When Pacing Fails After Generator Replacement: A Stepwise Diagnostic Approach to a Reversible Lead-Header Interface Problem - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42200841/
Background and Clinical Significance : Early loss of pacing capture after pacemaker generator replacement is an uncommon but potentially life-threatening event, especially in pacemaker-dependent patients. In this setting, device malfunction...
Case highlights a reversible lead-header interface problem causing early loss of pacemaker capture after generator replacement, where a stepwise diagnostic approach using pacing configuration analysis, imaging, and intraoperative testing avoided unnecessary lead revision or extraction.
Ten-year clinical course of familial lecithin-cholesterol acyltransferase deficiency caused by Cys74Tyr mutation leading to dialysis and multiple systemic complications: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42159827/
Familial lecithin-cholesterol acyltransferase deficiency (FLD) is a rare hereditary disorder. In FLD, a clinical triad of corneal opacity, anemia, and proteinuria typically precedes progressive renal dysfunction. Although early renal involvement...
Case report describes a decade-long progression of familial LCAT deficiency with Cys74Tyr mutation, leading to dialysis-dependent renal failure, cardiovascular and neurovascular complications, and anemia improvement following hemodialysis initiation.
Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40434761/
ClinicalTrials.gov Identifier: NCT05103332.
KARDIA-2 showed that add-on zilebesiran, an RNA interference therapy targeting angiotensinogen, significantly lowered ambulatory systolic blood pressure for 3 months in uncontrolled hypertension, with mostly mild hyperkalemia, hypotension, and kidney-related adverse events.
Delayed Diagnoses of Cardiac Amyloidosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40645707/
Cardiac sarcoidosis (CS) can be challenging to accurately diagnose and relies on a complex diagnostic framework because of the limited sensitivity of endomyocardial biopsy. Frequently, the diagnosis of CS depends...
This report describes misdiagnosed cardiac sarcoidosis later confirmed as wild-type transthyretin cardiac amyloidosis, underscoring limitations of imaging-based diagnosis and the critical role of endomyocardial biopsy for accurate classification.
Evaluative performance of TyG-ABSI versus traditional indices in relation to cardiovascular disease and mortality: evidence from the U.S. NHANES - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40841630/
Our study highlights the value of TyG-ABSI in assessing cardiovascular disease and mortality risk in populations with MetS, providing new evidence for medical practice and public health interventions.
TyG-ABSI, combining insulin resistance and central obesity, better predicts CVD and mortality than traditional TyG indices in MetS. NHANES data show strong, dose-dependent associations and superior predictive performance across analyses.