Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes
OBJECTIVE. To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D).RESEARCH DESIGN AND METHODS.
Researchers identified 3 novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648), rs11444867 (near HS3ST1), and rs335407 (near TFB1M/NOX3).
Participants with untreated and new-onset hypertension had increased risk of newly self-reported fibroids, whereas those taking antihypertensive treatment had lower risk.
Characteristics of High-Performing Hospitals in Cardiogenic Shock Following Acute Myocardial Infarction
Source : https://pubmed.ncbi.nlm.nih.gov/38583700/
Cardiogenic shock after acute myocardial infarction (AMI-CS) carries significant mortality despite advances in revascularization and mechanical circulatory support. We sought to identify the process-based and structural characteristics of centers with...
Centers with lower risk-adjusted in-hospital mortality rates performed more revascularization and demonstrated better adherence to associated process measures.
Cystatin C Is a Predictor for Long-Term All-Cause and Cardiovascular Mortality in US Adults With Metabolic Syndrome
Source : https://pubmed.ncbi.nlm.nih.gov/38597157/
MetS patients with elevated CysC levels have a higher risk of all-cause, CVD, and cancer death. CysC may predict MetS all-cause and CVD mortality.
Cystatin C demonstrated the higher predictive efficacy across mortality outcomes, followed by eGFR, outperforming urea nitrogen, creatinine, uric acid, and C-reactive protein.
Clonal Hematopoiesis: the Emergent CVD Risk Factor
Source : https://pubmed.ncbi.nlm.nih.gov/38536898/
Clonal Hematopoiesis: The Emergent CVD Risk Factor
Although a patient with non–TET2-driven clonal hematopoiesis did not observe a benefit from treatment, it will be important to more thoroughly characterize the distinct pathogenesis of other driver genes in CVD to exploit this understanding.