Evaluating the effect of multivalvular disease on mortality after transcatheter aortic valve replacement for aortic stenosis: a meta-analysis and systematic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35485390/
doi: 10.2217/fca-2021-0061. Online ahead of print. 1 Department of Medicine, University of Mississippi, Jackson, MS 39216, USA. 2 Department of Medicine, Dow University of Health Sciences, Karachi, 74200, Pakistan. 3...
Conclusion: Moderate-to-severe MR or TR, and severe MS, significantly increase mid-term mortality after TAVR.
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Aortic Stenosis Connect4yrKey Points • Source: Future Cardiology • Conclusion: “Our findings suggest that accompanying moderate-to-severe mitral regurgitation and tricuspid regurgitation leads to an increase in deaths post-TAVR. Likewise, severe mitral stenosis also increased the risk Show More
A little leak goes a long way! 5-Year-outcome after transcatheter aortic valve implantation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35476286/
Mild paravalvular leak after TAVR is associated with increased 5-year mortality. Current noninvasive and invasive prediction models for mortality may only hold for short term outcomes. Other imaging modalities aside...
Conclusion/Relevance: Mild paravalvular leak after TAVR is associated with increased 5-year mortality. Current noninvasive and invasive prediction models for mortality may only hold for short term outcomes. Other imaging modalities aside from transthoracic echocardiography should be strongly considered when assessing paravalvular leak,...
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Aortic Stenosis Connect4yrWhat clinical insights can you provide regarding mild paravalvular leak post-TAVR? What is your clinical approach in such cases? How do you advise patients regarding this complication?
Enduring ROS emission causes aberrant protein S-glutathionylation transitioning human aortic valve cells from a sclerotic to a stenotic phenotype - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35459416/
doi: 10.1089/ars.2021.0133. Online ahead of print. 1 Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, 18607, Unit for the Study of Aortic, Valvular, and Coronary Pathologies, Milano,...
Conclusion: Our data suggest that, in the human aortic valve, unremitted ROS emission along with a P-SSG build-up occurs and accounts, at least in part, for the morphological/functional changes leading to calcific aortic valve stenosis.
Severe Aortic Valve Stenosis and Pulmonary Hypertension: A Systematic Review of Non-Invasive Ways of Risk Stratification, Especially in Patients Undergoing Transcatheter Aortic Valve Replacement - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35455719/
Patients with severe aortic valve stenosis and concomitant pulmonary hypertension show a significantly reduced survival prognosis. Right heart catheterization as a preoperative diagnostic tool to determine pulmonary hypertension has been...
Conclusion/Relevance: The aim of the present systematic review was to highlight noninvasive possibilities for the detection of pulmonary hypertension in patients with severe aortic valve stenosis, with a special focus on cardiovascular biomarkers. A total of 525 publications regarding echocardiography, cardiovascular imaging and biomarkers...
Strategies for Facilitating Totally Percutaneous Transfemoral TAVR Procedures - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35456197/
Transcatheter aortic valve replacement (TAVR) has transformed the treatment of aortic stenosis and should ideally be performed as a totally percutaneous procedure via the transfemoral (TF) approach. Peripheral vascular disease...
Conclusion/Relevance: We review strategies aimed to facilitate TF valve delivery in patients with hostile vascular anatomy and achieve percutaneous management of vascular complications.