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Clinical features and genetic analysis of a Brazilian patient with sitosterolemia: a case report - PubMed

Clinical features and genetic analysis of a Brazilian patient with sitosterolemia: a case report - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/40532043/

Sitosterolemia is a rare genetic lipid disorder caused by mutations in the ABCG5/ABCG8, genes. It is characterized by plasmatic plant sterols accumulation, formation of tendon and tuberous xanthomas and early...

Brazilian man with early xanthomas, thrombocytopenia, and premature MI was diagnosed with sitosterolemia due to homozygous ABCG8 mutation; dietary plant-sterol restriction plus ezetimibe led to marked clinical improvement.

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AHA Scientific Sessions 2025: Transformative advances in cardiovascular care

Dr. Joanna Chikwui, Chief of Cardiac Surgery at Cedars-Sinai and Chair of AHA Scientific Sessions, spotlighted significant breakthroughs across cardiology. Updates included novel therapies for hyperlipidemia, gene-editing tools for inherited cardiovascular risk, innovations in atrial fibrillation management, and compelling lifestyle findings—including a surprising inverse relationship between moderate coffee intake and AF incidence.

Dr. Heidi May, Epidemiologist at Intermountain Health, presented results from the Target-D randomized trial, which found that personalized vitamin D dosing after myocardial infarction significantly reduced the risk of recurrent heart attack. These findings underscore the importance of individualized supplementation strategies and signal a broader shift toward precision prevention and risk stratification in cardiovascular care.

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Use of intravenous lipid emulsions in drug-induced toxicities: a 2025 narrative review - PubMed

Use of intravenous lipid emulsions in drug-induced toxicities: a 2025 narrative review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41247632/

Intravenous lipid emulsions (ILE) were first proposed in 1998 as a treatment for bupivacaine-induced cardiac arrest. Since then, their use has expanded to include poisonings by various lipophilic drugs such...

ILEs treat lipophilic drug toxicities through lipid sink, shuttle, and cardiotonic mechanisms; benefits shown in select poisonings, but mortality impact, optimal dosing, and indications remain uncertain, requiring higher-quality evidence.

 

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Managing diabetes in pregnancy requires a dual approach: lifestyle changes like diet and exercise, plus targeted drug therapy with insulin or antihyperglycemics. Early action, patient education, and tools like CGM and telemedicine enhance glycemic control and outcomes.

Explore strategies for safer diabetic pregnancies

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