HIF-mediated hierarchical hypoxic adaptation, a novel paradigm in heart failure pathogenesis: is there a role for targeted therapies? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41919236/
Heart failure (HF) is a terminal cardiovascular syndrome related to systemic hypoxia. Hypoxia is considered a fundamental pathophysiological process, and the resulting tissue response depends on the severity and duration...
Review proposes HIF-driven heart failure follows hierarchical hypoxic adaptation: acute activation may protect myocardium, chronic activation promotes maladaptive remodeling. HIF-targeted therapies are promising, but efficacy, timing, and context remain uncertain.
Measuring patient adherence in secondary prevention of atherosclerotic cardiovascular disease: a scoping review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41887635/
Medication adherence was the most frequently assessed domain in secondary prevention of ASCVD, with unspecified PROMs being the most applied measurement approach. Lack of a gold standard combined with inconsistent...
Scoping review maps adherence measures in ASCVD secondary prevention across 108 studies; medication (62%) and smoking cessation (60%) most assessed, primarily via unspecified PROMs, revealing no gold standard.
Electrocardiographic Artifact Caused by Deep Brain Stimulation Mimicking Atrial Flutter in Patient With Contralateral Pacemaker - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41848453/
Recognition of DBS-induced ECG artifact is important to ensure appropriate diagnosis and avoid unnecessary interventions. DBS and CIEDs systems can safely coexist without electrical interference when appropriate safety precautions are...
Deep brain stimulation can cause ECG artifacts mimicking atrial flutter; device interrogation confirms true rhythm, preventing misdiagnosis. DBS and pacemakers can safely coexist without interference with proper evaluation.
Hemodialysis versus peritoneal dialysis and diastolic blood pressure variability: volume-dependent cardiovascular risks in maintenance dialysis patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41820019/
This retrospective study analyzed hemodialysis (HD) and peritoneal dialysis (PD) impacts on diastolic blood pressure variability (DBPV) in Stage 5 chronic kidney disease (CKD-G5D) patients, explored volume-related indicator associations with...
Retrospective study shows hemodialysis patients have higher diastolic blood pressure variability than peritoneal dialysis patients; variability strongly correlates with interdialytic weight gain and predicts cardiovascular events, highlighting importance of volume management.
Differential Diagnosis between Sintilimab-related Autoimmune Myocarditis and Acute Myocardial Infarction - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41776397/
The manifestations of sintilimab-related autoimmune myocarditis are not specific. The medication history and concomitant symptoms are of warning value. Coronary angiography or coronary computed coronary tomography angiography can be helpful...
Review of 23 cases shows sintilimab-related autoimmune myocarditis often presents with nonspecific symptoms and elevated cardiac biomarkers; medication history, coronary imaging, cardiac MRI, and biopsy help differentiate it from acute myocardial infarction.