Optimal Management of Chronic Severe Aortic Regurgitation ― How to Determine Cutoff Values for Surgical Intervention? ―
Source : https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-21-0652/_html/-char/en
Aortic regurgitation (AR) is a common valvular heart disease, but the optimal timing of surgical intervention remains controversial. In the natural history of chronic severe AR, sudden death is rare,...
Impaction of regurgitation jet on anterior mitral leaflet is associated with diastolic dysfunction in patients with bicuspid aortic valve and mild insufficiency: a cardiovascular magnetic resonance study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34448067/
To assess the impact of regurgitant jet direction on left ventricular function and intraventricular hemodynamics in asymptomatic patients with bicuspid aortic valve (BAV) and mild aortic valve regurgitation (AR), using...
The personalized external aortic root support procedure: interesting niche or ready for prime time?
Source : https://heart.bmj.com/content/early/2021/08/26/heartjnl-2021-319790.abstract
Aortic root dilation is nearly universal among patients with Marfan syndrome (MFS) and many patients require aortic root replacement to prevent devastating aortic catastrophe. This has traditionally entailed placement of...
Involvement of Endoplasmic Reticulum Stress-Mediated Activation of C/EBP Homologous Protein in Aortic Regurgitation-Induced Cardiac Remodeling in Mice - Journal of Cardiovascular Translational Research
Source : https://link.springer.com/article/10.1007/s12265-021-10162-4
Aortic regurgitation (AR) is a volume overload disease causing eccentric left ventricular (LV) hypertrophy and eventually heart failure. There is currently no approved drug to treat patients with AR. Endoplasmic...
The myosin activator omecamtiv mecarbil improves wall stress in a rat model of chronic aortic regurgitation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34405966/
In patients with chronic aortic regurgitation (AR), excessive preload and afterload increase left ventricle wall stress, leading to left ventricular systolic dysfunction. Thus, the objective of the present study was...