Emerging regulatory mechanisms in cardiovascular disease: Ferroptosis
Source : https://pubmed.ncbi.nlm.nih.gov/38518600/
Ferroptosis, distinct from apoptosis, necrosis, autophagy, and other types of cell death, is a novel iron-dependent regulated cell death characterized by the accumulation of lipid peroxides and redox imbalance with...
Ferroptosis, characterized by iron-dependent lipid peroxidation and redox imbalance, plays a crucial role in various cardiovascular diseases. Understanding its mechanisms and modulation could lead to novel prevention and treatment strategies, including the potential use of traditional Chinese medicines.
Colchicine's Role in Cardiovascular Disease Management
Source : https://pubmed.ncbi.nlm.nih.gov/38511324/
Colchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in high doses for the...
Colchicine, originally used for gout, now plays a crucial role in cardiovascular inflammation management, reducing recurrent pericarditis and major adverse cardiovascular events. Its FDA approval marks a milestone, but careful monitoring and research into broader applications are crucial.
SnoRNAs in cardiovascular development, function, and disease
Source : https://pubmed.ncbi.nlm.nih.gov/38523014/
Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as...
snoRNAs are crucial regulators in cardiovascular biology with significant diagnostic and therapeutic potential. Further research is needed to decipher their mechanisms and improve applications in cardiovascular diseases.
Hypothyroidism and metabolic cardiovascular disease
Source : https://pubmed.ncbi.nlm.nih.gov/38887272/
Cardiovascular disease (CVD) remains the leading cause of death worldwide, representing a major health issue of social and economic relevance. Both hyperthyroidism and hypothyroidism are very common in the adult...
Thyroid dysfunction negatively impacts cardiovascular health. L-T4 therapy's benefits are evident for OH and younger SCH patients, but further studies are needed for those over 65 to reduce CVD incidence and mortality.
The Role of Sleep in Cardiovascular Disease
Source : https://pubmed.ncbi.nlm.nih.gov/38795275/
Recent guidelines recommend screening for obstructive sleep apnea in patients with atrial fibrillation. New data continues to demonstrate the importance of sleep quality and duration for CV health. There is...
Sleep is increasingly recognized as an important component of CV health. There is a complex bidirectional relationship between sleep and CVD. Perturbations to normal sleep as well as primary sleep disorders have systemic effects, including changes in autonomic tone and inflammation, which contribute to the development of a wide range of CV...