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The role of inflammation and the possibilities of inflammation reduction to prevent cardiovascular events - PubMed

Chronic systemic inflammation is a risk factor for cardiovascular (CV) disease (CVD). Whether this relationship extends to subclinical inflammation, quantified by values of circulating markers associated with inflammation in the ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35919577/



Relevance: Chronic systemic inflammation is a risk factor for cardiovascular (CV) disease (CVD). Whether this relationship extends to subclinical inflammation, quantified by values of circulating markers associated with inflammation in the high range of the normal interval, remains debatable. This narrative review evaluates evidence exploring...

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Conclusions: During the study period from 2015 to 2018, 30‐day HF readmissions after TAVR remained steady despite all‐cause readmissions decreasing significantly. All‐cause readmission mortality and HF readmission mortality also showed a nonsignificant downtrend. HF readmissions were comparable across low‐, medium‐, and...

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Conclusions: A large percentage of patients receiving BA achieved LDL‐C reductions comparable to a moderate‐ or high‐intensity statin. Factors including statin absence, female sex, diabetes history, ezetimibe use, and a higher high‐sensitivity C‐reactive protein level may be useful to identify patients who may have a greater LDL‐C...

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New, Novel Lipid-Lowering Agents for Reducing Cardiovascular Risk: Beyond Statins

Angiopoietin-like 3 (ANGPTL3), angiopoietin-like 4 (ANGPTL4), and angiopoietin-like 8 (ANGPTL8) inhibit LPL activity in a coordinated fashion, thereby regulating the plasma TG levels. ANGPTL3 and ANGPTL8 are produced and secreted ..... see more

Source : https://www.e-dmj.org/journal/view.php?doi=10.4093/dmj.2022.0198



Conclusion/Relevance: During the past decade, several drugs have been developed for the treatment of dyslipidemia. Inclisiran, a small interfering RNA that targets proprotein convertase subtilisin/kexin type 9 (PCSK9), shows comparable effects to that of PCSK9 monoclonal antibodies. Bempedoic acid, an ATP citrate lyase inhibitor, is a...

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New Therapeutic Approaches in Treatment of Dyslipidaemia-A Narrative Review - PubMed

Dyslipidaemia is a well-known risk factor for the development of cardiovascular disease, a leading cause of morbidity and mortality in developed countries. As a consequence, the medical community has been ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35890138/



Conclusion: This article provides a short summary of new agents currently used or being developed for lipid lowering treatment.


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Bempedoic Acid: for Whom and When - Current Atherosclerosis Reports

Purpose of Review The aim of creating an orally active non-statin cholesterol-lowering drug was achieved with bempedoic acid, a small linear molecule providing both a significant low-density lipoprotein cholesterol (LDL-C) ..... see more

Source : https://link.springer.com/article/10.1007/s11883-022-01054-2



Summary: The extensive knowledge on bempedoic acid mechanism, metabolism and side effects has led to an improved understanding of the potential benefits of this agent and offers a possible alternative to cardiologists and clinical practitioners somewhat worn out today by the occurrence of the muscular side effects of statins.

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Early Discovery of Children With Lysosomal Acid Lipase Deficiency With the Universal Familial Hypercholesterolemia Screening Program

Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive lysosomal storage disorder, caused by homozygous or compound heterozygous pathogenic variants in the LIPA gene. Clinically, LAL-D is under- and misdiagnosed, ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fgene.2022.936121/full



Relevance: Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive lysosomal storage disorder, caused by homozygous or compound heterozygous pathogenic variants in the LIPA gene. Clinically, LAL-D is under- and misdiagnosed, due to similar clinical and laboratory findings with other cholesterol or liver misfunctions. As a part of...

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Clinical Aspects of Genetic and Non-Genetic Cardiovascular Risk Factors in Familial Hypercholesterolemia - PubMed

1 Division of Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary. 2 Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35885941/



Conclusion: In this review, we summarize the most important genetic and non-genetic factors that might affect the risk prediction and therapeutic strategy in FH through the eyes of clinicians focusing on disorders that might not be in the center of FH research. The review highlights the complexity of FH care and the need of an...

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Identification of protective biologic factors in patients with high cardiovascular risk, but normal coronary arteries (NormCorn) - PubMed

Patients with a high risk for CAD, but normal coronary arteries have EPCs function and telomere length which resemble healthy volunteers, and augmented compared with patients with established CAD, which ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35866511/


Conclusion: Patients with a high risk for CAD, but normal coronary arteries have EPCs function and telomere length which resemble healthy volunteers, and augmented compared with patients with established CAD, which could serve as a protective mechanism against atherosclerosis development in these high-risk patients.

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Prediction performance and fairness heterogeneity in cardiovascular risk models - Scientific Reports

Prediction models are commonly used to estimate risk for cardiovascular diseases, to inform diagnosis and management. However, performance may vary substantially across relevant subgroups of the population. Here we investigated ..... see more

Source : https://www.nature.com/articles/s41598-022-16615-3



Conclusion/Relevance: Our findings highlight the need to characterize and quantify the behavior of clinical risk models within specific subpopulations so they can be used appropriately to facilitate more accurate, consistent, and equitable assessment of disease risk.

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Prediction performance and fairness heterogeneity in cardiovascular risk models - Scientific Reports

Prediction models are commonly used to estimate risk for cardiovascular diseases, to inform diagnosis and management. However, performance may vary substantially across relevant subgroups of the population. Here we investigated ..... see more

Source : https://www.nature.com/articles/s41598-022-16615-3

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The associations between TMAO-related metabolites and blood lipids and the potential impact of rosuvastatin therapy - Lipids in Health and Disease

Background Trimethylamine N-oxide (TMAO)-related metabolites are associated with the pathogenesis of atherosclerotic cardiovascular disease (ASCVD) and are known to disrupt lipid metabolism. The aims of this study were to evaluate ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-022-01673-3



Relevance: The evidence about the association of the essential trace element (ETE) mixture with atherosclerotic cardiovascular disease (ASCVD) amongst older adults is limited. This study aims to evaluate the associations of single ETEs and the ETE mixture with the 10-year ASCVD risks and its predicting factors in Chinese community-dwelling...

