3mo
2mo
Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40146800/
Cardiac fibrosis, a hallmark of heart failure and various cardiomyopathies, represents a complex pathological process that has long challenged therapeutic intervention. High-throughput omics technologies have begun revolutionizing our understanding of...
Multi-omics technologies unravel genetic, epigenetic, transcriptomic, proteomic, and metabolic mechanisms of cardiac fibrosis, revealing fibroblast heterogeneity, biomarkers, and therapeutic targets, driving precision medicine and personalized strategies for heart failure and cardiomyopathies.
2mo
Heart failure, inflammation and exercise - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40520009/
Heart failure (HF) is a condition characterized by high morbidity, mortality, and a substantial healthcare burden, in which inflammation plays a pivotal role. This review provides a comprehensive overview of...
This review highlights inflammation’s central role in heart failure progression, discussing immune alterations, biomarkers, and signaling pathways, while emphasizing exercise’s therapeutic potential through anti-inflammatory modulation and personalized intervention strategies.
3mo
State of precision medicine for heart failure with preserved ejection fraction in a new therapeutic age - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39844745/
Heart failure with preserved ejection fraction (HFpEF) is defined by heart failure (HF) with a left ventricular ejection fraction (LVEF) of at least 50%. HFpEF has a complex and heterogeneous...
HFpEF is a complex, heterogeneous condition challenging to diagnose. Algorithms (H2FPEF, HFA-PEFF), phenotype clustering, and SGLT2 inhibitors aid management, while future research explores precision diagnostics and novel therapies.
3mo
Chronic Heart Failure and Coronary Artery Disease: Pharmacological Treatment and Cardiac Rehabilitation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40005328/
Coronary artery disease is the leading cause of acute and chronic heart failure. Patients with heart failure and ischemic heart disease need a tailored assessment to define the appropriate treatment,...
Coronary artery disease drives heart failure. Comprehensive assessment and multidisciplinary management, including pharmacological therapy and cardiac rehabilitation, improve survival, reduce hospitalizations, and support tailored, guideline-directed care for fragile patients.