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GOLIATH regulates LDLR availability and plasma LDL cholesterol levels

GOLIATH regulates LDLR availability and plasma LDL cholesterol levels

Source :

https://www.biorxiv.org/content/10.1101/2020.12.09.415323v1

Increasing the availability of hepatic low-density lipoprotein receptors (LDLR) remains a major clinical target for reducing circulating plasma LDL cholesterol (LDL-C) levels. Here, we identify the molecular mechanism underlying genome-wide significant associations in the GOLIATH locus with plasma LDL-C levels.