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The association between essential trace element mixture and atherosclerotic cardiovascular disease risk among Chinese community-dwelling older adults - Environmental Science and Pollution Research

The evidence about the association of the essential trace element (ETE) mixture with atherosclerotic cardiovascular disease (ASCVD) amongst older adults is limited. This study aims to evaluate the associations of ..... see more

Source : https://link.springer.com/article/10.1007/s11356-022-22066-0



Relevance: The evidence about the association of the essential trace element (ETE) mixture with atherosclerotic cardiovascular disease (ASCVD) amongst older adults is limited. This study aims to evaluate the associations of single ETEs and the ETE mixture with the 10-year ASCVD risks and its predicting factors in Chinese community-dwelling...

ROXANNE SINGER-GHEORGHIU from Generation NP, Ramzy Rimawi from Doctor Unite Commented on a Post
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Non-Statin LDL-C Treatment Options

Up to 30% of patients prescribed treatment to lower LDL-C are intolerant of statins and discontinue taking them1,2. Additionally, a large segment of the LDL-C population is not at treatment goal3. These patients require additional non-statin therapy or an entirely non-statin alternative.

When considering a non-statin therapy for your patients, whether as add-on or replacement, how important are each of the following traits: oral vs. injectable product, effect on CRP, low risk of new incident diabetes? European and US guidelines differ as do AHA/ACC and AACE/ACE; which guidelines do you follow and why?

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  • from Generation NP July 22, 2022
    What about very high calcium scoring test? Ideas
  • from Doctor Unite July 01, 2022
    Because of the importance of statins, it is not very often that we consider non-statin therapies if a patient is high risk. However, when a non-statin is chosen, oral agents Show More

Harmonisation of large-scale, heterogeneous individual participant adverse event data from randomised trials of statin therapy - PubMed

In this meta-analysis of adverse event data from the large randomised trials of statins, approaches based on common standards for data organisation and classification have provided a resource capable of ..... see more

Source : https://pubmed.ncbi.nlm.nih.gov/35815805/



Conclusion: In this meta-analysis of adverse event data from the large randomised trials of statins, approaches based on common standards for data organisation and classification have provided a resource capable of allowing reliable and rapid evaluation of any previously unknown benefits or hazards of statin therapy.

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  • July 19, 2022
    Key Points • Source: Clinical Trials • Conclusion: “In this meta-analysis of adverse event data from the large randomised trials of statins, approaches based on common standards for data organisation and classification have provided Show More
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Regulatory Non-Coding RNAs in Familial Hypercholesterolemia, Theranostic Applications

Familial hypercholesterolemia (FH) is a common monogenic disease which is associated with high serum levels of low-density lipoprotein cholesterol (LDL-C) and leads to atherosclerosis and cardiovascular disease (CVD). Early diagnosis ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fcell.2022.894800/full



Relevance: In this review, we briefly discussed the mechanisms and pathophysiology of FH and novel therapeutic strategies for the treatment of FH. Moreover, the theranostic effects of different non-coding RNAs for the treatment and diagnosis of FH were highlighted. Finally, the advantages and disadvantages of ncRNA-based therapies vs....

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Familial Hypercholesterolemia

Familial hypercholesterolemia (FH) is characterized by significantly elevated low-density lipoprotein cholesterol (LDL-C) that leads to atherosclerotic plaque deposition in the coronary arteries and proximal aorta at an early age and ..... see more

Source : https://www.ncbi.nlm.nih.gov/books/NBK174884/



Relevance: Familial hypercholesterolemia (FH) is characterized by significantly elevated low-density lipoprotein cholesterol (LDL-C) that leads to atherosclerotic plaque deposition in the coronary arteries and proximal aorta at an early age and increases the risk of premature cardiovascular events such as angina and myocardial infarction;...

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The Progression of Treatment for Refractory Hypercholesterolemia: Focus on the Prospect of Gene Therapy

Refractory hypercholesterolemia (RH), including homozygous familial hypercholesterolemia (HoFH) and compound heterozygous familial hypercholesterolemia, is characterized by high levels of low-density lipoprotein cholesterol (LDL-C) despite existing cholesterol-lowering methods at maximal tolerable ..... see more

Source : https://www.frontiersin.org/articles/10.3389/fgene.2022.911429/full



Relevance: Currently, new cholesterol-lowering strategies are on the market, not only at the protein level [i.e., bempedoic acid (inhibiting ATP-citrate lyase), alirocumab and evolocumab (monoclonal antibodies against PCSK9), evinacumab (monoclonal antibody against ANGPTL3)] but also at the transcript level [i.e., mipomersen (antisense...

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Long-term cancer risk in heterozygous familial hypercholesterolemia relatives: a 25-year cohort study - Lipids in Health and Disease

Background Heterozygous familial hypercholesterolemia (HeFH) due to low-density lipoprotein receptor (LDLR) mutations predisposes patients to highly elevated levels of cholesterol, and patients are at increased risk of adverse cardiovascular events ..... see more

Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-022-01666-2



Conclusion: In Denmark, LDLR mutation-carrying HeFH relatives did not have a different cancer risk than the general population. In contrast, nonmutation-carrying relatives had a lower risk of cancer.