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Transcatheter aortic valve replacement in patients undergoing robotic totally endoscopic coronary artery bypass: A case series

Transcatheter aortic valve replacement (TAVR) has been utilized to treat patients with symptomatic aortic stenosis (AS). Recent trials suggest comparable efficacy compared to surgical aortic valve replacement (SAVR). Robotic off-pump ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510675/


Conclusion/Relevance: Since patients with severe aortic stenosis are at high risk of developing cardiac arrest and cardiogenic shock upon induction of anesthesia, the ability to treat severe symptomatic AS with TAVR under conscious sedation prior to TECAB can be considered as a safe an effective treatment.

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  • October 03, 2022
    Key Points • Source: Frontiers in Cardiovascular Medicine • Conclusion/Relevance: “The case series demonstrates a hybrid approach that offers complete sternotomy sparing cardiovascular care to treat severe symptomatic AS and CAD. Since patients with Show More
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Influence of center surgical aortic valve volume on outcomes of transcatheter aortic valve replacement

Matthew Gandjian, MD, a Arjun Verma, a Zachary Tran, MD, a Yas Sanaiha, MD, a Peter Downey, MD, a Richard J. Shemin, MD, a, b and Peyman Benharash, MD a, ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9510825/


Conclusions: SAVR experience is associated with improved TAVR outcomes in a modern cohort. Our findings suggest the need for continued collaboration between cardiologists and surgeons to maximize patient safety.

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Aortic valve calcium volume as measured by native versus contrast-enhanced computer tomography and the implications for the diagnosis of severe aortic stenosis in TAVR patients with low-gradient aortic stenosis - The Egyptian Heart Journal

Background Most of TAVR centers evaluate the calcium score in contrast-enhanced (ce) CT. We compared in this study between different methodologies to measure calcium score. We studied also the difference ..... see more

Source : https://tehj.springeropen.com/articles/10.1186/s43044-022-00311-8


Conclusions: Conclusions: The diagnosis of severe LGAS should not depend on a single parameter as calcium score. In these patients, calcium score should be measured in nc CT and not in ce CT.

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Investigation on Imaging Features and Clinical Significance of Cardiac CT in Comprehensive Evaluation of Aortic Valve and Root before Percutaneous Aortic Valve Replacement

Medical imaging feature analysis is the basis of medical image processing and analysis. The solution of this problem not only directly affects the successful application of computer graphics and image ..... see more

Source : https://www.hindawi.com/journals/bmri/2022/5838670/



Conclusions: Through the comprehensive evaluation of the aortic valve and root before aortic valve replacement, the analysis of imaging characteristics, and the discussion of clinical significance, compared with the traditional median thoracotomy approach, it is safe and effective. It can reduce the surgical incision and reduce the...

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Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure - PubMed

The comprehension of the pathophysiological mechanisms, the identification of druggable targets, and putative biomarkers for aortic valve stenosis can be pursued through holistic approaches such as proteomics. However, tissue homogenization ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36136308/


Relevance: The comprehension of the pathophysiological mechanisms, the identification of druggable targets, and putative biomarkers for aortic valve stenosis can be pursued through holistic approaches such as proteomics. However, tissue homogenization and protein extraction are made difficult by tissue calcification. The reproducibility of...

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Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters

BackgroundStudies suggest that performing an electrophysiological study (EPS) may be useful to identify patients with new-onset left bundle branch block (LBBB) post-TAVR at risk of atrioventricular block. However, tools to ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fcvm.2022.910693/full


Conclusions: PR interval assessment may be useful to select patients with new-onset LBBB after TAVR who may benefit most from an EPS. In patients with PR ≤ 200 ms and ΔPR < 20 ms the likelihood of abnormal EPS is very low independently of QRS changes.

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Procedural Outcomes of a Self-Expanding Transcatheter Heart Valve in Small Annuli - PubMed

The ACURATE neo/neo2 S subgroup shows a convincing hemodynamic outcome according to low mean gradient even outside the previous IFUs without a relevant increase in the rate of PVL or ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36142960/


Conclusions: The ACURATE neo/neo2 S subgroup shows a convincing hemodynamic outcome according to low mean gradient even outside the previous IFUs without a relevant increase in the rate of PVL or PPM. In addition to known factors such as annulus area and BMI, potential predictors for PPM are severe annulus calcification and implantation depth....

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Role of endothelial CXCR4 in the development of aortic valve stenosis

BackgroundCXCL12/CXCR4 signaling is essential in cardiac development and repair, however, its contribution to aortic valve stenosis (AVS) remains unclear. In this study, we tested the role of endothelial CXCR4 on ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fcvm.2022.971321/full



Conclusions: The data collected throughout this study suggest the deletion of CXCR4 in endothelial cells is linked to the development of aortic valve stenosis and left ventricular hypertrophy. The statistically significant parameters measured indicate that endothelial cell CXCR4 plays an important role in aortic valve development and...

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Sex Disparities in the Treatment of Aortic Stenosis and Related Outcomes: An Analysis of the National Inpatient Sample - PubMed

Introduction The impact of transcatheter aortic valve replacement (TAVR) on sex disparities has not been well established. This study sought to examine the impact of sex on outcomes following aortic ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36103808/


Conclusion/Relevance: TAVR is associated with a lower in-hospital mortality in women compared to SAVR. Thus, TAVR may represent a potential intervention to narrow the sex-based disparities in the management of AS.

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Concomitant anaortic OPCAB and transfemoral TAVR for high-risk patients: A case series - PubMed

Combined anaortic OPCAB and transfemoral TAVR is a safe and feasible approach to treating concomitant extensive coronary artery disease and severe aortic stenosis. The aortic no-touch technique provides benefits in ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36098378/


Conclusions: Combined anaortic OPCAB and transfemoral TAVR is a safe and feasible approach to treating concomitant extensive coronary artery disease and severe aortic stenosis. The aortic no-touch technique provides benefits in the elderly high-risk patients by reducing the risk of postoperative myocardial infarction and cerebrovascular stroke.

