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The associations between TMAO-related metabolites and blood lipids and the potential impact of rosuvastatin therapy - Lipids in Health and Disease

The associations between TMAO-related metabolites and blood lipids and the potential impact of rosuvastatin therapy - Lipids in Health and Disease

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944-022-01673-3

Background Trimethylamine N-oxide (TMAO)-related metabolites are associated with the pathogenesis of atherosclerotic cardiovascular disease (ASCVD) and are known to disrupt lipid metabolism. The aims of this study were to evaluate the associations between TMAO-related metabolites and blood lipids and determine how lowering the lipid profile via rosuvastatin therapy influences TMAO-related metabolites.



Relevance: The evidence about the association of the essential trace element (ETE) mixture with atherosclerotic cardiovascular disease (ASCVD) amongst older adults is limited. This study aims to evaluate the associations of single ETEs and the ETE mixture with the 10-year ASCVD risks and its predicting factors in Chinese community-dwelling older adults.