The effect of empagliflozin on growth differentiation factor 15 in patients with heart failure: a randomized controlled trial (Empire HF Biomarker) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35219331/
Randomized Controlled Trial doi: 10.1186/s12933-022-01463-2. 1 Department of Cardiology, Research Unit of Cardiology, Odense University Hospital, Odense, Denmark. [email protected]. 2 Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. [email protected]....
Conclusion: Empagliflozin increased plasma levels of GDF-15 in patients with HFrEF, with no concomitant increase in hsTNT nor hsCRP.
The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35228754/
The sodium-glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular death or heart failure hospitalization in patients with chronic heart failure, but whether empagliflozin also improves clinical outcomes when...
Conclusion: "The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial".
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Age-related sex differences in the outcomes of patients with hypertrophic cardiomyopathy
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0264580
Background We aimed to clarify the sex differences in various cardiovascular and non-cardiovascular outcomes, and to investigate whether sex differences in outcomes are affected by age in hypertrophic cardiomyopathy (HCM)....
Conclusions: Women with HCM have worse cardiovascular prognosis than men, driven by higher cardiovascular mortality and HF events. The negative impact of female sex on cardiac function and cardiovascular outcome became prominent at age ≥60 years, suggesting age-related sex differences in the prognosis of HCM.
Conclusions: Women with HCM...
Clinical implications of left atrial reverse remodelling after cardiac resynchronization therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35213709/
doi: 10.1093/ehjci/jeac042. Online ahead of print. 1 Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands. 2 Department of Cardiology, Jessa Hospital, 3500 Hasselt, Belgium....
Conclusions: Patients with complete reverse remodelling have a lower mortality risk than those showing incomplete or no significant reverse remodelling. The use of integrated LA and LV deformation imaging may improve risk-stratification of CRT recipients.
SGLT-2 Inhibitor Use in Heart Failure: A Review for Nurses - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35212658/
1 Clinical Pharmacy Department, Methodist University Hospital, Memphis, Tennessee (Drs March, Lukas, and Cave); University of Tennessee Health Science Center, College of Pharmacy, Memphis (Drs March, Lukas, and Cave); and...
Relevance: The purpose of this review is to summarize available literature focusing on the use of the SGLT-2 inhibitors as adjunctive therapy in heart failure, as well as evaluate mechanisms for heart failure benefit, adverse effects, and practical considerations for using these agents in the clinical setting.