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A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01236-4

Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases. Particularly in ischemic stroke (IS), the abnormal expression of MALAT1 played important roles including promotion of angiogenesis, inhibition of apoptosis and inflammation and regulation of autophagy. However, the effects of genetic variation (single nucleotide polymorphisms, SNPs) of MALAT1 on IS have rarely been explored.