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Nonproteolytic Intracellular Domain of MT1-MMP (Membrane-Type 1 Matrix Metalloproteinase) Coordinately Modulates Abdominal Aortic Aneurysm and Atherosclerosis to Mice - PubMed

Nonproteolytic Intracellular Domain of MT1-MMP (Membrane-Type 1 Matrix Metalloproteinase) Coordinately Modulates Abdominal Aortic Aneurysm and Atherosclerosis to Mice - PubMed

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https://pubmed.ncbi.nlm.nih.gov/36073351/

Our findings show that the cytoplasmic domain of MT1-MMP safeguards from AAA and atherosclerotic plaque development through a proteolysis-independent signaling mechanism associated with Netrin-1 expression. This unexpected function of MT1-MMP unveils a novel mechanism of synchronous onset of AAA and ...


Conclusions: Our findings show that the cytoplasmic domain of MT1-MMP safeguards from AAA and atherosclerotic plaque development through a proteolysis-independent signaling mechanism associated with Netrin-1 expression. This unexpected function of MT1-MMP unveils a novel mechanism of synchronous onset of AAA and atherogenesis and highlights its importance in the control of vascular wall homeostasis.