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Elevated Lipids are Associated with Reduced Regional Brain Structure in Youth with Bipolar Disorder.

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Objective Abnormal blood lipid levels are common in bipolar disorder (BD) and correlate with mood symptoms and neurocognition. However, studies have not examined the lipid-brain structure association in BD or youth. Methods This study examined low-density-lipoprotein (LDL-C), high-density-lipoprotein (HDL-C), triglycerides, and total cholesterol (TC) levels in relation to brain structure utilizing T1-weighted images, amongst participants ages 13-20 with BD (n=55) and healthy controls (HC; n=47).