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Management of Failed Bioprosthetic Aortic Valves: Mitigating Complications and Optimizing Outcomes

Management of Failed Bioprosthetic Aortic Valves: Mitigating Complications and Optimizing Outcomes: The use of bioprosthetic prostheses during surgical aortic valve replacements has increased dramatically over the last two decades, accounting ..... see more

Source : https://www.hindawi.com/journals/jitc/2022/9737245/


Conclusions: Due to the increase in bioprosthetic valve utilization for the treatment of aortic valve disease and patients with longer life expectancy, bioprosthetic valve failure is becoming a significant problem requiring innovative treatment strategies. Redo-SAVR has traditionally been the only treatment modality for failed biologic valves,...

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A Pilot Study to Assess the Clinical Onset of IV Heparin in Interventional Cardiology and Cardiac Surgery

To determine the onset of heparin anticoagulation, using 2 different measures of activated clotting times (ACT), thromboelastography (TEG; R-time), and anti-Xa levels, after administering low- (100 U/kg) and high- (300 ..... see more

Source : https://www.jcvaonline.com/article/S1053-0770(22)00546-8/fulltext


Conclusions: In this pilot study, heparin anticoagulation was detected as early as 30 seconds after IV administration, based on ACT, anti-Xa levels, and TEG R-time.



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A rare delayed complication after TAVR: Acute severe aortic insufficiency - PubMed

Transcatheter aortic valve replacement (TAVR) has become the standard of care for managing severe aortic stenosis (AS) in high surgical risk patients. Despite favorable outcomes, TAVR has been associated with ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36073090/


Conclusion/Relevance: Herein, we describe a unique and atypical case of a patient who presented with heart failure and was found to have severe AR in the context of having had TAVR 5 years prior using an Evolut R prosthetic valve.

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Outcomes of transcatheter aortic valve replacement at teaching versus nonteaching hospitals - PubMed

With the evolution and expansion of TAVR to nonteaching centers, mortality, and readmission rates are not significantly different between nonteaching and teaching hospitals. Higher unadjusted in-hospital mortality at teaching centers ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36073067/


Conclusion: With the evolution and expansion of TAVR to nonteaching centers, mortality, and readmission rates are not significantly different between nonteaching and teaching hospitals. Higher unadjusted in-hospital mortality at teaching centers suggest these centers more often treat high risk patients with associated increased complications.

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Validation of reliability and predictivity of membrane septum length measurements for pacemaker need after transcatheter aortic valve replacement - PubMed

External validity and predictive accuracy of MS length for PMI after TAVR were not sufficient to provide better risk stratification over the established predictors in our cohort. Moreover, the ID ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36073020/


Conclusions: External validity and predictive accuracy of MS length for PMI after TAVR were not sufficient to provide better risk stratification over the established predictors in our cohort. Moreover, the ID and ΔMSID, but not MS length alone, are predictive of future PMI after TAVR.

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Advances in technology and techniques for transcatheter aortic valve replacement with concomitant peripheral arterial disease

Aortic stenosis (AS) is a prevalent disease affecting 3.7% of the adult population aged 65 or above. In the past, surgical aortic valve replacement (SAVR) was the only definitive therapy ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fmedt.2022.959249/full


Relevance:In this review, the prevalence and outcome of TAVR patients with PAD will be discussed. Furthermore, novel technologies and techniques that enable TAVR to be safely performed using transfemoral or alternative access in patients with severe PAD will be reviewed.



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Structural analysis of regional transcatheter aortic valve underexpansion and its implications for subclinical leaflet thrombosis - PubMed

doi: 10.1002/cnm.3641. Online ahead of print. 1 The DU Cardiovascular Biomechanics Laboratory, Department of Mechanical and Materials Engineering, University of Denver, Denver, Colorado, USA. doi: 10.1002/cnm.3641. Online ahead of print. ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/36054800/


Conclusion/Relevance: The study improves our understanding of the effects of regional stent under-expansion in TAVR. Post-procedural balloon dilatation of self-expanding TAVs can potentially be advantageous in reducing leaflet distortion and normalizing leaflet stress distribution. Large-scale, prospective, and well-controlled studies are...

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Valve-in-valve TAVR using BASILICA technique and cerebral protection in a patient with severe dysfunction of the aortic bioprosthesis

Transcatheter aortic valve replacement (TAVR) is recommended for high- and intermediate-risk patients with severe aortic stenosis and a suitable option for degenerated surgical bioprosthetic valves. The feasibility of a complete ..... see more

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9421518/


Conclusion/Relevance: BASILICA is a novel transcatheter electrosurgical technique which increases the safety of ViV TAVR, but also enhances the risk of stroke [3]. Thus, the use of a cerebral protection device (CPD) has been advocated when performing BASILICA prior to TAVR

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Temporal Trends in Internal vs. External Referrals for TAVR in a Large Academic Center: Patients Characteristics and Outcomes

Background . Since transcatheter aortic valve replacement (TAVR) first became approved for inoperable patients followed by high, intermediate-, and low-risk patients, referrals to TAVR centers have rapidly increased. The purpose ..... see more

Source : https://www.hindawi.com/journals/jitc/2022/6074368/


Conclusions: This study presents the referral pattern to a large TAVR center in North Carolina. Over time, there was an increase in external referrals suggesting that TAVR is increasingly adopted as an important component of the management of aortic valve stenosis. Internally and externally referred patients have differences in baseline...