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73 y.o. with low-flow, low-gradient severe aortic stenosis

A 73-year-old man with history of hypertension presents with New York Heart Association Class III symptoms of exertional dyspnea and fatigue. Auscultation demonstrates a crescendo-decrescendo, midsystolic ejection murmur. Results of a previous echo showed no valvular heart disease.

Echo readings were as follows:

  • aortic valve area < 1 cm2
  • jet velocity = 3.5 m/s
  • mean transvalvular gradient = 33mm Hg
  • LVEF < 50%

How do you determine whether the patient has severe or pseudo-severe aortic stenosis?

How does the team proceed if there is discordance between the hemodynamics and the aortic valve area?

  • 3yr
    Agree with above posts, AVA indicates the severity. A DSE
    Will confirm this as will a cardiac cath. Moreover if there are symptoms of angina and syncope , the above will be a formality before defining tavi vs surgery .
  • 3yr
    there is enough evidence of significant aortic stenosis with symptoms and data provided at this time. Therefore I would recommend cardiac cath and coronary angiography which he would require
    anyway before Aortic Stenosis is treated by transcatheter approach or by surgical valve replacement.
  • 3yr
    This patient has symptomatic severe low flow low gradient AS. The valve area is less than 1cm2. A dimensionless index less than would further support severe AS. Exam features (not all described in this case) of a diminished or absent A2, a murmur that peaks later in systole, or a delayed carotid upstroke relative to A2 can support severe AS. A dobutamine stress echo can differentiate pseudo AS from true severe AS.
  • 3yr
    DSE and CT of the valve should aid therapy in this patient.
  • 3yr
    Dimensionless index, DSE, and CT for AV Ca score can all be of utility - although with #s provided in clinical scenario severe AS most likely.
  • 3yr
    It is low flow low gradient AS, so DSE is likely the study of choice, although I will say that a jet in the setting of low EF (I don't know how low), is probably not all that low and given his symptoms, I expect that this is severe AS that will likely benefit from treatment.
  • 3yr
    DSE is the test of choice as well
  • 3yr
    Hi. This is most likely severe. Guidelines would suggest a DSE to show gradient/AVA are consistent with severe AS, then intervention as warranted. Would suggest LVEF be given next time as it would never be written as simply less than 50.
  • 3yr
    Probably has severe AS, definitely moderate already. I’d check the DVI and if < , it’s likely severe. Additionally I’d check the stroke volume index (SVi) and if <35cc/m2, it’s likely LFLG. ANOTHET tool I use is the AT/ET ratio. If <.34, it suggests severe AS even in presence of LFLG state.

    DSE to increase stroke volume is reasonable alternative as is checking the calcium score.
  • 3yr
    Most likely it’s severe As but DSE is quite helpful. Other option would be to look at calcification by CT. Though DSE would be more definitive
  • 3yr
    DSE is the test of choice. But DI would go a long way towards pointing you int he correct direction. He looks severe by the data/PE you provide already. And with European data, that would support fixing the pt even if it was P-AS! It hasn't quite made it to US guidelines yet.
  • 3yr
    Would do DSE after getting better assessment of LVEF then just < 50. Would then do cardiac cath to assess coronary arteries and get another assessment of AV gradient
  • 3yr
    one could do a DSE but I dont think it is necessary. By current measurements alone he has at least moderately severe aortic stenosis and since he is symptomatic we have enough to suggest intervention.
  • 3yr
    I agree that it probably is severe, since he is symptomatic. But he could have moderate aortic rather than severe in some case, and other sources for dyspnea. For example if the LVOT diameter was underestimate, or if rhythm was atrial fibrillation with great beat to beat variability in jet velocity, the severity can be overestimated. Thus in borderline cases, a dobutamine stress echo or CT scan for aortic valve calcium measurement can help. If severe CAD is found on cath, then usually proceed with surgical revascularization and surgical AVR even if moderate aortic valve stenosis, since he is symptomatic.
  • 3yr
    DSE would be my first test to distinguish AS from pseudo AS in this patient , his current profile Of trans aortic flow would likely generate a further increase in gradient and velocity though I am curious how much less than 50 percent the ejection fraction actually is. the EF is not stated in the case.
    Likely difference in expected findings of AS severity if his EF is 35 percent versus 48 percent following dobutamine stress echo.
  • 3yr
    I recommend calculating the TVI ratio (dimensionless ratio). A TVI ratio below favors severe aortic valve stenosis. Then calculate the stroke volume index to determine if classic vs paradoxal low flow low gradient severe aortic valve stenosis.
    If borderline TVI ratio, then a dobutamine stess echo can be done to induce a rise in stroke volume and aortic valve gradient. But now I often obtain a chest CT focused on measuring the aortic valve calcification and if score is above 1000, then aortic valve stenosis is likely severe enough for a TAVR consult.
    Of note, most of these patients with low LVEF have other comorbidities, such as ischemic heart disease.
  • 3yr
    This appears to be severe AS. The LV function is reduced with AVA of less then 1 cm2. Don't think any additional testing is needed as the patient also has symptoms. If there is still dispute could consider cath which patient needs anyway and/or DSE as was mentioned.
  • 3yr
    This is a low flow low gradient AS, would need to consider transthyretin cardiac amyloidosis, PYP scan should be done to initially. If PYP scan is negative would recommend DSE.
  • 3yr
    You could do a DSE to see if mean gradient increases. Aortic valve CT May also be helpful. Physical exam point to severe AS so honestly you may have enough information to make the call.

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