4yr
Evaluating the effect of multivalvular disease on mortality after transcatheter aortic valve replacement for aortic stenosis: a meta-analysis and systematic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35485390/
doi: 10.2217/fca-2021-0061. Online ahead of print. 1 Department of Medicine, University of Mississippi, Jackson, MS 39216, USA. 2 Department of Medicine, Dow University of Health Sciences, Karachi, 74200, Pakistan. 3 Department of Medicine, Ziauddin Medical University, Karachi, 7500, Pakistan. 4 Medical College, Aga Khan University, Karachi, 74800, Pakistan.
Conclusion: Moderate-to-severe MR or TR, and severe MS, significantly increase mid-term mortality after TAVR.
• Source: Future Cardiology
• Conclusion: “Our findings suggest that accompanying moderate-to-severe mitral regurgitation and tricuspid regurgitation leads to an increase in deaths post-TAVR. Likewise, severe mitral stenosis also increased the risk of deaths after TAVR.”
• Moderate-to-severe MR was related to increased mortality at 30 days (HR: ; P = 0.01) and 1 year (HR: 1.87; P = 0.004). whereas all-grade MS did not affect 30-day or 1-year mortality
• A higher risk of 1-year mortality (HR: 1.67; P = 0.04) was noted in patients with severe MS vs. those with no MS.
• Moderate-to-severe TR exhibited higher odds of all-cause mortality at 1 year (HR: 1.49; P < 0.001) vs. no or mild TR.
• “In the current era, the use of TAVR has increased in patients suffering from uncomfortable and potentially life-threatening symptoms of severe aortic stenosis who are at increased risk for undergoing a surgical procedure to replace their valves,” wrote the authors.