tobacco is increasing and broadly spreading throughout the world. It is a bad human behavior and is practiced by people when addicted to nicotine, which causes ..... see more
To compare the effects of intensive and standard statin therapy on severity of diabetic retinopathy (DR) complicated by hypercholesterolaemia in a prespecified substudy of the standard vs. intEnsive statin therapy ..... see more
Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more
Your access to the latest cardiovascular news, science, tools and resources. see more
Contrary to expectation, treatment with statins has a different effect on blood cells than on muscle cells, a new study from the University of Copenhagen reveals. Today, statins are mainly ..... see more
Background The log linear association between on-treatment LDL-C levels and ASCVD events is amplified in higher risk patient subgroups of statin versus placebo trials. Objectives Update previous systematic review to ..... see more
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240166
Trepidation with blood tests among men may result in fewer routine screening and examination of their cardiovascular risk factors. Associations between fecal microbiota and serum cholesterols have not been well-established. ..... see more
Your access to the NCBI website at www.ncbi.nlm.nih.gov has been temporarily blocked due to a possible misuse/abuse situation involving your site. This is not an indication of a security issue ..... see more
Contribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate see more
Source : https://link.springer.com/article/10.1007/s10072-020-04791-x
Contribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate < 60 mL/min/1.73 m2) affects the association has not been investigated. ..... see more
Source : https://link.springer.com/article/10.1007/s10072-020-04791-x
Ceramides are bioactive lipids that act as secondary messengers for both intra- and inter-cellular signaling. Elevated plasma concentrations of ceramides are associated with multiple risk factors of atherosclerotic cardiovascular diseases ..... see more
Elevated baseline levels of lipoprotein(a), a genetically determined low-density lipoprotein particle, have been associated with increased risk of cardiovascular events in epidemiological studies and Mendelian randomization analyses., In keeping with ..... see more
Source : https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaa649/5922803
AbstractContext. Dyslipidemia and cardiovascular disease are common in shift workers and eating at night may contribute to this pathophysiology.Objective. To see more
Source : https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaa739/5922806
This study explored the relationships between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and other clinical indicators and ischaemic stroke (IS) in patients with non-valvular atrial fibrillation (NVAF) in Xinjiang. The ..... see more
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01392-7
Liuyue Xu, 1 Qian Dong, 2 Yaoying Long, 1 Xiaoqiong Tang, 1 Nan Zhang, 2 Kai Lu 2 1Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing ..... see more
Abstract To assess whether pre-diagnostic lipid levels are associated with Amyotrophic lateral sclerosis (ALS) risk. Methods: We conducted a matched case-control study nested in five large prospective US cohorts (the ..... see more
Source : https://www.tandfonline.com/doi/abs/10.1080/21678421.2020.1822411
META-ANALYSIS Year : 2020 | Volume : 5 | Issue : 3 | Page : 118-129 Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic ..... see more
Lipoprotein(a) [Lp(a)] is a pro-atherogenic and pro-thrombotic LDL-like particle recognized as an independent risk factor for cardiovascular disease (CVD). The cholesterol within Lp(a) (Lp(a)-C) contributes to the reported LDL-cholesterol (LDL-C) ..... see more
Recent guidelines highlighted the association between atherosclerosis and triglyceride-enriched lipoproteins in patients with impaired glucose metabolism. However, evidence from prospective studies for long-term prognostic utility of low-density lipoprotein triglyceride (LDL-TG) ..... see more
Source : https://link.springer.com/article/10.1186/s12933-020-01125-1
Dyslipidaemia is associated with numerous health problems that include the combination of insulin resistance, hypertension and obesity, ie, metabolic syndrome. Although the use of statins to decrease serum low density ..... see more
Due to changes in lifestyle, diet structure, and aging worldwide, the incidence of metabolic syndromes such as hyperlipidemia, hypertension, diabetes, and obesity is increasing. Metabolic syndrome is considered to be ..... see more
It is an unexpected but pleasant surprise when new clinical relationships are identified, and one of the most interesting is the inverse association between LDL cholesterol (LDLc) and type 2 ..... see more
Source : https://diabetes.diabetesjournals.org/content/69/10/2058