Cardiac magnetic resonance-derived tissue tracking strain in patients with hypertrophic cardiomyopathy
Source : https://qims.amegroups.com/article/view/105485/html
We read with great interest the study by Chen et al. ( 1). Recent developments in tissue tracking cardiac magnetic resonance (CMR) have enabled the quantitative assessment of myocardial strain...
Conclusion: Due to these and many other problems, echo is still the method of choice for strain evaluation in clinical practice rather than CMR.
Efficacy and safety of pemafibrate in patients with chronic kidney disease: A retrospective study
brates, such as bezafibrate (Beza-F) and fenofibrate (Feno-F), are the mainstay for hypertriglyceridemia treatment, they may be associated with a risk of increased serum creatinine level and renal dysfunction. Pemafibrate...
Conclusion: We suggest that Pema may be an effective and safe treatment for hypertriglyceridemia in CKD patients.
Bempedoic Acid
Source : https://www.ncbi.nlm.nih.gov/books/NBK563398
No relevant published information exists on the use of bempedoic acid during breastfeeding. Bempedoic acid and its metabolites are 99% plasma protein bound, so amounts in milk are likely very...
Summary: No relevant published information exists on the use of bempedoic acid during breastfeeding. Bempedoic acid and its metabolites are 99% plasma protein bound, so amounts in milk are likely very low. However, because of a concern with disruption of infant lipid metabolism, bempedoic acid is best avoided during breastfeeding. An alternate...
Gene editing for dyslipidemias: New tools to "cut" lipids
Source : https://www.atherosclerosis-journal.com/article/S0021-9150(23)00011-4/fulltext
Effective lipid lowering therapies are essential for the prevention of atherosclerosis and cardiovascular disease. Available treatments have evolved in both their efficacy and their frequency of administration, and currently include...
Conclusions/Relevance: This review provides a general overview of this promising technology and an update on the progress made towards the development of treatments of dyslipidemia. The recently started phase 1b gene editing clinical trial targeting PCSK9 in patients with heterozygous familial hypercholesterolemia and cardiovascular disease...
Cardiovascular Manifestations in Rheumatoid Arthritis : Cardiology in Review
A. Cardiovascular manifestations of RA include accelerated atherosclerosis, heart failure, pericarditis, myocarditis, endocarditis, rheumatoid nodules, and amyloidosis. Inflammation is an important mediator of endothelial dysfunction and is a key driver...
Relevance: Cardiovascular involvement is a leading cause of mortality in RA. Cardiovascular manifestations of RA include accelerated atherosclerosis, heart failure, pericarditis, myocarditis, endocarditis, rheumatoid nodules, and amyloidosis. Inflammation is an important mediator of endothelial dysfunction and is a key driver of cardiovascular...