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Proprotein convertase subtilisin/kexin type 9 inhibitor non responses in an adult with a history of coronary revascularization: A case report

Proprotein convertase subtilisin/kexin type 9 inhibitor non responses in an adult with a history of coronary revascularization: A case report

Source : https://www.wjgnet.com/2307-8960/full/v10/i19/6728.htm

Proprotein convertase subtilisin/kexin type 9 inhibitor non responses in an adult with a history of coronary revascularization: A case report Liu Yang, Yan-Yan Xiao, Liang Shao, Chang-Sheng Ouyang, Yao Hu,...


Conclusion: Our outcome demonstrates that LDLR-W483X represents a partial loss-of-function LDLR and may contribute to PCSK9i ineffective. In the meanwhile, additional measures are therefore required (particularly with gene sequencing or change the treatment plan) must be initiated as early as possible. Genetic testing for clinically challenging...

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Non-Statin LDL-C Treatment Options

Up to 30% of patients prescribed treatment to lower LDL-C are intolerant of statins and discontinue taking them1,2. Additionally, a large segment of the LDL-C population is not at treatment goal3. These patients require additional non-statin therapy or an entirely non-statin alternative.



When considering a non-statin therapy for your patients, whether as add-on or replacement, how important are each of the following traits: oral vs. injectable product, effect on CRP, low risk of new incident diabetes? European and US guidelines differ as do AHA/ACC and AACE/ACE; which guidelines do you follow and why?




  • 3yr
    I also follow AHA guidelines unless there is a compelling reason not to. Statin therapy is still considered first line along with lifestyle modification and non statin orals can be Show More
  • 3yr
    What about very high calcium scoring test? Ideas

Show More Comments

  • Saved
Non-Statin LDL-C Treatment Options

Up to 30% of patients prescribed treatment to lower LDL-C are intolerant of statins and discontinue taking them1,2. Additionally, a large segment of the LDL-C population is not at treatment goal3. These patients require additional non-statin therapy or an entirely non-statin alternative.

When considering a non-statin therapy for your patients, whether as add-on or replacement, how important are each of the following traits: oral vs. injectable product, effect on CRP, low risk of new incident diabetes? European and US guidelines differ as do AHA/ACC and AACE/ACE; which guidelines do you follow and why?

  • 3yr
    I also follow AHA guidelines unless there is a compelling reason not to. Statin therapy is still considered first line along with lifestyle modification and non statin orals can be Show More
  • 3yr
    What about very high calcium scoring test? Ideas

Show More Comments

  • Saved
Non-Statin LDL-C Treatment Options

Up to 30% of patients prescribed treatment to lower LDL-C are intolerant of statins and discontinue taking them1,2. Additionally, a large segment of the LDL-C population is not at treatment goal3. These patients require additional non-statin therapy or an entirely non-statin alternative.



When considering a non-statin therapy for your patients, whether as add-on or replacement, how important are each of the following traits: oral vs. injectable product, effect on CRP, low risk of new incident diabetes? European and US guidelines differ as do AHA/ACC and AACE/ACE; which guidelines do you follow and why?




  • 3yr
    I also follow AHA guidelines unless there is a compelling reason not to. Statin therapy is still considered first line along with lifestyle modification and non statin orals can be Show More
  • 3yr
    What about very high calcium scoring test? Ideas

Show More Comments

  • Saved
Non-Statin LDL-C Treatment Options

Up to 30% of patients prescribed treatment to lower LDL-C are intolerant of statins and discontinue taking them1,2. Additionally, a large segment of the LDL-C population is not at treatment goal3. These patients require additional non-statin therapy or an entirely non-statin alternative.



When considering a non-statin therapy for your patients, whether as add-on or replacement, how important are each of the following traits: oral vs. injectable product, effect on CRP, low risk of new incident diabetes? European and US guidelines differ as do AHA/ACC and AACE/ACE; which guidelines do you follow and why?




  • 3yr
    I also follow AHA guidelines unless there is a compelling reason not to. Statin therapy is still considered first line along with lifestyle modification and non statin orals can be Show More
  • 3yr
    What about very high calcium scoring test? Ideas

Show More Comments