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3yr
Non-Statin LDL-C Treatment Options

Up to 30% of patients prescribed treatment to lower LDL-C are intolerant of statins and discontinue taking them1,2. Additionally, a large segment of the LDL-C population is not at treatment goal3. These patients require additional non-statin therapy or an entirely non-statin alternative.



When considering a non-statin therapy for your patients, whether as add-on or replacement, how important are each of the following traits: oral vs. injectable product, effect on CRP, low risk of new incident diabetes? European and US guidelines differ as do AHA/ACC and AACE/ACE; which guidelines do you follow and why?




  • 3yr
    I also follow AHA guidelines unless there is a compelling reason not to. Statin therapy is still considered first line along with lifestyle modification and non statin orals can be Show More
  • 3yr
    What about very high calcium scoring test? Ideas

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Evaluation of the Effectiveness of Individually Tailored Lifestyle Intervention in Patients With Familial Hypercholesterolemia - PubMed

Evaluation of the Effectiveness of Individually Tailored Lifestyle Intervention in Patients With Familial Hypercholesterolemia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35952313/

Objectives: The aim of this study was to evaluate the effect of a theoretically-based individually tailored lifestyle intervention on healthy lifestyle changes and improvement in disease management in patients with...


Conclusions: Our results showed that an individually tailored lifestyle intervention was effective in facilitating healthy lifestyle changes and improvement in treatment adherence and in decreasing cardiovascular risk factors including cholesterol levels in patients with FH.

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3yr
Risk assessment indicators and brachial-ankle pulse wave velocity to predict atherosclerotic cardiovascular disease - PubMed

Risk assessment indicators and brachial-ankle pulse wave velocity to predict atherosclerotic cardiovascular disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35960056/

Brachial-ankle pulse wave velocity (baPWV) is used for predicting the severity of vascular damage and prognosis of atherosclerotic cardiovascular disease (ASCVD) in people with hypertension and diabetes mellitus. This correlation...


Relevance: This correlation study aimed to compare the baPWV with other risk indicators for identification of subclinical vascular disease for primary prevention and to determine the clinical utility of baPWV-guided therapy in improving prognosis in high-risk subjects.

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3yr
Assessing the external validity of the SAFEHEART risk prediction model in patients with familial hypercholesterolaemia in an English routine care cohort

Assessing the external validity of the SAFEHEART risk prediction model in patients with familial hypercholesterolaemia in an English routine care cohort

Source : https://www.atherosclerosis-journal.com/article/S0021-9150(22)01352-1/fulltext

There are no well validated cardiovascular risk prediction tools for people with familial hypercholesterolaemia. * The SAFEHEART model was recently developed in a bespoke genetically defined cohort. * Outcomes departed...



Conclusion/Relevance: The original SAFEHEART model has limited generalisability to the routinely identifiable English primary care FH population. With recalibration it appears to have moderate utility at 10–30% predicted risk. It may have greater validity in more bespoke genetically defined FH populations.


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3yr
The role of inflammation and the possibilities of inflammation reduction to prevent cardiovascular events - PubMed

The role of inflammation and the possibilities of inflammation reduction to prevent cardiovascular events - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35919577/

Chronic systemic inflammation is a risk factor for cardiovascular (CV) disease (CVD). Whether this relationship extends to subclinical inflammation, quantified by values of circulating markers associated with inflammation in the...



Relevance: Chronic systemic inflammation is a risk factor for cardiovascular (CV) disease (CVD). Whether this relationship extends to subclinical inflammation, quantified by values of circulating markers associated with inflammation in the high range of the normal interval, remains debatable. This narrative review evaluates evidence exploring...