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Defining the Phenotypes for Heart Failure With Preserved Ejection Fraction - Current Heart Failure Reports

Defining the Phenotypes for Heart Failure With Preserved Ejection Fraction - Current Heart Failure Reports

Source : https://link.springer.com/article/10.1007/s11897-022-00582-x

Purpose of Review Heart failure with preserved ejection fraction (HFpEF) imposes a significant burden on society and healthcare. The lack in efficacious therapies is likely due to the significant heterogeneity of HFpEF. In this review, we define various phenotypes based on underlying comorbidities or etiologies, discuss phenotypes arrived at by novel methods, and explore therapeutic targets.


Summary: We synthesized the literature and propose three broad phenotypes: (1) young, with few comorbidities, usually obese and with low natriuretic peptide levels, (2) obese with substantive cardiometabolic burden and comorbidities and impaired ventricular relaxation, (3) old, multimorbid, with high rates of atrial fibrillation, renal and coronary artery disease, chronic obstructive pulmonary disease, and left ventricular hypertrophy. We also propose potential therapeutic strategies for these phenotypes.