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Long-term cancer risk in heterozygous familial hypercholesterolemia relatives: a 25-year cohort study - Lipids in Health and Disease

Long-term cancer risk in heterozygous familial hypercholesterolemia relatives: a 25-year cohort study - Lipids in Health and Disease

Source :

https://lipidworld.biomedcentral.com/articles/10.1186/s12944-022-01666-2

Background Heterozygous familial hypercholesterolemia (HeFH) due to low-density lipoprotein receptor (LDLR) mutations predisposes patients to highly elevated levels of cholesterol, and patients are at increased risk of adverse cardiovascular events and other morbidities. Whether the LDLR mutation and high cholesterol levels affect the risk of cancer remains unknown.



Conclusion: In Denmark, LDLR mutation-carrying HeFH relatives did not have a different cancer risk than the general population. In contrast, nonmutation-carrying relatives had a lower risk of cancer.