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The Potential Role of Retinol-Binding Protein 4 in Heart Failure: A Review - PubMed

The Potential Role of Retinol-Binding Protein 4 in Heart Failure: A Review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41089778/

Heart failure (HF) is a heterogeneous clinical syndrome, the prevalence of which is increasing among younger adults, promoting global concern due to its significant morbidity and mortality. Therefore, predicting the...

This review explores retinol-binding protein 4 (RBP4) as a biomarker and pathogenic mediator in heart failure, linking it to insulin resistance, inflammation, oxidative stress, and myocardial injury, while emphasizing research gaps.

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Use of 2 Ventricular Assist Devices as a Total Artificial Heart for Heart Failure - PubMed

Use of 2 Ventricular Assist Devices as a Total Artificial Heart for Heart Failure - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41055626/

HM6 implantation can be used to manage severe biventricular heart failure in patients who are not candidates for heart transplant.

A young patient with severe biventricular heart failure and ineligible for transplant underwent successful implantation of two HeartMate 3 devices (HeartMate 6 configuration) as a total artificial heart alternative.

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Did you know? A Bulgarian study found 79 of 142 ADR reports on cardiovascular drugs were serious. Sartans like valsartan were linked to melanoma and other cancers within 2–5 years. Statins and ACE inhibitors also showed alarming reactions like MI, heart failure, and arrhythmia—calling for more vigilant prescribing and follow-up.

Could awareness of serious ADRs like cancer from sartans influence your approach to monitoring patients and selecting cardiovascular treatments?

NCCN Guidelines

Could awareness of serious ADRs like cancer from sartans influence your approach to monitoring patients and selecting cardiovascular treatments?

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Genetic mutations were found in 71% of arrhythmia patients with cardiac devices. Variants in TMEM43 and titin (TTN) are linked to poor CRT outcomes. Personalised selection, such as using transvenous ICDs for ACM, improves prognosis and care.

Leverage genetics to tailor cardiac care

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Worsening versus advanced heart failure: Management and challenges - PubMed

Worsening versus advanced heart failure: Management and challenges - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41045229/

Heart failure (HF) is a progressive condition marked by recurrent episodes of symptom exacerbation, leading to worsening cardiac function, increased hospitalization and mortality risk. Worsening HF (WHF) and advanced HF...

 

This review differentiates worsening from advanced heart failure, emphasizing diagnostic criteria, clinical progression, and treatment strategies. It advocates early recognition to optimize therapy, prevent disease escalation, and improve outcomes in advanced stages.